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Cardiac autonomic function in acutely nitric oxide deficient hypertensive rats: role of the sympathetic nervous system and oxidative stress.
Can J Physiol Pharmacol. 2011 Dec; 89(12):865-74.CJ

Abstract

We evaluated the role of the sympathetic nervous system and oxidative stress in hemodynamic and autonomic control after acute inhibition of the synthesis of nitric oxide, using intravenous (i.v.) injection of 30 mg·kg(-1) N(G)-nitro-l-arginine methyl ester (L-NAME) in adult Wistar rats. Baroreflex sensitivity (BRS) and heart rate variability (HRV) were measured as indices of cardiac autonomic control, before and after L-NAME treatment in rats with intact autonomic innervation, and in rats with chemical sympathectomy by 6-hydroxydopamine. Serum malondialdehyde (MDA) was measured as a marker of oxidative stress. In control rats, L-NAME treatment resulted in a significant rise in blood pressure, augmentation of BRS, and enhanced serum MDA. HRV showed an attenuation of total spectral power and high frequency spectral power, along with a rise of the low to high frequency ratio (LF:HF). Administration of L-NAME produced a pressor response even in sympathectomised rats, but augmented BRS was not observed, and the high frequency spectral power showed an increase, in addition to a significant decline of LF:HF and serum MDA. We therefore conclude that even though pressor response was unaffected, reversal of cardiac autonomic responses and decline in oxidative stress following sympathectomy in L-NAME-treated rats reflects a significant role for sympathetic innervation in acute L-NAME-induced hypertension.

Authors+Show Affiliations

a Department of Physiology, Vardhaman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22115075

Citation

Chaswal, Meenakshi, et al. "Cardiac Autonomic Function in Acutely Nitric Oxide Deficient Hypertensive Rats: Role of the Sympathetic Nervous System and Oxidative Stress." Canadian Journal of Physiology and Pharmacology, vol. 89, no. 12, 2011, pp. 865-74.
Chaswal M, Das S, Prasad J, et al. Cardiac autonomic function in acutely nitric oxide deficient hypertensive rats: role of the sympathetic nervous system and oxidative stress. Can J Physiol Pharmacol. 2011;89(12):865-74.
Chaswal, M., Das, S., Prasad, J., Katyal, A., & Fahim, M. (2011). Cardiac autonomic function in acutely nitric oxide deficient hypertensive rats: role of the sympathetic nervous system and oxidative stress. Canadian Journal of Physiology and Pharmacology, 89(12), 865-74. https://doi.org/10.1139/y11-084
Chaswal M, et al. Cardiac Autonomic Function in Acutely Nitric Oxide Deficient Hypertensive Rats: Role of the Sympathetic Nervous System and Oxidative Stress. Can J Physiol Pharmacol. 2011;89(12):865-74. PubMed PMID: 22115075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac autonomic function in acutely nitric oxide deficient hypertensive rats: role of the sympathetic nervous system and oxidative stress. AU - Chaswal,Meenakshi, AU - Das,Shobha, AU - Prasad,Jagdish, AU - Katyal,Anju, AU - Fahim,Mohammad, Y1 - 2011/11/24/ PY - 2011/11/26/entrez PY - 2011/11/26/pubmed PY - 2014/12/17/medline SP - 865 EP - 74 JF - Canadian journal of physiology and pharmacology JO - Can J Physiol Pharmacol VL - 89 IS - 12 N2 - We evaluated the role of the sympathetic nervous system and oxidative stress in hemodynamic and autonomic control after acute inhibition of the synthesis of nitric oxide, using intravenous (i.v.) injection of 30 mg·kg(-1) N(G)-nitro-l-arginine methyl ester (L-NAME) in adult Wistar rats. Baroreflex sensitivity (BRS) and heart rate variability (HRV) were measured as indices of cardiac autonomic control, before and after L-NAME treatment in rats with intact autonomic innervation, and in rats with chemical sympathectomy by 6-hydroxydopamine. Serum malondialdehyde (MDA) was measured as a marker of oxidative stress. In control rats, L-NAME treatment resulted in a significant rise in blood pressure, augmentation of BRS, and enhanced serum MDA. HRV showed an attenuation of total spectral power and high frequency spectral power, along with a rise of the low to high frequency ratio (LF:HF). Administration of L-NAME produced a pressor response even in sympathectomised rats, but augmented BRS was not observed, and the high frequency spectral power showed an increase, in addition to a significant decline of LF:HF and serum MDA. We therefore conclude that even though pressor response was unaffected, reversal of cardiac autonomic responses and decline in oxidative stress following sympathectomy in L-NAME-treated rats reflects a significant role for sympathetic innervation in acute L-NAME-induced hypertension. SN - 1205-7541 UR - https://www.unboundmedicine.com/medline/citation/22115075/Cardiac_autonomic_function_in_acutely_nitric_oxide_deficient_hypertensive_rats:_role_of_the_sympathetic_nervous_system_and_oxidative_stress_ L2 - https://cdnsciencepub.com/doi/10.1139/y11-084?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -