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Burden of pneumonia and meningitis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review.
PLoS One. 2011; 6(11):e27333.Plos

Abstract

BACKGROUND AND METHODS

To understand the burden and epidemiology of Streptococcus pneumoniae disease among children between 1 and 59 months of age in China, we conducted a review of literature published between 1980 and 2008 applying standardized algorithms. Because of the absence of population-based surveillance for pneumococcal disease (PD), we identified all-cause pneumonia, bacteremia and meningitis burden, syndromes most commonly associated with S. pneumoniae, and applied the proportion of disease attributable to S. pneumoniae from studies that determined the etiology of these three syndromes to calculate PD burden. Because of the microbiologic difficulties in identifying S. pneumoniae-attributable pneumonia which likely underestimates the pneumonia burden, we also used the proportion obtained from vaccine efficacy trials.

RESULTS

Between 1980 and 2008, there were 12,815 cases/100,000/year of all-cause pneumonia among children between 1 month and 59 months, with 526 deaths/100,000 annually. There were 14 meningitis cases/100,000/year. We estimate that as of 2000, there were 260,768 (113,000 to 582,382) and 902 (114-4,463) cases of pneumococcal pneumonia and meningitis, respectively with 10,703 (4,638-23,904) and 75 (9-370) pneumococcal pneumonia and meningitis deaths, respectively. Pneumococcal pneumonia cases and deaths were more than two-fold higher, 695,382 (173,845-1,216,918) and 28,542 (7,136-49,949), respectively, when parameters from efficacy trials were used. Serotypes 19F, 19A and 14 were the most common serotypes obtained from pneumonia/meningitis patients. Currently available vaccines are expected to cover 79.5% to 88.4% of the prevalent serotypes. With high antibiotic resistance, introducing pneumococcal vaccines to the routine immunization program should be considered in China. Population-based studies are warranted.

Authors+Show Affiliations

Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

22110628

Citation

Chen, Ying, et al. "Burden of Pneumonia and Meningitis Caused By Streptococcus Pneumoniae in China Among Children Under 5 Years of Age: a Systematic Literature Review." PloS One, vol. 6, no. 11, 2011, pp. e27333.
Chen Y, Deng W, Wang SM, et al. Burden of pneumonia and meningitis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review. PLoS One. 2011;6(11):e27333.
Chen, Y., Deng, W., Wang, S. M., Mo, Q. M., Jia, H., Wang, Q., Li, S. G., Li, X., Yao, B. D., Liu, C. J., Zhan, Y. Q., Ji, C., Lopez, A. L., & Wang, X. Y. (2011). Burden of pneumonia and meningitis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review. PloS One, 6(11), e27333. https://doi.org/10.1371/journal.pone.0027333
Chen Y, et al. Burden of Pneumonia and Meningitis Caused By Streptococcus Pneumoniae in China Among Children Under 5 Years of Age: a Systematic Literature Review. PLoS One. 2011;6(11):e27333. PubMed PMID: 22110628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burden of pneumonia and meningitis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review. AU - Chen,Ying, AU - Deng,Wei, AU - Wang,Song-Mei, AU - Mo,Qi-Mei, AU - Jia,Huan, AU - Wang,Qun, AU - Li,Song-Guang, AU - Li,Xiang, AU - Yao,Bao-Dong, AU - Liu,Cheng-Jun, AU - Zhan,Yi-Qiang, AU - Ji,Chen, AU - Lopez,Anna Lena, AU - Wang,Xuan-Yi, Y1 - 2011/11/16/ PY - 2011/08/16/received PY - 2011/10/14/accepted PY - 2011/11/24/entrez PY - 2011/11/24/pubmed PY - 2012/3/27/medline SP - e27333 EP - e27333 JF - PloS one JO - PLoS One VL - 6 IS - 11 N2 - BACKGROUND AND METHODS: To understand the burden and epidemiology of Streptococcus pneumoniae disease among children between 1 and 59 months of age in China, we conducted a review of literature published between 1980 and 2008 applying standardized algorithms. Because of the absence of population-based surveillance for pneumococcal disease (PD), we identified all-cause pneumonia, bacteremia and meningitis burden, syndromes most commonly associated with S. pneumoniae, and applied the proportion of disease attributable to S. pneumoniae from studies that determined the etiology of these three syndromes to calculate PD burden. Because of the microbiologic difficulties in identifying S. pneumoniae-attributable pneumonia which likely underestimates the pneumonia burden, we also used the proportion obtained from vaccine efficacy trials. RESULTS: Between 1980 and 2008, there were 12,815 cases/100,000/year of all-cause pneumonia among children between 1 month and 59 months, with 526 deaths/100,000 annually. There were 14 meningitis cases/100,000/year. We estimate that as of 2000, there were 260,768 (113,000 to 582,382) and 902 (114-4,463) cases of pneumococcal pneumonia and meningitis, respectively with 10,703 (4,638-23,904) and 75 (9-370) pneumococcal pneumonia and meningitis deaths, respectively. Pneumococcal pneumonia cases and deaths were more than two-fold higher, 695,382 (173,845-1,216,918) and 28,542 (7,136-49,949), respectively, when parameters from efficacy trials were used. Serotypes 19F, 19A and 14 were the most common serotypes obtained from pneumonia/meningitis patients. Currently available vaccines are expected to cover 79.5% to 88.4% of the prevalent serotypes. With high antibiotic resistance, introducing pneumococcal vaccines to the routine immunization program should be considered in China. Population-based studies are warranted. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22110628/Burden_of_pneumonia_and_meningitis_caused_by_Streptococcus_pneumoniae_in_China_among_children_under_5_years_of_age:_a_systematic_literature_review_ L2 - https://dx.plos.org/10.1371/journal.pone.0027333 DB - PRIME DP - Unbound Medicine ER -