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Global burden of human food-borne trematodiasis: a systematic review and meta-analysis.
Lancet Infect Dis. 2012 Mar; 12(3):210-21.LI

Abstract

BACKGROUND

Food-borne trematodiases are a group of neglected tropical diseases caused by liver, lung, and intestinal parasitic fluke infections. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD 2010 study) and a WHO initiative, we assessed the global burden of human food-borne trematodiasis, as expressed in disability-adjusted life years (DALYs) for the year 2005.

METHODS

We systematically searched electronic databases for reports about human food-borne trematodiasis without language restriction, between Jan 1, 1980, and Dec 31, 2008. We used a broad search strategy with a combination of search terms and parasite and disease names. The initial search results were then screened on the basis of title, abstract, and, finally, full text. Relevant quantitative and qualitative data on human prevalence, morbidity, and mortality of food-borne trematodiasis were extracted. On the basis of available information on pathological and clinical appearance, we developed simplified disease models and did meta-analyses on the proportions and odds ratios of specified sequelae and estimated the global burden of human food-borne trematodiasis.

FINDINGS

We screened 33,921 articles and identified 181 eligible studies containing quantitative information for inclusion in the meta-analyses. About 56·2 million people were infected with food-borne trematodes in 2005: 7·9 million had severe sequelae and 7158 died, most from cholangiocarcinoma and cerebral infection. Taken together, we estimate that the global burden of food-borne trematodiasis was 665,352 DALYs (lower estimate 479,496 DALYs; upper estimate 859,051 DALYs). Furthermore, knowledge gaps in crucial epidemiological disease parameters and methodological features for estimating the global burden of parasitic diseases that are characterised by highly focal spatial occurrence and scarce and patchy information were highlighted.

INTERPRETATION

Despite making conservative estimates, we found that food-borne trematodiases are an important cluster of neglected diseases.

FUNDING

Swiss National Science Foundation; Institute for Health Metrics and Evaluation.

Authors+Show Affiliations

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Systematic Review

Language

eng

PubMed ID

22108757

Citation

Fürst, Thomas, et al. "Global Burden of Human Food-borne Trematodiasis: a Systematic Review and Meta-analysis." The Lancet. Infectious Diseases, vol. 12, no. 3, 2012, pp. 210-21.
Fürst T, Keiser J, Utzinger J. Global burden of human food-borne trematodiasis: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12(3):210-21.
Fürst, T., Keiser, J., & Utzinger, J. (2012). Global burden of human food-borne trematodiasis: a systematic review and meta-analysis. The Lancet. Infectious Diseases, 12(3), 210-21. https://doi.org/10.1016/S1473-3099(11)70294-8
Fürst T, Keiser J, Utzinger J. Global Burden of Human Food-borne Trematodiasis: a Systematic Review and Meta-analysis. Lancet Infect Dis. 2012;12(3):210-21. PubMed PMID: 22108757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Global burden of human food-borne trematodiasis: a systematic review and meta-analysis. AU - Fürst,Thomas, AU - Keiser,Jennifer, AU - Utzinger,Jürg, Y1 - 2011/11/20/ PY - 2011/11/24/entrez PY - 2011/11/24/pubmed PY - 2012/4/5/medline SP - 210 EP - 21 JF - The Lancet. Infectious diseases JO - Lancet Infect Dis VL - 12 IS - 3 N2 - BACKGROUND: Food-borne trematodiases are a group of neglected tropical diseases caused by liver, lung, and intestinal parasitic fluke infections. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD 2010 study) and a WHO initiative, we assessed the global burden of human food-borne trematodiasis, as expressed in disability-adjusted life years (DALYs) for the year 2005. METHODS: We systematically searched electronic databases for reports about human food-borne trematodiasis without language restriction, between Jan 1, 1980, and Dec 31, 2008. We used a broad search strategy with a combination of search terms and parasite and disease names. The initial search results were then screened on the basis of title, abstract, and, finally, full text. Relevant quantitative and qualitative data on human prevalence, morbidity, and mortality of food-borne trematodiasis were extracted. On the basis of available information on pathological and clinical appearance, we developed simplified disease models and did meta-analyses on the proportions and odds ratios of specified sequelae and estimated the global burden of human food-borne trematodiasis. FINDINGS: We screened 33,921 articles and identified 181 eligible studies containing quantitative information for inclusion in the meta-analyses. About 56·2 million people were infected with food-borne trematodes in 2005: 7·9 million had severe sequelae and 7158 died, most from cholangiocarcinoma and cerebral infection. Taken together, we estimate that the global burden of food-borne trematodiasis was 665,352 DALYs (lower estimate 479,496 DALYs; upper estimate 859,051 DALYs). Furthermore, knowledge gaps in crucial epidemiological disease parameters and methodological features for estimating the global burden of parasitic diseases that are characterised by highly focal spatial occurrence and scarce and patchy information were highlighted. INTERPRETATION: Despite making conservative estimates, we found that food-borne trematodiases are an important cluster of neglected diseases. FUNDING: Swiss National Science Foundation; Institute for Health Metrics and Evaluation. SN - 1474-4457 UR - https://www.unboundmedicine.com/medline/citation/22108757/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1473-3099(11)70294-8 DB - PRIME DP - Unbound Medicine ER -