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Self-reported symptoms in patients on hemodialysis with moderate to severe secondary hyperparathyroidism receiving combined therapy with cinacalcet and low-dose vitamin D sterols.
Hemodial Int. 2012 Apr; 16(2):188-97.HI

Abstract

Patients with secondary hyperparathyroidism experience a variety of clinical symptoms which may adversely affect physical and mental function. As part of a multicenter, open-label clinical trial, subjects completed a questionnaire that included the Medical Outcomes Study Short Form-36 and 14 kidney disease-related symptoms at multiple time points during the study. Out of the 567 subjects who received at least one dose of cinacalcet, 528 to 535 (93.8-94.4%) completed all or portions of the questionnaire at baseline. The median bioactive parathyroid hormone (PTH) was 294 pg/mL (10%, 90% range, 172-655 pg/mL). Following treatment with cinacalcet and low-dose vitamin D sterols, subjects reported significant improvement in the frequency of pain in muscles, joints and bones, stiff joints, dry skin, itchy skin, excessive thirst, and trouble with memory. At end of the efficacy assessment phase (Weeks 16 to 22), the magnitude of improvement was the greatest in joint pain, bone pain, dry skin, and excessive thirst (>5 on a 0-100 scale; P < 0.001). There were no clinically or statistically significant changes in any of the Short Form-36 subscales or in the physical or mental health composite scores. Among patients on hemodialysis with moderate to severe secondary hyperparathyroidism, treatment with cinacalcet and low-dose vitamin D sterols results in significant improvement in pain in the muscles, joints and bones, joint stiffness, dry and itchy skin, excessive thirst, and trouble with memory.

Authors+Show Affiliations

Division of Nephrology, Stanford University School of Medicine, Palo Alto, California 94304, USA. gchertow@stanford.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22118402

Citation

Chertow, Glenn M., et al. "Self-reported Symptoms in Patients On Hemodialysis With Moderate to Severe Secondary Hyperparathyroidism Receiving Combined Therapy With Cinacalcet and Low-dose Vitamin D Sterols." Hemodialysis International. International Symposium On Home Hemodialysis, vol. 16, no. 2, 2012, pp. 188-97.
Chertow GM, Lu ZJ, Xu X, et al. Self-reported symptoms in patients on hemodialysis with moderate to severe secondary hyperparathyroidism receiving combined therapy with cinacalcet and low-dose vitamin D sterols. Hemodial Int. 2012;16(2):188-97.
Chertow, G. M., Lu, Z. J., Xu, X., Knight, T. G., Goodman, W. G., Bushinsky, D. A., & Block, G. A. (2012). Self-reported symptoms in patients on hemodialysis with moderate to severe secondary hyperparathyroidism receiving combined therapy with cinacalcet and low-dose vitamin D sterols. Hemodialysis International. International Symposium On Home Hemodialysis, 16(2), 188-97. https://doi.org/10.1111/j.1542-4758.2011.00642.x
Chertow GM, et al. Self-reported Symptoms in Patients On Hemodialysis With Moderate to Severe Secondary Hyperparathyroidism Receiving Combined Therapy With Cinacalcet and Low-dose Vitamin D Sterols. Hemodial Int. 2012;16(2):188-97. PubMed PMID: 22118402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-reported symptoms in patients on hemodialysis with moderate to severe secondary hyperparathyroidism receiving combined therapy with cinacalcet and low-dose vitamin D sterols. AU - Chertow,Glenn M, AU - Lu,Z John, AU - Xu,Xiao, AU - Knight,Tyler G, AU - Goodman,William G, AU - Bushinsky,David A, AU - Block,Geoffrey A, PY - 2011/11/29/entrez PY - 2011/11/29/pubmed PY - 2013/1/10/medline SP - 188 EP - 97 JF - Hemodialysis international. International Symposium on Home Hemodialysis JO - Hemodial Int VL - 16 IS - 2 N2 - Patients with secondary hyperparathyroidism experience a variety of clinical symptoms which may adversely affect physical and mental function. As part of a multicenter, open-label clinical trial, subjects completed a questionnaire that included the Medical Outcomes Study Short Form-36 and 14 kidney disease-related symptoms at multiple time points during the study. Out of the 567 subjects who received at least one dose of cinacalcet, 528 to 535 (93.8-94.4%) completed all or portions of the questionnaire at baseline. The median bioactive parathyroid hormone (PTH) was 294 pg/mL (10%, 90% range, 172-655 pg/mL). Following treatment with cinacalcet and low-dose vitamin D sterols, subjects reported significant improvement in the frequency of pain in muscles, joints and bones, stiff joints, dry skin, itchy skin, excessive thirst, and trouble with memory. At end of the efficacy assessment phase (Weeks 16 to 22), the magnitude of improvement was the greatest in joint pain, bone pain, dry skin, and excessive thirst (>5 on a 0-100 scale; P < 0.001). There were no clinically or statistically significant changes in any of the Short Form-36 subscales or in the physical or mental health composite scores. Among patients on hemodialysis with moderate to severe secondary hyperparathyroidism, treatment with cinacalcet and low-dose vitamin D sterols results in significant improvement in pain in the muscles, joints and bones, joint stiffness, dry and itchy skin, excessive thirst, and trouble with memory. SN - 1542-4758 UR - https://www.unboundmedicine.com/medline/citation/22118402/Self_reported_symptoms_in_patients_on_hemodialysis_with_moderate_to_severe_secondary_hyperparathyroidism_receiving_combined_therapy_with_cinacalcet_and_low_dose_vitamin_D_sterols_ L2 - https://doi.org/10.1111/j.1542-4758.2011.00642.x DB - PRIME DP - Unbound Medicine ER -