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The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease.
Aging Cell 2012; 11(2):228-33AC

Abstract

The cholesteryl ester transfer protein (CETP) gene plays an essential role in regulating cholesterol homeostasis and is a candidate susceptibility gene for late-onset Alzheimer's disease (AD). Recent finding suggests that the CETP I405V polymorphism (rs5882) is associated with a slower rate of memory decline and a lower risk of incident dementia. Using data from two ongoing epidemiologic clinical-pathologic cohort studies of aging and dementia in the United States, the Religious Order Study and the Memory and Aging Project, we evaluated the association of the CETP I405V polymorphism (rs5882) with cognitive decline and risk of incident AD in more than 1300 participants of European ancestry. Our results suggest that the CETP I405V polymorphism was associated with a faster rather than a slower rate of decline in cognition over time, and an increased risk of incident AD. This finding is consistent with data showing that the CETP I405V is associated with increased neuritic plaque density at autopsy.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, Department of Neurological Science, Rush University Medical Center, Chicago, IL 60612, USA. lei_yu@rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22122979

Citation

Yu, Lei, et al. "The CETP I405V Polymorphism Is Associated With an Increased Risk of Alzheimer's Disease." Aging Cell, vol. 11, no. 2, 2012, pp. 228-33.
Yu L, Shulman JM, Chibnik L, et al. The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease. Aging Cell. 2012;11(2):228-33.
Yu, L., Shulman, J. M., Chibnik, L., Leurgans, S., Schneider, J. A., De Jager, P. L., & Bennett, D. A. (2012). The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease. Aging Cell, 11(2), pp. 228-33. doi:10.1111/j.1474-9726.2011.00777.x.
Yu L, et al. The CETP I405V Polymorphism Is Associated With an Increased Risk of Alzheimer's Disease. Aging Cell. 2012;11(2):228-33. PubMed PMID: 22122979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease. AU - Yu,Lei, AU - Shulman,Joshua M, AU - Chibnik,Lori, AU - Leurgans,Sue, AU - Schneider,Julie A, AU - De Jager,Philip L, AU - Bennett,David A, Y1 - 2011/12/29/ PY - 2011/11/30/entrez PY - 2011/11/30/pubmed PY - 2012/6/9/medline SP - 228 EP - 33 JF - Aging cell JO - Aging Cell VL - 11 IS - 2 N2 - The cholesteryl ester transfer protein (CETP) gene plays an essential role in regulating cholesterol homeostasis and is a candidate susceptibility gene for late-onset Alzheimer's disease (AD). Recent finding suggests that the CETP I405V polymorphism (rs5882) is associated with a slower rate of memory decline and a lower risk of incident dementia. Using data from two ongoing epidemiologic clinical-pathologic cohort studies of aging and dementia in the United States, the Religious Order Study and the Memory and Aging Project, we evaluated the association of the CETP I405V polymorphism (rs5882) with cognitive decline and risk of incident AD in more than 1300 participants of European ancestry. Our results suggest that the CETP I405V polymorphism was associated with a faster rather than a slower rate of decline in cognition over time, and an increased risk of incident AD. This finding is consistent with data showing that the CETP I405V is associated with increased neuritic plaque density at autopsy. SN - 1474-9726 UR - https://www.unboundmedicine.com/medline/citation/22122979/The_CETP_I405V_polymorphism_is_associated_with_an_increased_risk_of_Alzheimer's_disease_ L2 - https://doi.org/10.1111/j.1474-9726.2011.00777.x DB - PRIME DP - Unbound Medicine ER -