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Folic acid and other potential measures in the prevention of neural tube defects.
Ann Nutr Metab. 2011; 59(1):41-5.AN

Abstract

Neural tube defects (NTD) are common congenital malformations leading to severe disability or even death. The causes of NTD are multifactorial, including genetic predisposition, nutritional and environmental risk factors, and other maternal conditions. Some countries have introduced mandatory or at least voluntary folic acid fortification as an effective measure to reduce NTD, whereas others support periconceptional supplementation of women of childbearing age. Countries with mandatory fortification achieved a significant increase in folate intake and a significant decline in the prevalence of NTD. This was also true for supplementation trials. However, the magnitude of the decline depends on the initial NTD rate. This review clearly shows that not all cases of NTD can be prevented by increasing the folate intake. Other relevant causes of NTD, which are largely disregarded, have also to be taken into account in research and consultation to reduce the risk and economic burden of NTD.

Authors+Show Affiliations

Institute of Nutrition, Consumption and Health, University of Paderborn, Paderborn, Germany. helmut.heseker@upb.de

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22123637

Citation

Heseker, Helmut. "Folic Acid and Other Potential Measures in the Prevention of Neural Tube Defects." Annals of Nutrition & Metabolism, vol. 59, no. 1, 2011, pp. 41-5.
Heseker H. Folic acid and other potential measures in the prevention of neural tube defects. Ann Nutr Metab. 2011;59(1):41-5.
Heseker, H. (2011). Folic acid and other potential measures in the prevention of neural tube defects. Annals of Nutrition & Metabolism, 59(1), 41-5. https://doi.org/10.1159/000332126
Heseker H. Folic Acid and Other Potential Measures in the Prevention of Neural Tube Defects. Ann Nutr Metab. 2011;59(1):41-5. PubMed PMID: 22123637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid and other potential measures in the prevention of neural tube defects. A1 - Heseker,Helmut, Y1 - 2011/11/25/ PY - 2011/11/30/entrez PY - 2011/11/30/pubmed PY - 2012/3/23/medline SP - 41 EP - 5 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 59 IS - 1 N2 - Neural tube defects (NTD) are common congenital malformations leading to severe disability or even death. The causes of NTD are multifactorial, including genetic predisposition, nutritional and environmental risk factors, and other maternal conditions. Some countries have introduced mandatory or at least voluntary folic acid fortification as an effective measure to reduce NTD, whereas others support periconceptional supplementation of women of childbearing age. Countries with mandatory fortification achieved a significant increase in folate intake and a significant decline in the prevalence of NTD. This was also true for supplementation trials. However, the magnitude of the decline depends on the initial NTD rate. This review clearly shows that not all cases of NTD can be prevented by increasing the folate intake. Other relevant causes of NTD, which are largely disregarded, have also to be taken into account in research and consultation to reduce the risk and economic burden of NTD. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/22123637/Folic_acid_and_other_potential_measures_in_the_prevention_of_neural_tube_defects_ L2 - https://www.karger.com?DOI=10.1159/000332126 DB - PRIME DP - Unbound Medicine ER -