Tags

Type your tag names separated by a space and hit enter

Benzocaine-loaded polymeric nanocapsules: study of the anesthetic activities.
J Pharm Sci 2012; 101(3):1157-65JP

Abstract

This paper describes a comparison of different polymeric nanocapsules (NCs) prepared with the polymers poly(D,L-lactide-co-glycolide), poly(L-lactide) (PLA), and poly(ε-caprolactone) and used as carrier systems for the local anesthetic (LA) benzocaine (BZC). The systems were characterized and their anesthetic activities investigated. The results showed particle size distributions with polydispersity indices below 0.135, average diameters up to 120 nm, zeta potentials up to -30 mV, and entrapment efficiencies around 70%. Formulations of BZC using the polymeric NCs presented slower release profiles, compared with that of free BZC. Slowest release (release constant, k = 0.0016 min(-1)) was obtained using the PLA NC system. Pharmacological evaluation showed that encapsulation of BZC in PLA NCs prolonged its anesthetic action. This new formulation could potentially be used in future applications involving the gradual release of local anesthetics (LAs).

Authors+Show Affiliations

Department of Biochemistry, State University of Campinas, Campinas, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22105694

Citation

De Melo, Nathalie Ferreira Silva, et al. "Benzocaine-loaded Polymeric Nanocapsules: Study of the Anesthetic Activities." Journal of Pharmaceutical Sciences, vol. 101, no. 3, 2012, pp. 1157-65.
De Melo NF, De Araújo DR, Grillo R, et al. Benzocaine-loaded polymeric nanocapsules: study of the anesthetic activities. J Pharm Sci. 2012;101(3):1157-65.
De Melo, N. F., De Araújo, D. R., Grillo, R., Moraes, C. M., De Matos, A. P., de Paula, E., ... Fraceto, L. F. (2012). Benzocaine-loaded polymeric nanocapsules: study of the anesthetic activities. Journal of Pharmaceutical Sciences, 101(3), pp. 1157-65. doi:10.1002/jps.22829.
De Melo NF, et al. Benzocaine-loaded Polymeric Nanocapsules: Study of the Anesthetic Activities. J Pharm Sci. 2012;101(3):1157-65. PubMed PMID: 22105694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benzocaine-loaded polymeric nanocapsules: study of the anesthetic activities. AU - De Melo,Nathalie Ferreira Silva, AU - De Araújo,Daniele Ribeiro, AU - Grillo,Renato, AU - Moraes,Carolina Morales, AU - De Matos,Angélica Prado, AU - de Paula,Eneida, AU - Rosa,André Henrique, AU - Fraceto,Leonardo Fernandes, Y1 - 2011/11/21/ PY - 2011/06/14/received PY - 2011/09/24/revised PY - 2011/11/02/accepted PY - 2011/11/23/entrez PY - 2011/11/23/pubmed PY - 2012/5/4/medline SP - 1157 EP - 65 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 101 IS - 3 N2 - This paper describes a comparison of different polymeric nanocapsules (NCs) prepared with the polymers poly(D,L-lactide-co-glycolide), poly(L-lactide) (PLA), and poly(ε-caprolactone) and used as carrier systems for the local anesthetic (LA) benzocaine (BZC). The systems were characterized and their anesthetic activities investigated. The results showed particle size distributions with polydispersity indices below 0.135, average diameters up to 120 nm, zeta potentials up to -30 mV, and entrapment efficiencies around 70%. Formulations of BZC using the polymeric NCs presented slower release profiles, compared with that of free BZC. Slowest release (release constant, k = 0.0016 min(-1)) was obtained using the PLA NC system. Pharmacological evaluation showed that encapsulation of BZC in PLA NCs prolonged its anesthetic action. This new formulation could potentially be used in future applications involving the gradual release of local anesthetics (LAs). SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/22105694/Benzocaine_loaded_polymeric_nanocapsules:_study_of_the_anesthetic_activities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(15)31683-X DB - PRIME DP - Unbound Medicine ER -