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Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide.

Abstract

Health benefits of garlic and other Allium vegetables (e.g., onions), such as lipid lowering and anticancer effects, are credited to metabolic byproducts, including diallyl trisulfide (DATS). Evidence for anticancer effects of garlic derives from both population-based case-control studies, and clinical and laboratory investigations using purified garlic constituents such as DATS. Studies have shown that DATS can offer protection against chemically-induced neoplasia as well as oncogene-driven spontaneous cancer development in experimental rodents. Mechanisms underlying cancer chemopreventive effects of DATS are not completely understood, but known pharmacological responses to this natural product include alteration in carcinogen-metabolizing enzymes, cell cycle arrest, induction of apoptotic cell death, suppression of oncogenic signal transduction pathways, and inhibition of neoangiogenesis. This article reviews mechanisms and targets of cancer chemoprevention by DATS.

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  • Authors+Show Affiliations

    ,

    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

    Source

    MeSH

    Allyl Compounds
    Animals
    Anticarcinogenic Agents
    Apoptosis
    Cell Cycle Checkpoints
    Cell Proliferation
    Chemoprevention
    Garlic
    Humans
    Metabolic Networks and Pathways
    Mice
    Neoplasms
    Sulfides

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    22126011

    Citation

    Antony, Marie Lue, and Shivendra V. Singh. "Molecular Mechanisms and Targets of Cancer Chemoprevention By Garlic-derived Bioactive Compound Diallyl Trisulfide." Indian Journal of Experimental Biology, vol. 49, no. 11, 2011, pp. 805-16.
    Antony ML, Singh SV. Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide. Indian J Exp Biol. 2011;49(11):805-16.
    Antony, M. L., & Singh, S. V. (2011). Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide. Indian Journal of Experimental Biology, 49(11), pp. 805-16.
    Antony ML, Singh SV. Molecular Mechanisms and Targets of Cancer Chemoprevention By Garlic-derived Bioactive Compound Diallyl Trisulfide. Indian J Exp Biol. 2011;49(11):805-16. PubMed PMID: 22126011.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide. AU - Antony,Marie Lue, AU - Singh,Shivendra V, PY - 2011/12/1/entrez PY - 2011/12/1/pubmed PY - 2011/12/22/medline SP - 805 EP - 16 JF - Indian journal of experimental biology JO - Indian J. Exp. Biol. VL - 49 IS - 11 N2 - Health benefits of garlic and other Allium vegetables (e.g., onions), such as lipid lowering and anticancer effects, are credited to metabolic byproducts, including diallyl trisulfide (DATS). Evidence for anticancer effects of garlic derives from both population-based case-control studies, and clinical and laboratory investigations using purified garlic constituents such as DATS. Studies have shown that DATS can offer protection against chemically-induced neoplasia as well as oncogene-driven spontaneous cancer development in experimental rodents. Mechanisms underlying cancer chemopreventive effects of DATS are not completely understood, but known pharmacological responses to this natural product include alteration in carcinogen-metabolizing enzymes, cell cycle arrest, induction of apoptotic cell death, suppression of oncogenic signal transduction pathways, and inhibition of neoangiogenesis. This article reviews mechanisms and targets of cancer chemoprevention by DATS. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/22126011/Molecular_mechanisms_and_targets_of_cancer_chemoprevention_by_garlic_derived_bioactive_compound_diallyl_trisulfide_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22126011/ DB - PRIME DP - Unbound Medicine ER -