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Oxidative DNA damage correlates with carotid artery atherosclerosis in hemodialysis patients.
Hemodial Int 2011; 15(4):453-9HI

Abstract

Oxidative stress is accepted as a nonclassical cardiovascular risk factor in chronic renal failure patients. The aim of this study was to evaluate the relation between oxidative DNA damage (8-hydroxy-2'-deoxyguanosine/deoxyguanosine [8-OHdG/dG] ratio), oxidative stress biomarkers, antioxidant enzymes, and carotid artery intima-media thickness (CIMT) in hemodialysis (HD) patients. Forty chronic HD patients without known atherosclerotic disease and 48 age- and sex-matched healthy individuals were included in the study. Plasma malondialdehyde (MDA) levels and 8-OHdG/dG ratio were determined as oxidative stress markers. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured as antioxidants. CIMT was assessed by carotid artery ultrasonography. 8-OHdG/dG ratios and MDA levels were higher; SOD and GPx activities were lower in HD patients compared to controls. HD patients had significantly higher CIMT compared to controls (0.61 ± 0.08 vs. 0.42 ± 0.05, p < 0.001). There was a significant positive correlation between CIMT and 8-OHdG/dG ratio (r = 0.57, p < 0.01) and MDA levels (r = 0.41, p < 0.01), while there was a significant negative correlation between CIMT and SOD (r = -0.47, p < 0.01) and GPx levels (r = -0.62, p < 0.01). It is firstly demonstrated that CIMT is positively correlated with oxidative DNA damage in HD patients without known atherosclerotic disease.

Authors+Show Affiliations

Department of Nephrology, Van Yuksek Ihtisas Hospital, Van, Turkey. elifari@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

22111813

Citation

Ari, Elif, et al. "Oxidative DNA Damage Correlates With Carotid Artery Atherosclerosis in Hemodialysis Patients." Hemodialysis International. International Symposium On Home Hemodialysis, vol. 15, no. 4, 2011, pp. 453-9.
Ari E, Kaya Y, Demir H, et al. Oxidative DNA damage correlates with carotid artery atherosclerosis in hemodialysis patients. Hemodial Int. 2011;15(4):453-9.
Ari, E., Kaya, Y., Demir, H., Cebi, A., Alp, H. H., Bakan, E., ... Keskin, S. (2011). Oxidative DNA damage correlates with carotid artery atherosclerosis in hemodialysis patients. Hemodialysis International. International Symposium On Home Hemodialysis, 15(4), pp. 453-9. doi:10.1111/j.1542-4758.2011.00568.x.
Ari E, et al. Oxidative DNA Damage Correlates With Carotid Artery Atherosclerosis in Hemodialysis Patients. Hemodial Int. 2011;15(4):453-9. PubMed PMID: 22111813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative DNA damage correlates with carotid artery atherosclerosis in hemodialysis patients. AU - Ari,Elif, AU - Kaya,Yuksel, AU - Demir,Halit, AU - Cebi,Aysegul, AU - Alp,Hamit Hakan, AU - Bakan,Ebubekir, AU - Odabasi,Dolunay, AU - Keskin,Sıddık, Y1 - 2011/07/18/ PY - 2011/03/01/received PY - 2011/05/01/revised PY - 2011/11/25/entrez PY - 2011/11/25/pubmed PY - 2012/3/16/medline SP - 453 EP - 9 JF - Hemodialysis international. International Symposium on Home Hemodialysis JO - Hemodial Int VL - 15 IS - 4 N2 - Oxidative stress is accepted as a nonclassical cardiovascular risk factor in chronic renal failure patients. The aim of this study was to evaluate the relation between oxidative DNA damage (8-hydroxy-2'-deoxyguanosine/deoxyguanosine [8-OHdG/dG] ratio), oxidative stress biomarkers, antioxidant enzymes, and carotid artery intima-media thickness (CIMT) in hemodialysis (HD) patients. Forty chronic HD patients without known atherosclerotic disease and 48 age- and sex-matched healthy individuals were included in the study. Plasma malondialdehyde (MDA) levels and 8-OHdG/dG ratio were determined as oxidative stress markers. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured as antioxidants. CIMT was assessed by carotid artery ultrasonography. 8-OHdG/dG ratios and MDA levels were higher; SOD and GPx activities were lower in HD patients compared to controls. HD patients had significantly higher CIMT compared to controls (0.61 ± 0.08 vs. 0.42 ± 0.05, p < 0.001). There was a significant positive correlation between CIMT and 8-OHdG/dG ratio (r = 0.57, p < 0.01) and MDA levels (r = 0.41, p < 0.01), while there was a significant negative correlation between CIMT and SOD (r = -0.47, p < 0.01) and GPx levels (r = -0.62, p < 0.01). It is firstly demonstrated that CIMT is positively correlated with oxidative DNA damage in HD patients without known atherosclerotic disease. SN - 1542-4758 UR - https://www.unboundmedicine.com/medline/citation/22111813/Oxidative_DNA_damage_correlates_with_carotid_artery_atherosclerosis_in_hemodialysis_patients_ L2 - https://doi.org/10.1111/j.1542-4758.2011.00568.x DB - PRIME DP - Unbound Medicine ER -