Tags

Type your tag names separated by a space and hit enter

Oxidized high-density lipoprotein as a risk factor for cardiovascular events in prevalent hemodialysis patients.
Atherosclerosis. 2012 Feb; 220(2):493-501.A

Abstract

BACKGROUND AND OBJECTIVES

Here, we assessed the impact of oxidized high-density lipoprotein (oxHDL), dysfunctional HDL, on mortality and cardiovascular disease (CVD) events in prevalent HD patients and compared oxHDL to interleukin-6 (IL-6), a strong predictor of CVD events in HD patients.

DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS

This prospective study examined a cohort of prevalent HD patients (n=412). Blood samples were obtained at baseline to measure lipids, high-sensitive C-reactive protein (hsCRP), IL-6, oxidized low-density lipoprotein, N-terminal pro B-type natriuretic peptide, intercellular adhesion molecule 1 (ICAM-1), myeloperoxidase, adiponectin, and oxHDL. Carotid intima-media thickness (CIMT) was assessed at baseline and 3-year follow-up. Nutritional status was assessed by subjective global assessment (SGA), body mass index, and geriatric nutritional risk index (GNRI). After the baseline assessment, study patients were prospectively followed up (mean observational period, 40 months).

RESULTS

At baseline, patients with high oxHDL had a worse nutritional state and higher HDL-cholesterol (HDL-chol), ICAM-1, and adiponectin levels and a higher oxHDL/HDL-chol ratio than low oxHDL patients. A combination of high oxHDL and high IL-6 was significantly associated with increased CIMT at baseline and a larger increase in CIMT at 3-year follow-up. High oxHDL did not predict all-cause mortality; however, it was significantly associated with CVD-related mortality and composite CVD events, particularly with concomitant high IL-6. These associations were confirmed in multivariate Cox hazard models adjusted with confounding variables.

CONCLUSIONS

High oxHDL, particularly with concomitant high IL-6, may be associated with an increased risk of CVD events and CVD-related mortality in prevalent HD patients.

Authors+Show Affiliations

Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. hondah@med.showa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22119537

Citation

Honda, Hirokazu, et al. "Oxidized High-density Lipoprotein as a Risk Factor for Cardiovascular Events in Prevalent Hemodialysis Patients." Atherosclerosis, vol. 220, no. 2, 2012, pp. 493-501.
Honda H, Ueda M, Kojima S, et al. Oxidized high-density lipoprotein as a risk factor for cardiovascular events in prevalent hemodialysis patients. Atherosclerosis. 2012;220(2):493-501.
Honda, H., Ueda, M., Kojima, S., Mashiba, S., Michihata, T., Takahashi, K., Shishido, K., & Akizawa, T. (2012). Oxidized high-density lipoprotein as a risk factor for cardiovascular events in prevalent hemodialysis patients. Atherosclerosis, 220(2), 493-501. https://doi.org/10.1016/j.atherosclerosis.2011.10.038
Honda H, et al. Oxidized High-density Lipoprotein as a Risk Factor for Cardiovascular Events in Prevalent Hemodialysis Patients. Atherosclerosis. 2012;220(2):493-501. PubMed PMID: 22119537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized high-density lipoprotein as a risk factor for cardiovascular events in prevalent hemodialysis patients. AU - Honda,Hirokazu, AU - Ueda,Masashi, AU - Kojima,Shiho, AU - Mashiba,Shinichi, AU - Michihata,Tetsuo, AU - Takahashi,Keiko, AU - Shishido,Kanji, AU - Akizawa,Tadao, Y1 - 2011/11/03/ PY - 2011/06/01/received PY - 2011/10/13/revised PY - 2011/10/25/accepted PY - 2011/11/29/entrez PY - 2011/11/29/pubmed PY - 2012/5/23/medline SP - 493 EP - 501 JF - Atherosclerosis JO - Atherosclerosis VL - 220 IS - 2 N2 - BACKGROUND AND OBJECTIVES: Here, we assessed the impact of oxidized high-density lipoprotein (oxHDL), dysfunctional HDL, on mortality and cardiovascular disease (CVD) events in prevalent HD patients and compared oxHDL to interleukin-6 (IL-6), a strong predictor of CVD events in HD patients. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: This prospective study examined a cohort of prevalent HD patients (n=412). Blood samples were obtained at baseline to measure lipids, high-sensitive C-reactive protein (hsCRP), IL-6, oxidized low-density lipoprotein, N-terminal pro B-type natriuretic peptide, intercellular adhesion molecule 1 (ICAM-1), myeloperoxidase, adiponectin, and oxHDL. Carotid intima-media thickness (CIMT) was assessed at baseline and 3-year follow-up. Nutritional status was assessed by subjective global assessment (SGA), body mass index, and geriatric nutritional risk index (GNRI). After the baseline assessment, study patients were prospectively followed up (mean observational period, 40 months). RESULTS: At baseline, patients with high oxHDL had a worse nutritional state and higher HDL-cholesterol (HDL-chol), ICAM-1, and adiponectin levels and a higher oxHDL/HDL-chol ratio than low oxHDL patients. A combination of high oxHDL and high IL-6 was significantly associated with increased CIMT at baseline and a larger increase in CIMT at 3-year follow-up. High oxHDL did not predict all-cause mortality; however, it was significantly associated with CVD-related mortality and composite CVD events, particularly with concomitant high IL-6. These associations were confirmed in multivariate Cox hazard models adjusted with confounding variables. CONCLUSIONS: High oxHDL, particularly with concomitant high IL-6, may be associated with an increased risk of CVD events and CVD-related mortality in prevalent HD patients. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/22119537/Oxidized_high_density_lipoprotein_as_a_risk_factor_for_cardiovascular_events_in_prevalent_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(11)01028-8 DB - PRIME DP - Unbound Medicine ER -