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Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial.
Circulation. 2011 Dec 20; 124(25):2829-38.Circ

Abstract

BACKGROUND

We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes).

METHODS AND RESULTS

DiOGenes is a pan-European controlled dietary intervention study in 932 overweight adults who first lost body weight on an 8-week low-calorie diet and were then randomized to 1 of 5 ad libitum diets for 26 weeks. The diets were either high or low protein or high or low glycemic index in 4 combinations or control. Weight loss (-11.23 kg; 95% confidence interval, -11.54 to -10.92; P<0.001) reduced high-sensitivity C-reactive protein (-1.15 mg/L; 95% confidence interval, -1.30 to -0.41; P<0.001), low- and high-density lipoprotein cholesterol, triglycerides, and blood pressure. During the 26-week weight maintenance period in the intention-to-treat analysis, the further decrease of high-sensitivity C-reactive protein blood levels was -0.46 mg/L greater (95% confidence interval, -0.79 to -0.13) in the groups assigned to low-glycemic-index diets than in those on high-glycemic-index diets (P<0.001). Groups on low-protein diets achieved a -0.25 mg/L greater reduction in high-sensitivity C-reactive protein (95% confidence interval, -0.59 to -0.17) than those on high-protein diets (P<0.001), whereas lipid profiles and blood pressure were not differently affected.

CONCLUSIONS

This large-scale intervention study clearly separates weight loss from dietary composition-related effects. Low-glycemic-index carbohydrates and, to a lesser extent, low-protein intake may specifically reduce low-grade inflammation and associated comorbidities in overweight/obese adults.

CLINICAL TRIAL REGISTRATION

http://www.clinicaltrials.gov. Unique identifier: NCT00390637.

Authors+Show Affiliations

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22104550

Citation

Gögebakan, Ozlem, et al. "Effects of Weight Loss and Long-term Weight Maintenance With Diets Varying in Protein and Glycemic Index On Cardiovascular Risk Factors: the Diet, Obesity, and Genes (DiOGenes) Study: a Randomized, Controlled Trial." Circulation, vol. 124, no. 25, 2011, pp. 2829-38.
Gögebakan O, Kohl A, Osterhoff MA, et al. Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial. Circulation. 2011;124(25):2829-38.
Gögebakan, O., Kohl, A., Osterhoff, M. A., van Baak, M. A., Jebb, S. A., Papadaki, A., Martinez, J. A., Handjieva-Darlenska, T., Hlavaty, P., Weickert, M. O., Holst, C., Saris, W. H., Astrup, A., & Pfeiffer, A. F. (2011). Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial. Circulation, 124(25), 2829-38. https://doi.org/10.1161/CIRCULATIONAHA.111.033274
Gögebakan O, et al. Effects of Weight Loss and Long-term Weight Maintenance With Diets Varying in Protein and Glycemic Index On Cardiovascular Risk Factors: the Diet, Obesity, and Genes (DiOGenes) Study: a Randomized, Controlled Trial. Circulation. 2011 Dec 20;124(25):2829-38. PubMed PMID: 22104550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial. AU - Gögebakan,Ozlem, AU - Kohl,Angela, AU - Osterhoff,Martin A, AU - van Baak,Marleen A, AU - Jebb,Susan A, AU - Papadaki,Angeliki, AU - Martinez,J Alfredo, AU - Handjieva-Darlenska,Teodora, AU - Hlavaty,Petr, AU - Weickert,Martin O, AU - Holst,Claus, AU - Saris,Wim H M, AU - Astrup,Arne, AU - Pfeiffer,Andreas F H, AU - ,, Y1 - 2011/11/21/ PY - 2011/11/23/entrez PY - 2011/11/23/pubmed PY - 2012/2/18/medline SP - 2829 EP - 38 JF - Circulation JO - Circulation VL - 124 IS - 25 N2 - BACKGROUND: We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes). METHODS AND RESULTS: DiOGenes is a pan-European controlled dietary intervention study in 932 overweight adults who first lost body weight on an 8-week low-calorie diet and were then randomized to 1 of 5 ad libitum diets for 26 weeks. The diets were either high or low protein or high or low glycemic index in 4 combinations or control. Weight loss (-11.23 kg; 95% confidence interval, -11.54 to -10.92; P<0.001) reduced high-sensitivity C-reactive protein (-1.15 mg/L; 95% confidence interval, -1.30 to -0.41; P<0.001), low- and high-density lipoprotein cholesterol, triglycerides, and blood pressure. During the 26-week weight maintenance period in the intention-to-treat analysis, the further decrease of high-sensitivity C-reactive protein blood levels was -0.46 mg/L greater (95% confidence interval, -0.79 to -0.13) in the groups assigned to low-glycemic-index diets than in those on high-glycemic-index diets (P<0.001). Groups on low-protein diets achieved a -0.25 mg/L greater reduction in high-sensitivity C-reactive protein (95% confidence interval, -0.59 to -0.17) than those on high-protein diets (P<0.001), whereas lipid profiles and blood pressure were not differently affected. CONCLUSIONS: This large-scale intervention study clearly separates weight loss from dietary composition-related effects. Low-glycemic-index carbohydrates and, to a lesser extent, low-protein intake may specifically reduce low-grade inflammation and associated comorbidities in overweight/obese adults. CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov. Unique identifier: NCT00390637. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/22104550/Effects_of_weight_loss_and_long_term_weight_maintenance_with_diets_varying_in_protein_and_glycemic_index_on_cardiovascular_risk_factors:_the_diet_obesity_and_genes__DiOGenes__study:_a_randomized_controlled_trial_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.111.033274?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -