Tags

Type your tag names separated by a space and hit enter

n-3 fatty acids, ventricular arrhythmia-related events, and fatal myocardial infarction in postmyocardial infarction patients with diabetes.
Diabetes Care 2011; 34(12):2515-20DC

Abstract

OBJECTIVE

We carried out a secondary analysis in high-risk patients with a previous myocardial infarction (MI) and diabetes in the Alpha Omega Trial. We tested the hypothesis that in these patients an increased intake of the n-3 fatty acids eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linolenic acid (ALA) will reduce the incidence of ventricular arrhythmias and fatal MI.

RESEARCH DESIGN AND METHODS

A subgroup of 1,014 post-MI patients with diabetes aged 60-80 years was randomly allocated to receive one of four trial margarines, three with an additional amount of n-3 fatty acids and one placebo for 40 months. The end points were ventricular arrhythmia-related events and fatal MI. The data were analyzed according to the intention-to-treat principle, using multivariable Cox proportional hazards models.

RESULTS

The patients consumed on average 18.6 g of margarine per day, which resulted in an additional intake of 223 mg EPA plus 149 mg DHA and/or 1.9 g ALA in the active treatment groups. During follow-up, 29 patients developed a ventricular arrhythmia-related events and 27 had a fatal MI. Compared with placebo patients, the EPA-DHA plus ALA group experienced less ventricular arrhythmia-related events (hazard ratio 0.16; 95% CI 0.04-0.69). These n-3 fatty acids also reduced the combined end-point ventricular arrhythmia-related events and fatal MI (0.28; 0.11-0.71).

CONCLUSIONS

Our results suggest that low-dose supplementation of n-3 fatty acids exerts a protective effect against ventricular arrhythmia-related events in post-MI patients with diabetes.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands. daan.kromhout@wur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22110169

Citation

Kromhout, Daan, et al. "N-3 Fatty Acids, Ventricular Arrhythmia-related Events, and Fatal Myocardial Infarction in Postmyocardial Infarction Patients With Diabetes." Diabetes Care, vol. 34, no. 12, 2011, pp. 2515-20.
Kromhout D, Geleijnse JM, de Goede J, et al. N-3 fatty acids, ventricular arrhythmia-related events, and fatal myocardial infarction in postmyocardial infarction patients with diabetes. Diabetes Care. 2011;34(12):2515-20.
Kromhout, D., Geleijnse, J. M., de Goede, J., Oude Griep, L. M., Mulder, B. J., de Boer, M. J., ... Giltay, E. J. (2011). N-3 fatty acids, ventricular arrhythmia-related events, and fatal myocardial infarction in postmyocardial infarction patients with diabetes. Diabetes Care, 34(12), pp. 2515-20. doi:10.2337/dc11-0896.
Kromhout D, et al. N-3 Fatty Acids, Ventricular Arrhythmia-related Events, and Fatal Myocardial Infarction in Postmyocardial Infarction Patients With Diabetes. Diabetes Care. 2011;34(12):2515-20. PubMed PMID: 22110169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - n-3 fatty acids, ventricular arrhythmia-related events, and fatal myocardial infarction in postmyocardial infarction patients with diabetes. AU - Kromhout,Daan, AU - Geleijnse,Johanna M, AU - de Goede,Janette, AU - Oude Griep,Linda M, AU - Mulder,Barbara J M, AU - de Boer,Menko-Jan, AU - Deckers,Jaap W, AU - Boersma,Eric, AU - Zock,Peter L, AU - Giltay,Erik J, PY - 2011/11/24/entrez PY - 2011/11/24/pubmed PY - 2012/5/15/medline SP - 2515 EP - 20 JF - Diabetes care JO - Diabetes Care VL - 34 IS - 12 N2 - OBJECTIVE: We carried out a secondary analysis in high-risk patients with a previous myocardial infarction (MI) and diabetes in the Alpha Omega Trial. We tested the hypothesis that in these patients an increased intake of the n-3 fatty acids eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linolenic acid (ALA) will reduce the incidence of ventricular arrhythmias and fatal MI. RESEARCH DESIGN AND METHODS: A subgroup of 1,014 post-MI patients with diabetes aged 60-80 years was randomly allocated to receive one of four trial margarines, three with an additional amount of n-3 fatty acids and one placebo for 40 months. The end points were ventricular arrhythmia-related events and fatal MI. The data were analyzed according to the intention-to-treat principle, using multivariable Cox proportional hazards models. RESULTS: The patients consumed on average 18.6 g of margarine per day, which resulted in an additional intake of 223 mg EPA plus 149 mg DHA and/or 1.9 g ALA in the active treatment groups. During follow-up, 29 patients developed a ventricular arrhythmia-related events and 27 had a fatal MI. Compared with placebo patients, the EPA-DHA plus ALA group experienced less ventricular arrhythmia-related events (hazard ratio 0.16; 95% CI 0.04-0.69). These n-3 fatty acids also reduced the combined end-point ventricular arrhythmia-related events and fatal MI (0.28; 0.11-0.71). CONCLUSIONS: Our results suggest that low-dose supplementation of n-3 fatty acids exerts a protective effect against ventricular arrhythmia-related events in post-MI patients with diabetes. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/22110169/n_3_fatty_acids_ventricular_arrhythmia_related_events_and_fatal_myocardial_infarction_in_postmyocardial_infarction_patients_with_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=22110169 DB - PRIME DP - Unbound Medicine ER -