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Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4).
Ann Oncol 2012; 23(7):1880-8AO

Abstract

BACKGROUND

To evaluate the dose-response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables.

METHODS

We analyzed data from 12 case-control studies within the International Pancreatic Cancer Case-Control Consortium (PanC4), including 6507 pancreatic cases and 12 890 controls. We estimated summary odds ratios (ORs) by pooling study-specific ORs using random-effects models.

RESULTS

Compared with never smokers, the OR was 1.2 (95% confidence interval [CI] 1.0-1.3) for former smokers and 2.2 (95% CI 1.7-2.8) for current cigarette smokers, with a significant increasing trend in risk with increasing number of cigarettes among current smokers (OR=3.4 for ≥35 cigarettes per day, P for trend<0.0001). Risk increased in relation to duration of cigarette smoking up to 40 years of smoking (OR=2.4). No trend in risk was observed for age at starting cigarette smoking, whereas risk decreased with increasing time since cigarette cessation, the OR being 0.98 after 20 years.

CONCLUSIONS

This uniquely large pooled analysis confirms that current cigarette smoking is associated with a twofold increased risk of pancreatic cancer and that the risk increases with the number of cigarettes smoked and duration of smoking. Risk of pancreatic cancer reaches the level of never smokers ∼20 years after quitting.

Authors+Show Affiliations

Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. cristina.bosetti@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22104574

Citation

Bosetti, C, et al. "Cigarette Smoking and Pancreatic Cancer: an Analysis From the International Pancreatic Cancer Case-Control Consortium (Panc4)." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 7, 2012, pp. 1880-8.
Bosetti C, Lucenteforte E, Silverman DT, et al. Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). Ann Oncol. 2012;23(7):1880-8.
Bosetti, C., Lucenteforte, E., Silverman, D. T., Petersen, G., Bracci, P. M., Ji, B. T., ... La Vecchia, C. (2012). Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(7), pp. 1880-8. doi:10.1093/annonc/mdr541.
Bosetti C, et al. Cigarette Smoking and Pancreatic Cancer: an Analysis From the International Pancreatic Cancer Case-Control Consortium (Panc4). Ann Oncol. 2012;23(7):1880-8. PubMed PMID: 22104574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). AU - Bosetti,C, AU - Lucenteforte,E, AU - Silverman,D T, AU - Petersen,G, AU - Bracci,P M, AU - Ji,B T, AU - Negri,E, AU - Li,D, AU - Risch,H A, AU - Olson,S H, AU - Gallinger,S, AU - Miller,A B, AU - Bueno-de-Mesquita,H B, AU - Talamini,R, AU - Polesel,J, AU - Ghadirian,P, AU - Baghurst,P A, AU - Zatonski,W, AU - Fontham,E, AU - Bamlet,W R, AU - Holly,E A, AU - Bertuccio,P, AU - Gao,Y T, AU - Hassan,M, AU - Yu,H, AU - Kurtz,R C, AU - Cotterchio,M, AU - Su,J, AU - Maisonneuve,P, AU - Duell,E J, AU - Boffetta,P, AU - La Vecchia,C, Y1 - 2011/11/21/ PY - 2011/11/23/entrez PY - 2011/11/23/pubmed PY - 2012/10/23/medline SP - 1880 EP - 8 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 7 N2 - BACKGROUND: To evaluate the dose-response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables. METHODS: We analyzed data from 12 case-control studies within the International Pancreatic Cancer Case-Control Consortium (PanC4), including 6507 pancreatic cases and 12 890 controls. We estimated summary odds ratios (ORs) by pooling study-specific ORs using random-effects models. RESULTS: Compared with never smokers, the OR was 1.2 (95% confidence interval [CI] 1.0-1.3) for former smokers and 2.2 (95% CI 1.7-2.8) for current cigarette smokers, with a significant increasing trend in risk with increasing number of cigarettes among current smokers (OR=3.4 for ≥35 cigarettes per day, P for trend<0.0001). Risk increased in relation to duration of cigarette smoking up to 40 years of smoking (OR=2.4). No trend in risk was observed for age at starting cigarette smoking, whereas risk decreased with increasing time since cigarette cessation, the OR being 0.98 after 20 years. CONCLUSIONS: This uniquely large pooled analysis confirms that current cigarette smoking is associated with a twofold increased risk of pancreatic cancer and that the risk increases with the number of cigarettes smoked and duration of smoking. Risk of pancreatic cancer reaches the level of never smokers ∼20 years after quitting. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/22104574/Cigarette_smoking_and_pancreatic_cancer:_an_analysis_from_the_International_Pancreatic_Cancer_Case_Control_Consortium__Panc4__ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr541 DB - PRIME DP - Unbound Medicine ER -