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Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin.
Phytomedicine. 2012 Feb 15; 19(3-4):364-8.P

Abstract

An endophytic fungus, strain L18, isolated from the medicinal plant Curcuma wenyujin Y.H. Chen et C. Ling was identified as Chaetomium globosum Kunze based on morphological characteristics and sequence data for the internal transcribed spacer (ITS-5.8S-ITS2) of the nuclear ribosomal DNA. A new metabolite named chaetoglobosin X (1), together with three known compounds erogosterol (2), ergosterol 5α,8-peroside (3) and 2-methyl-3-hydroxy indole (4), were isolated from C. globosum L18. Their structures were elucidated by spectroscopic methods including NMR, UV, IR and MS data and comparison with published data. Chaetoglobosin X (1) is hitherto unknown, whereas 2-methyl-3-hydroxy indole (4) is reported for the first time as a fungal metabolite, and erogosterol (2) and ergosterol 5α,8-peroside (3) are known fungal metabolites previously identified in other genera. Chaetoglobosin X (1) exhibited a broader antifungal spectrum and showed the strongest cytotoxic activity against H22 and MFC cancer cell lines.

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Publisher Full Text

Authors+Show Affiliations

Wang Y
Ginseng and Velvet Antler Products Quality Supervision & Test Center Certificated by Ministry of Agriculture, Jilin Agricultural University, 130118 Changchun, PR China.
Xu L
No affiliation info available
Ren W
No affiliation info available
Zhao D
No affiliation info available
Zhu Y
No affiliation info available
Wu X
No affiliation info available

MeSH

AnimalsAntifungal AgentsAntineoplastic AgentsCell Line, TumorChaetomiumCurcumaDNA, FungalDNA, Ribosomal SpacerEndophytesErgosterolIndole AlkaloidsMagnetic Resonance SpectroscopyMiceMicrobial Sensitivity TestsPlant LeavesRibosomes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22112725

Citation

Wang, Yanhong, et al. "Bioactive Metabolites From Chaetomium Globosum L18, an Endophytic Fungus in the Medicinal Plant Curcuma Wenyujin." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 19, no. 3-4, 2012, pp. 364-8.
Wang Y, Xu L, Ren W, et al. Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. Phytomedicine. 2012;19(3-4):364-8.
Wang, Y., Xu, L., Ren, W., Zhao, D., Zhu, Y., & Wu, X. (2012). Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 19(3-4), 364-8. https://doi.org/10.1016/j.phymed.2011.10.011
Wang Y, et al. Bioactive Metabolites From Chaetomium Globosum L18, an Endophytic Fungus in the Medicinal Plant Curcuma Wenyujin. Phytomedicine. 2012 Feb 15;19(3-4):364-8. PubMed PMID: 22112725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. AU - Wang,Yanhong, AU - Xu,Lei, AU - Ren,Weiming, AU - Zhao,Dan, AU - Zhu,Yanping, AU - Wu,Xiaomin, Y1 - 2011/11/22/ PY - 2011/05/19/received PY - 2011/08/04/revised PY - 2011/10/24/accepted PY - 2011/11/25/entrez PY - 2011/11/25/pubmed PY - 2012/5/30/medline SP - 364 EP - 8 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 19 IS - 3-4 N2 - An endophytic fungus, strain L18, isolated from the medicinal plant Curcuma wenyujin Y.H. Chen et C. Ling was identified as Chaetomium globosum Kunze based on morphological characteristics and sequence data for the internal transcribed spacer (ITS-5.8S-ITS2) of the nuclear ribosomal DNA. A new metabolite named chaetoglobosin X (1), together with three known compounds erogosterol (2), ergosterol 5α,8-peroside (3) and 2-methyl-3-hydroxy indole (4), were isolated from C. globosum L18. Their structures were elucidated by spectroscopic methods including NMR, UV, IR and MS data and comparison with published data. Chaetoglobosin X (1) is hitherto unknown, whereas 2-methyl-3-hydroxy indole (4) is reported for the first time as a fungal metabolite, and erogosterol (2) and ergosterol 5α,8-peroside (3) are known fungal metabolites previously identified in other genera. Chaetoglobosin X (1) exhibited a broader antifungal spectrum and showed the strongest cytotoxic activity against H22 and MFC cancer cell lines. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/22112725/Bioactive_metabolites_from_Chaetomium_globosum_L18_an_endophytic_fungus_in_the_medicinal_plant_Curcuma_wenyujin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(11)00523-X DB - PRIME DP - Unbound Medicine ER -