Tags

Type your tag names separated by a space and hit enter

Statistical analysis of Stevens-Johnson syndrome caused by Mycoplasma pneumonia infection in Japan.
Allergol Int. 2011 Dec; 60(4):525-32.AI

Abstract

BACKGROUND

Stevens-Johnson syndrome (SJS) associated with Mycoplasma pneumoniae (M. pneumoniae) infection is mainly observed in children. In adults, drugs are a major cause of SJS, but some adult patients with SJS are infected with M. pneumoniae. We analyzed patients with SJS associated with M. pneumoniae infection to elucidate the differences between drug-induced SJS and M. pneumoniae-associated SJS and also to study differences between M. pneumoniae-associated SJS in children and adults.

METHODS

This is a retrospective review of Japanese patients who have been reported as M. pneumoniae-associated SJS in medical Journals published from 1981 to 2009, compared with data of Japanese patients with drug-induced SJS reported from 2000 to 2009.

RESULTS

Thirty-eight cases of M. pneumoniae-associated SJS and 78 cases of drug-induced SJS were analyzed in this study. Ocular lesions were observed more frequently in M. pneumoniae-associated SJS than in drug-induced SJS (p < 0.01), and adult patients showed a higher ratio of sequelae in their eyes than did patients under 20 years of age (p < 0.01). Sixty-six percent of adult patients with M. pneumoniae-associated SJS developed fever/respiratory symptoms and mucocutaneous lesions on the same day. In contrast, most of the patients under 20 years of age developed fever/respiratory symptoms before mucocutaneous involvement. This means that these adult patients were infected and immunized previously and developed allergic reactions to M. pneumoniae soon after the later infection.

CONCLUSIONS

In order to prevent ocular sequelae in adult patients when M. pneumoniae infection is suspected, more intensive treatment may be needed in adult patients than in younger patients.

Authors+Show Affiliations

Department of Immuno-dermatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan. yukowata@yokohama-cu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22113160

Citation

Kunimi, Yuko, et al. "Statistical Analysis of Stevens-Johnson Syndrome Caused By Mycoplasma Pneumonia Infection in Japan." Allergology International : Official Journal of the Japanese Society of Allergology, vol. 60, no. 4, 2011, pp. 525-32.
Kunimi Y, Hirata Y, Aihara M, et al. Statistical analysis of Stevens-Johnson syndrome caused by Mycoplasma pneumonia infection in Japan. Allergol Int. 2011;60(4):525-32.
Kunimi, Y., Hirata, Y., Aihara, M., Yamane, Y., & Ikezawa, Z. (2011). Statistical analysis of Stevens-Johnson syndrome caused by Mycoplasma pneumonia infection in Japan. Allergology International : Official Journal of the Japanese Society of Allergology, 60(4), 525-32. https://doi.org/10.2332/allergolint.11-OA-0309
Kunimi Y, et al. Statistical Analysis of Stevens-Johnson Syndrome Caused By Mycoplasma Pneumonia Infection in Japan. Allergol Int. 2011;60(4):525-32. PubMed PMID: 22113160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statistical analysis of Stevens-Johnson syndrome caused by Mycoplasma pneumonia infection in Japan. AU - Kunimi,Yuko, AU - Hirata,Yuko, AU - Aihara,Michiko, AU - Yamane,Yumiko, AU - Ikezawa,Zenro, PY - 2011/02/16/received PY - 2011/03/31/accepted PY - 2011/11/25/entrez PY - 2011/11/25/pubmed PY - 2012/5/1/medline SP - 525 EP - 32 JF - Allergology international : official journal of the Japanese Society of Allergology JO - Allergol Int VL - 60 IS - 4 N2 - BACKGROUND: Stevens-Johnson syndrome (SJS) associated with Mycoplasma pneumoniae (M. pneumoniae) infection is mainly observed in children. In adults, drugs are a major cause of SJS, but some adult patients with SJS are infected with M. pneumoniae. We analyzed patients with SJS associated with M. pneumoniae infection to elucidate the differences between drug-induced SJS and M. pneumoniae-associated SJS and also to study differences between M. pneumoniae-associated SJS in children and adults. METHODS: This is a retrospective review of Japanese patients who have been reported as M. pneumoniae-associated SJS in medical Journals published from 1981 to 2009, compared with data of Japanese patients with drug-induced SJS reported from 2000 to 2009. RESULTS: Thirty-eight cases of M. pneumoniae-associated SJS and 78 cases of drug-induced SJS were analyzed in this study. Ocular lesions were observed more frequently in M. pneumoniae-associated SJS than in drug-induced SJS (p < 0.01), and adult patients showed a higher ratio of sequelae in their eyes than did patients under 20 years of age (p < 0.01). Sixty-six percent of adult patients with M. pneumoniae-associated SJS developed fever/respiratory symptoms and mucocutaneous lesions on the same day. In contrast, most of the patients under 20 years of age developed fever/respiratory symptoms before mucocutaneous involvement. This means that these adult patients were infected and immunized previously and developed allergic reactions to M. pneumoniae soon after the later infection. CONCLUSIONS: In order to prevent ocular sequelae in adult patients when M. pneumoniae infection is suspected, more intensive treatment may be needed in adult patients than in younger patients. SN - 1440-1592 UR - https://www.unboundmedicine.com/medline/citation/22113160/Statistical_analysis_of_Stevens_Johnson_syndrome_caused_by_Mycoplasma_pneumonia_infection_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1323-8930(15)30562-1 DB - PRIME DP - Unbound Medicine ER -