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Folate recommendations for pregnancy, lactation, and infancy.
Ann Nutr Metab. 2011; 59(1):32-7.AN

Abstract

An adequate intake of folate during pregnancy, lactation, and infancy is essential for maternal and child health and normal growth. Higher folate requirements during pregnancy and lactation are difficult to meet by increased intake of folate-rich food products only. Supplementation with folic acid is recommended not only to meet the higher requirements but also to prevent adverse pregnancy outcomes such as neural tube defects (NTDs). In countries that have implemented food fortification with folic acid, the folate intake has raised but does not yet meet the recommended amount for NTD risk reduction. Women's awareness of the need to supplement with folic acid prior to conception shall be raised in all countries. It is under debate whether a high folic acid intake might have metabolic and functional effects in utero and for the infant. Research is needed to investigate potential alternative folate forms for food fortification programs and to test their efficacy in risk reduction of adverse pregnancy outcomes. Breast-fed infants most likely receive sufficient folate. While the folate level of human milk is simulated in infant formula, data are lacking on the bioavailability and effect of folic acid in infants and on whether a tolerable upper intake level should be defined.

Authors+Show Affiliations

Food, Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada. yvonne.lamers@ubc.ca

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22123635

Citation

Lamers, Yvonne. "Folate Recommendations for Pregnancy, Lactation, and Infancy." Annals of Nutrition & Metabolism, vol. 59, no. 1, 2011, pp. 32-7.
Lamers Y. Folate recommendations for pregnancy, lactation, and infancy. Ann Nutr Metab. 2011;59(1):32-7.
Lamers, Y. (2011). Folate recommendations for pregnancy, lactation, and infancy. Annals of Nutrition & Metabolism, 59(1), 32-7. https://doi.org/10.1159/000332073
Lamers Y. Folate Recommendations for Pregnancy, Lactation, and Infancy. Ann Nutr Metab. 2011;59(1):32-7. PubMed PMID: 22123635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate recommendations for pregnancy, lactation, and infancy. A1 - Lamers,Yvonne, Y1 - 2011/11/25/ PY - 2011/11/30/entrez PY - 2011/11/30/pubmed PY - 2012/3/23/medline SP - 32 EP - 7 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 59 IS - 1 N2 - An adequate intake of folate during pregnancy, lactation, and infancy is essential for maternal and child health and normal growth. Higher folate requirements during pregnancy and lactation are difficult to meet by increased intake of folate-rich food products only. Supplementation with folic acid is recommended not only to meet the higher requirements but also to prevent adverse pregnancy outcomes such as neural tube defects (NTDs). In countries that have implemented food fortification with folic acid, the folate intake has raised but does not yet meet the recommended amount for NTD risk reduction. Women's awareness of the need to supplement with folic acid prior to conception shall be raised in all countries. It is under debate whether a high folic acid intake might have metabolic and functional effects in utero and for the infant. Research is needed to investigate potential alternative folate forms for food fortification programs and to test their efficacy in risk reduction of adverse pregnancy outcomes. Breast-fed infants most likely receive sufficient folate. While the folate level of human milk is simulated in infant formula, data are lacking on the bioavailability and effect of folic acid in infants and on whether a tolerable upper intake level should be defined. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/22123635/Folate_recommendations_for_pregnancy_lactation_and_infancy_ L2 - https://www.karger.com?DOI=10.1159/000332073 DB - PRIME DP - Unbound Medicine ER -