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Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide.
Indian J Exp Biol 2011; 49(11):805-16IJ

Abstract

Health benefits of garlic and other Allium vegetables (e.g., onions), such as lipid lowering and anticancer effects, are credited to metabolic byproducts, including diallyl trisulfide (DATS). Evidence for anticancer effects of garlic derives from both population-based case-control studies, and clinical and laboratory investigations using purified garlic constituents such as DATS. Studies have shown that DATS can offer protection against chemically-induced neoplasia as well as oncogene-driven spontaneous cancer development in experimental rodents. Mechanisms underlying cancer chemopreventive effects of DATS are not completely understood, but known pharmacological responses to this natural product include alteration in carcinogen-metabolizing enzymes, cell cycle arrest, induction of apoptotic cell death, suppression of oncogenic signal transduction pathways, and inhibition of neoangiogenesis. This article reviews mechanisms and targets of cancer chemoprevention by DATS.

Authors+Show Affiliations

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22126011

Citation

Antony, Marie Lue, and Shivendra V. Singh. "Molecular Mechanisms and Targets of Cancer Chemoprevention By Garlic-derived Bioactive Compound Diallyl Trisulfide." Indian Journal of Experimental Biology, vol. 49, no. 11, 2011, pp. 805-16.
Antony ML, Singh SV. Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide. Indian J Exp Biol. 2011;49(11):805-16.
Antony, M. L., & Singh, S. V. (2011). Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide. Indian Journal of Experimental Biology, 49(11), pp. 805-16.
Antony ML, Singh SV. Molecular Mechanisms and Targets of Cancer Chemoprevention By Garlic-derived Bioactive Compound Diallyl Trisulfide. Indian J Exp Biol. 2011;49(11):805-16. PubMed PMID: 22126011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide. AU - Antony,Marie Lue, AU - Singh,Shivendra V, PY - 2011/12/1/entrez PY - 2011/12/1/pubmed PY - 2011/12/22/medline SP - 805 EP - 16 JF - Indian journal of experimental biology JO - Indian J. Exp. Biol. VL - 49 IS - 11 N2 - Health benefits of garlic and other Allium vegetables (e.g., onions), such as lipid lowering and anticancer effects, are credited to metabolic byproducts, including diallyl trisulfide (DATS). Evidence for anticancer effects of garlic derives from both population-based case-control studies, and clinical and laboratory investigations using purified garlic constituents such as DATS. Studies have shown that DATS can offer protection against chemically-induced neoplasia as well as oncogene-driven spontaneous cancer development in experimental rodents. Mechanisms underlying cancer chemopreventive effects of DATS are not completely understood, but known pharmacological responses to this natural product include alteration in carcinogen-metabolizing enzymes, cell cycle arrest, induction of apoptotic cell death, suppression of oncogenic signal transduction pathways, and inhibition of neoangiogenesis. This article reviews mechanisms and targets of cancer chemoprevention by DATS. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/22126011/Molecular_mechanisms_and_targets_of_cancer_chemoprevention_by_garlic_derived_bioactive_compound_diallyl_trisulfide_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22126011/ DB - PRIME DP - Unbound Medicine ER -