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Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility.
Rev Bras Reumatol 2011; 51(6):594-602RB

Abstract

OBJECTIVES

This study aimed to investigate the genetic influence of the T102C polymorphism of the 2A serotonin receptor gene (HTR2A) and its interaction with environmental aspects, such as exposure to noise, traffic, climate, and opportunities to acquire new information, physical protection, and security, among others, as possible risk factors for developing fibromyalgia syndrome (FMS).

METHODS

Forty-one FMS patients and 49 controls were evaluated. Environmental factors were evaluated by application of the V domain of the WHOQOL-100 questionnaire. Patients were asked that their answers represented only the periods preceding the onset of symptoms. The T102C variant of the HTR2A gene was determined through PCR/RFLP.

RESULTS

Among patients, the frequency of carriers of the 102C allele was higher than in controls (76.5% vs. 50%; P = 0.028). The scores of the V domain were lower in patients than in controls, indicating a worst perception of the environmental quality by patients (P < 0.001). The factor "lack of opportunities for acquiring new information and skills" increased the chance of developing FMS by almost 14-fold (P = 0.009). The factor "low quality of social care and health" together with the presence of the 102C allele also increased this chance by more than 90-fold (P = 0.005). However, carriers of the same allele who have high quality social care and health are not at a higher risk to develop FMS.

CONCLUSION

These data suggest that these factors may predispose to FMS, especially in carriers of the 102C allele. However, studies with larger samples are required to confirm this hypothesis.

Authors+Show Affiliations

Universidade Federal de Ciências da Saúde de Porto Alegre.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng por

PubMed ID

22124593

Citation

Mergener, Michelle, et al. "Influence of the Interaction Between Environmental Quality and T102C SNP in the HTR2A Gene On Fibromyalgia Susceptibility." Revista Brasileira De Reumatologia, vol. 51, no. 6, 2011, pp. 594-602.
Mergener M, Becker RM, dos Santos AF, et al. Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility. Rev Bras Reumatol. 2011;51(6):594-602.
Mergener, M., Becker, R. M., dos Santos, A. F., dos Santos, G. A., & de Andrade, F. M. (2011). Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility. Revista Brasileira De Reumatologia, 51(6), pp. 594-602.
Mergener M, et al. Influence of the Interaction Between Environmental Quality and T102C SNP in the HTR2A Gene On Fibromyalgia Susceptibility. Rev Bras Reumatol. 2011;51(6):594-602. PubMed PMID: 22124593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility. AU - Mergener,Michelle, AU - Becker,Roze Mary Ribas, AU - dos Santos,Adriana Freitag, AU - dos Santos,Geraldine Alves, AU - de Andrade,Fabiana Michelsen, PY - 2011/04/15/received PY - 2011/08/30/accepted PY - 2011/11/30/entrez PY - 2011/11/30/pubmed PY - 2012/4/14/medline SP - 594 EP - 602 JF - Revista brasileira de reumatologia JO - Rev Bras Reumatol VL - 51 IS - 6 N2 - OBJECTIVES: This study aimed to investigate the genetic influence of the T102C polymorphism of the 2A serotonin receptor gene (HTR2A) and its interaction with environmental aspects, such as exposure to noise, traffic, climate, and opportunities to acquire new information, physical protection, and security, among others, as possible risk factors for developing fibromyalgia syndrome (FMS). METHODS: Forty-one FMS patients and 49 controls were evaluated. Environmental factors were evaluated by application of the V domain of the WHOQOL-100 questionnaire. Patients were asked that their answers represented only the periods preceding the onset of symptoms. The T102C variant of the HTR2A gene was determined through PCR/RFLP. RESULTS: Among patients, the frequency of carriers of the 102C allele was higher than in controls (76.5% vs. 50%; P = 0.028). The scores of the V domain were lower in patients than in controls, indicating a worst perception of the environmental quality by patients (P < 0.001). The factor "lack of opportunities for acquiring new information and skills" increased the chance of developing FMS by almost 14-fold (P = 0.009). The factor "low quality of social care and health" together with the presence of the 102C allele also increased this chance by more than 90-fold (P = 0.005). However, carriers of the same allele who have high quality social care and health are not at a higher risk to develop FMS. CONCLUSION: These data suggest that these factors may predispose to FMS, especially in carriers of the 102C allele. However, studies with larger samples are required to confirm this hypothesis. SN - 1809-4570 UR - https://www.unboundmedicine.com/medline/citation/22124593/Influence_of_the_interaction_between_environmental_quality_and_T102C_SNP_in_the_HTR2A_gene_on_fibromyalgia_susceptibility_ L2 - http://www.diseaseinfosearch.org/result/2854 DB - PRIME DP - Unbound Medicine ER -