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Association of dietary fat intakes with risk of esophageal and gastric cancer in the NIH-AARP diet and health study.

Abstract

The aim of our study was to investigate whether intakes of total fat and fat subtypes were associated with esophageal adenocarcinoma (EAC), esophageal squamous cell carcinoma (ESCC), gastric cardia or gastric noncardia adenocarcinoma. From 1995-1996, dietary intake data was reported by 494,978 participants of the NIH-AARP cohort. The 630 EAC, 215 ESCC, 454 gastric cardia and 501 gastric noncardia adenocarcinomas accrued to the cohort. Cox proportional hazards regression was used to examine the association between the dietary fat intakes, whilst adjusting for potential confounders. Although apparent associations were observed in energy-adjusted models, multivariate adjustment attenuated results to null [e.g., EAC energy adjusted hazard ratio (HR) and 95% confidence interval (95% CI) 1.66 (1.27-2.18) p for trend <0.01; EAC multivariate adjusted HR (95% CI) 1.17 (0.84-1.64) p for trend = 0.58]. Similar patterns were also observed for fat subtypes [e.g., EAC saturated fat, energy adjusted HR (95% CI) 1.79 (1.37-2.33) p for trend <0.01; EAC saturated fat, multivariate adjusted HR (95% CI) 1.27 (0.91-1.78) p for trend = 0.28]. However, in multivariate models an inverse association for polyunsaturated fat (continuous) was seen for EAC in subjects with a body mass index (BMI) in the normal range (18.5-<25 kg/m(2)) [HR (95% CI) 0.76 (0.63-0.92)], that was not present in overweight subjects [HR (95% CI) 1.04 (0.96-1.14)], or in unstratified analysis [HR (95% CI) 0.97 (0.90-1.05)]. p for interaction = 0.02. Overall, we found null associations between the dietary fat intakes with esophageal or gastric cancer risk; although a protective effect of polyunsaturated fat intake was seen for EAC in subjects with a normal BMI.

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  • Authors+Show Affiliations

    ,

    Cancer Epidemiology Health Services Research Group, Centre for Public Health, Queens University Belfast, Belfast, Northern Ireland, United Kingdom. m.odoherty@qub.ac.uk

    , , , , ,

    Source

    International journal of cancer 131:6 2012 Sep 15 pg 1376-87

    MeSH

    Adenocarcinoma
    Aged
    Carcinoma, Squamous Cell
    Cardia
    Dietary Fats
    Esophageal Neoplasms
    Female
    Humans
    Male
    Middle Aged
    National Institutes of Health (U.S.)
    Proportional Hazards Models
    Prospective Studies
    Stomach Neoplasms
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22116732

    Citation

    O'Doherty, Mark G., et al. "Association of Dietary Fat Intakes With Risk of Esophageal and Gastric Cancer in the NIH-AARP Diet and Health Study." International Journal of Cancer, vol. 131, no. 6, 2012, pp. 1376-87.
    O'Doherty MG, Freedman ND, Hollenbeck AR, et al. Association of dietary fat intakes with risk of esophageal and gastric cancer in the NIH-AARP diet and health study. Int J Cancer. 2012;131(6):1376-87.
    O'Doherty, M. G., Freedman, N. D., Hollenbeck, A. R., Schatzkin, A., Murray, L. J., Cantwell, M. M., & Abnet, C. C. (2012). Association of dietary fat intakes with risk of esophageal and gastric cancer in the NIH-AARP diet and health study. International Journal of Cancer, 131(6), pp. 1376-87. doi:10.1002/ijc.27366.
    O'Doherty MG, et al. Association of Dietary Fat Intakes With Risk of Esophageal and Gastric Cancer in the NIH-AARP Diet and Health Study. Int J Cancer. 2012 Sep 15;131(6):1376-87. PubMed PMID: 22116732.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of dietary fat intakes with risk of esophageal and gastric cancer in the NIH-AARP diet and health study. AU - O'Doherty,Mark G, AU - Freedman,Neal D, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, AU - Murray,Liam J, AU - Cantwell,Marie M, AU - Abnet,Christian C, Y1 - 2012/01/27/ PY - 2011/05/30/received PY - 2011/11/15/accepted PY - 2011/11/26/entrez PY - 2011/11/26/pubmed PY - 2013/3/12/medline SP - 1376 EP - 87 JF - International journal of cancer JO - Int. J. Cancer VL - 131 IS - 6 N2 - The aim of our study was to investigate whether intakes of total fat and fat subtypes were associated with esophageal adenocarcinoma (EAC), esophageal squamous cell carcinoma (ESCC), gastric cardia or gastric noncardia adenocarcinoma. From 1995-1996, dietary intake data was reported by 494,978 participants of the NIH-AARP cohort. The 630 EAC, 215 ESCC, 454 gastric cardia and 501 gastric noncardia adenocarcinomas accrued to the cohort. Cox proportional hazards regression was used to examine the association between the dietary fat intakes, whilst adjusting for potential confounders. Although apparent associations were observed in energy-adjusted models, multivariate adjustment attenuated results to null [e.g., EAC energy adjusted hazard ratio (HR) and 95% confidence interval (95% CI) 1.66 (1.27-2.18) p for trend <0.01; EAC multivariate adjusted HR (95% CI) 1.17 (0.84-1.64) p for trend = 0.58]. Similar patterns were also observed for fat subtypes [e.g., EAC saturated fat, energy adjusted HR (95% CI) 1.79 (1.37-2.33) p for trend <0.01; EAC saturated fat, multivariate adjusted HR (95% CI) 1.27 (0.91-1.78) p for trend = 0.28]. However, in multivariate models an inverse association for polyunsaturated fat (continuous) was seen for EAC in subjects with a body mass index (BMI) in the normal range (18.5-<25 kg/m(2)) [HR (95% CI) 0.76 (0.63-0.92)], that was not present in overweight subjects [HR (95% CI) 1.04 (0.96-1.14)], or in unstratified analysis [HR (95% CI) 0.97 (0.90-1.05)]. p for interaction = 0.02. Overall, we found null associations between the dietary fat intakes with esophageal or gastric cancer risk; although a protective effect of polyunsaturated fat intake was seen for EAC in subjects with a normal BMI. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/22116732/Association_of_dietary_fat_intakes_with_risk_of_esophageal_and_gastric_cancer_in_the_NIH_AARP_diet_and_health_study_ L2 - https://doi.org/10.1002/ijc.27366 DB - PRIME DP - Unbound Medicine ER -