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Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm.
J Am Coll Surg 2012; 214(1):27-32JA

Abstract

BACKGROUND

Biliary intraductal papillary mucinous neoplasm (B-IPMN) has been proposed as a unique clinicopathologic disease with distinct histopathologic features, although wide acceptance remains controversial. A recent consensus conference classified pancreatic IPMN (P-IPMN) into 4 subtypes (ie, gastric, intestinal, pancreatobiliary, oncocytic) based on morphologic appearance and mucin (MUC) staining properties. The aim of this study was to determine whether B-IPMN has similar histopathologic and immunologic subtypes to P-IPMN.

STUDY DESIGN

Specific immunostaining for MUC1, MUC2, and deleted for pancreas cancer, locus 4 were performed on specimens from 19 patients with a histopathologic diagnosis of B-IPMN. Immunostaining patterns of B-IPMN were correlated with histopathology.

RESULTS

Based on histopathology, the following subtypes of B-IPMN were identified: pancreatobiliary n = 9 (47%), intestinal n = 8 (42%), oncocytic n = 2 (11%), and gastric n = 0 (0%). Pancreatobiliary and oncocytic subtypes of B-IPMN were positive for MUC1 and negative for MUC2, and intestinal subtypes were positive for MUC2 and negative for MUC1. Thirteen of the 19 B-IPMN were associated with invasive carcinoma; loss of deleted for pancreas cancer, locus 4 was found in 6 of 13 invasive components and in 3 of 19 noninvasive components of B-IPMN. Five-year survival for patients with resected B-IPMN and invasive carcinoma was 38%, which is similar to that for resected P-IPMN with invasive carcinoma.

CONCLUSIONS

Histopathologic subtypes and type-specific MUC expression patterns of B-IPMN resemble those of P-IPMN. MUC1 expression and/or absence of MUC2 expression, which correlate with aggressive features of P-IPMN, were found in B-IPMN and correlate with invasive B-IPMN. Loss of deleted for pancreas cancer, locus 4 parallels the findings observed in P-IPMN. These findings provide additional support that B-IPMN is a unique entity with similarities to main duct P-IPMN.

Authors+Show Affiliations

Division of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22112419

Citation

Sclabas, Guido M., et al. "Frequency of Subtypes of Biliary Intraductal Papillary Mucinous Neoplasm and Their MUC1, MUC2, and DPC4 Expression Patterns Differ From Pancreatic Intraductal Papillary Mucinous Neoplasm." Journal of the American College of Surgeons, vol. 214, no. 1, 2012, pp. 27-32.
Sclabas GM, Barton JG, Smyrk TC, et al. Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm. J Am Coll Surg. 2012;214(1):27-32.
Sclabas, G. M., Barton, J. G., Smyrk, T. C., Barrett, D. A., Khan, S., Kendrick, M. L., ... Que, F. G. (2012). Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm. Journal of the American College of Surgeons, 214(1), pp. 27-32. doi:10.1016/j.jamcollsurg.2011.09.025.
Sclabas GM, et al. Frequency of Subtypes of Biliary Intraductal Papillary Mucinous Neoplasm and Their MUC1, MUC2, and DPC4 Expression Patterns Differ From Pancreatic Intraductal Papillary Mucinous Neoplasm. J Am Coll Surg. 2012;214(1):27-32. PubMed PMID: 22112419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm. AU - Sclabas,Guido M, AU - Barton,Joshua G, AU - Smyrk,Thomas C, AU - Barrett,David A, AU - Khan,Saboor, AU - Kendrick,Michael L, AU - Reid-Lombardo,Kaye M, AU - Donohue,John H, AU - Nagorney,David M, AU - Que,Florencia G, Y1 - 2011/11/23/ PY - 2011/08/03/received PY - 2011/09/27/revised PY - 2011/09/30/accepted PY - 2011/11/25/entrez PY - 2011/11/25/pubmed PY - 2012/2/14/medline SP - 27 EP - 32 JF - Journal of the American College of Surgeons JO - J. Am. Coll. Surg. VL - 214 IS - 1 N2 - BACKGROUND: Biliary intraductal papillary mucinous neoplasm (B-IPMN) has been proposed as a unique clinicopathologic disease with distinct histopathologic features, although wide acceptance remains controversial. A recent consensus conference classified pancreatic IPMN (P-IPMN) into 4 subtypes (ie, gastric, intestinal, pancreatobiliary, oncocytic) based on morphologic appearance and mucin (MUC) staining properties. The aim of this study was to determine whether B-IPMN has similar histopathologic and immunologic subtypes to P-IPMN. STUDY DESIGN: Specific immunostaining for MUC1, MUC2, and deleted for pancreas cancer, locus 4 were performed on specimens from 19 patients with a histopathologic diagnosis of B-IPMN. Immunostaining patterns of B-IPMN were correlated with histopathology. RESULTS: Based on histopathology, the following subtypes of B-IPMN were identified: pancreatobiliary n = 9 (47%), intestinal n = 8 (42%), oncocytic n = 2 (11%), and gastric n = 0 (0%). Pancreatobiliary and oncocytic subtypes of B-IPMN were positive for MUC1 and negative for MUC2, and intestinal subtypes were positive for MUC2 and negative for MUC1. Thirteen of the 19 B-IPMN were associated with invasive carcinoma; loss of deleted for pancreas cancer, locus 4 was found in 6 of 13 invasive components and in 3 of 19 noninvasive components of B-IPMN. Five-year survival for patients with resected B-IPMN and invasive carcinoma was 38%, which is similar to that for resected P-IPMN with invasive carcinoma. CONCLUSIONS: Histopathologic subtypes and type-specific MUC expression patterns of B-IPMN resemble those of P-IPMN. MUC1 expression and/or absence of MUC2 expression, which correlate with aggressive features of P-IPMN, were found in B-IPMN and correlate with invasive B-IPMN. Loss of deleted for pancreas cancer, locus 4 parallels the findings observed in P-IPMN. These findings provide additional support that B-IPMN is a unique entity with similarities to main duct P-IPMN. SN - 1879-1190 UR - https://www.unboundmedicine.com/medline/citation/22112419/Frequency_of_subtypes_of_biliary_intraductal_papillary_mucinous_neoplasm_and_their_MUC1_MUC2_and_DPC4_expression_patterns_differ_from_pancreatic_intraductal_papillary_mucinous_neoplasm_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1072-7515(11)01146-X DB - PRIME DP - Unbound Medicine ER -