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A diet enriched in docosahexanoic Acid exacerbates brain parenchymal extravasation of apo B lipoproteins induced by chronic ingestion of saturated fats.
Int J Vasc Med 2012; 2012:647689IJ

Abstract

Chronic ingestion of saturated fatty acids (SFAs) was previously shown to compromise blood-brain barrier integrity, leading to brain parenchymal extravasation of apolipoprotein B (apo B) lipoproteins enriched in amyloid beta. In contrast, diets enriched in mono- or polyunsaturated (PUFA) oils had no detrimental effect. Rather, n3 and n6 oils generally confer protection via suppression of inflammation. This study investigated in wild-type mice if a PUFA diet enriched in docosahexanoic acid (DHA) restored blood-brain barrier integrity and attenuated parenchymal apo B abundance induced by chronic ingestion of SFA. Cerebrovascular leakage of apo B was quantitated utilising immunofluorescent staining. The plasma concentration of brain-derived S100β was measured as a marker of cerebrovascular inflammation. In mice fed SFA for 3 months, provision thereafter of a DHA-enriched diet exacerbated parenchymal apo B retention, concomitant with a significant increase in plasma cholesterol. In contrast, provision of a low-fat diet following chronic SFA feeding had no effect on SFA-induced parenchymal apo B. The findings suggest that in a heightened state of cerebrovascular inflammation, the provision of unsaturated fatty acids may be detrimental, possibly as a consequence of a greater susceptibility for oxidation.

Authors+Show Affiliations

Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, Western Australia 6845, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22121489

Citation

Pallebage-Gamarallage, Menuka M., et al. "A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced By Chronic Ingestion of Saturated Fats." International Journal of Vascular Medicine, vol. 2012, 2012, p. 647689.
Pallebage-Gamarallage MM, Lam V, Takechi R, et al. A diet enriched in docosahexanoic Acid exacerbates brain parenchymal extravasation of apo B lipoproteins induced by chronic ingestion of saturated fats. Int J Vasc Med. 2012;2012:647689.
Pallebage-Gamarallage, M. M., Lam, V., Takechi, R., Galloway, S., & Mamo, J. C. (2012). A diet enriched in docosahexanoic Acid exacerbates brain parenchymal extravasation of apo B lipoproteins induced by chronic ingestion of saturated fats. International Journal of Vascular Medicine, 2012, p. 647689. doi:10.1155/2012/647689.
Pallebage-Gamarallage MM, et al. A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced By Chronic Ingestion of Saturated Fats. Int J Vasc Med. 2012;2012:647689. PubMed PMID: 22121489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A diet enriched in docosahexanoic Acid exacerbates brain parenchymal extravasation of apo B lipoproteins induced by chronic ingestion of saturated fats. AU - Pallebage-Gamarallage,Menuka M, AU - Lam,Virginie, AU - Takechi,Ryusuke, AU - Galloway,Susan, AU - Mamo,John C L, Y1 - 2011/11/10/ PY - 2011/05/27/received PY - 2011/08/04/revised PY - 2011/08/26/accepted PY - 2011/11/29/entrez PY - 2011/11/29/pubmed PY - 2011/11/29/medline SP - 647689 EP - 647689 JF - International journal of vascular medicine JO - Int J Vasc Med VL - 2012 N2 - Chronic ingestion of saturated fatty acids (SFAs) was previously shown to compromise blood-brain barrier integrity, leading to brain parenchymal extravasation of apolipoprotein B (apo B) lipoproteins enriched in amyloid beta. In contrast, diets enriched in mono- or polyunsaturated (PUFA) oils had no detrimental effect. Rather, n3 and n6 oils generally confer protection via suppression of inflammation. This study investigated in wild-type mice if a PUFA diet enriched in docosahexanoic acid (DHA) restored blood-brain barrier integrity and attenuated parenchymal apo B abundance induced by chronic ingestion of SFA. Cerebrovascular leakage of apo B was quantitated utilising immunofluorescent staining. The plasma concentration of brain-derived S100β was measured as a marker of cerebrovascular inflammation. In mice fed SFA for 3 months, provision thereafter of a DHA-enriched diet exacerbated parenchymal apo B retention, concomitant with a significant increase in plasma cholesterol. In contrast, provision of a low-fat diet following chronic SFA feeding had no effect on SFA-induced parenchymal apo B. The findings suggest that in a heightened state of cerebrovascular inflammation, the provision of unsaturated fatty acids may be detrimental, possibly as a consequence of a greater susceptibility for oxidation. SN - 2090-2832 UR - https://www.unboundmedicine.com/medline/citation/22121489/A_diet_enriched_in_docosahexanoic_Acid_exacerbates_brain_parenchymal_extravasation_of_apo_B_lipoproteins_induced_by_chronic_ingestion_of_saturated_fats_ L2 - https://dx.doi.org/10.1155/2012/647689 DB - PRIME DP - Unbound Medicine ER -