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Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation.
J Ethnopharmacol. 2012 Jan 31; 139(2):381-7.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Persicae Semen (Taoren) and Carthami Flos (Honghua) used in pair which is named as Taoren-Honghua (TH) herb pair has been used in traditional Chinese medicine (TCM) for promoting blood circulation to dissipate blood stasis for many years in China.

AIM OF THE STUDY

This paper investigated the effects of TH and its main components amygdalin and hydroxysafflor yellow A (HSYA) on hemorheological disorders of blood stasis in rats.

MATERIALS AND METHODS

Rats were randomly divided into seven groups (control group, model group, TH group, amygdalin group, HSYA group, amygdalin+HSYA group, and aspirin group) with eight animals in each, whose gender was equally distributed throughout groups. All treatments were performed by gavage and administered seven times with an interval of 12h. After the fifth administration, the model rats except those in control group with blood stasis were established by being placed in ice-cold water during the interval between two injections of adrenaline hydrochloride (Adr); and blood samples were collected 30min after the last administration on the following day.

RESULTS

TH could significantly decrease whole blood viscosity (WBV), plasma viscosity (PV) and packed cell volume (PCV). It also significantly prolonged thrombin time (TT) and thromboplastin time (APTT), increased prothrombin time (PT) and lowered fibrinogen content (FIB). HSYA which significantly decreased WBV and PV had no effect on plasma coagulation parameters. Amygdalin could significantly decrease PV, prolong APTT and decrease FIB, showing few effects on WBV. TH and its main components amygdalin and HSYA could significantly reduce platelet aggregation and protect vascular endothelial cells. Based on the above results, amygdalin and HSYA were responsible for the main curative effects of TH and usually had synergetic effects, such as decreasing PV and platelet aggregation percentage.

CONCLUSIONS

The study may provide scientific information to further understanding of the mechanism(s) of TH and its main components in activating blood circulation to dissipate blood. It may also create valuable insight into the possible effects and utilization of TH and its components as a feasible alternative therapeutic agent for patients with hemorheological disorders.

Authors+Show Affiliations

Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22123200

Citation

Liu, Li, et al. "Taoren-Honghua Herb Pair and Its Main Components Promoting Blood Circulation Through Influencing On Hemorheology, Plasma Coagulation and Platelet Aggregation." Journal of Ethnopharmacology, vol. 139, no. 2, 2012, pp. 381-7.
Liu L, Duan JA, Tang Y, et al. Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation. J Ethnopharmacol. 2012;139(2):381-7.
Liu, L., Duan, J. A., Tang, Y., Guo, J., Yang, N., Ma, H., & Shi, X. (2012). Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation. Journal of Ethnopharmacology, 139(2), 381-7. https://doi.org/10.1016/j.jep.2011.11.016
Liu L, et al. Taoren-Honghua Herb Pair and Its Main Components Promoting Blood Circulation Through Influencing On Hemorheology, Plasma Coagulation and Platelet Aggregation. J Ethnopharmacol. 2012 Jan 31;139(2):381-7. PubMed PMID: 22123200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation. AU - Liu,Li, AU - Duan,Jin-ao, AU - Tang,Yuping, AU - Guo,Jianming, AU - Yang,Nianyun, AU - Ma,Hongyue, AU - Shi,Xuqin, Y1 - 2011/11/20/ PY - 2011/05/08/received PY - 2011/10/21/revised PY - 2011/11/12/accepted PY - 2011/11/30/entrez PY - 2011/11/30/pubmed PY - 2012/5/9/medline SP - 381 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 139 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Persicae Semen (Taoren) and Carthami Flos (Honghua) used in pair which is named as Taoren-Honghua (TH) herb pair has been used in traditional Chinese medicine (TCM) for promoting blood circulation to dissipate blood stasis for many years in China. AIM OF THE STUDY: This paper investigated the effects of TH and its main components amygdalin and hydroxysafflor yellow A (HSYA) on hemorheological disorders of blood stasis in rats. MATERIALS AND METHODS: Rats were randomly divided into seven groups (control group, model group, TH group, amygdalin group, HSYA group, amygdalin+HSYA group, and aspirin group) with eight animals in each, whose gender was equally distributed throughout groups. All treatments were performed by gavage and administered seven times with an interval of 12h. After the fifth administration, the model rats except those in control group with blood stasis were established by being placed in ice-cold water during the interval between two injections of adrenaline hydrochloride (Adr); and blood samples were collected 30min after the last administration on the following day. RESULTS: TH could significantly decrease whole blood viscosity (WBV), plasma viscosity (PV) and packed cell volume (PCV). It also significantly prolonged thrombin time (TT) and thromboplastin time (APTT), increased prothrombin time (PT) and lowered fibrinogen content (FIB). HSYA which significantly decreased WBV and PV had no effect on plasma coagulation parameters. Amygdalin could significantly decrease PV, prolong APTT and decrease FIB, showing few effects on WBV. TH and its main components amygdalin and HSYA could significantly reduce platelet aggregation and protect vascular endothelial cells. Based on the above results, amygdalin and HSYA were responsible for the main curative effects of TH and usually had synergetic effects, such as decreasing PV and platelet aggregation percentage. CONCLUSIONS: The study may provide scientific information to further understanding of the mechanism(s) of TH and its main components in activating blood circulation to dissipate blood. It may also create valuable insight into the possible effects and utilization of TH and its components as a feasible alternative therapeutic agent for patients with hemorheological disorders. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22123200/Taoren_Honghua_herb_pair_and_its_main_components_promoting_blood_circulation_through_influencing_on_hemorheology_plasma_coagulation_and_platelet_aggregation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00823-3 DB - PRIME DP - Unbound Medicine ER -