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Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis.
J Environ Pathol Toxicol Oncol. 2011; 30(3):199-211.JE

Abstract

Oral cancer accounts for 40%-50% of all cancers in India. Tobacco and alcohol are the major etiological factors contributing to its pathogenesis. The aim of the present study was to explore the key mechanism behind the inhibitory effects of rosmarinic acid against 7,12-dimethylbenz(a)anthracene (DMBA)-induced oral carcinogenesis by evaluating the status of biochemical markers (lipid peroxidation, antioxidants, and detoxification enzymes) and immunoexpression patterns of p53 and bcl-2 proteins. Oral tumors were developed by painting the buccal pouches of golden Syrian hamsters with 0.5% DMBA in liquid paraffin 3 times a week for 14 weeks. We noticed 100% tumor formation in hamsters treated with DMBA alone, and the tumors were histopathologically confirmed as well-differentiated squamous cell carcinoma. Oral administration of rosmarinic acid (100 mg/kg body wt) to DMBA-treated hamsters completely prevented the tumor formation. In addition, rosmarinic acid significantly returned the status of biochemical and molecular markers to near normal range in DMBA-treated hamsters. The results of the present study suggest that rosmarinic acid suppresses oral carcinogenesis by stimulating the activities of detoxification enzymes, improves the status of lipid peroxidation and antioxidants, and downregulates the expression of p53 and bcl-2 during DMBA-induced oral carcinogenesis.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22126613

Citation

Anusuya, Chezhiyan, and Shanmugam Manoharan. "Antitumor Initiating Potential of Rosmarinic Acid in 7,12-dimethylbenz(a)anthracene-induced Hamster Buccal Pouch Carcinogenesis." Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 30, no. 3, 2011, pp. 199-211.
Anusuya C, Manoharan S. Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis. J Environ Pathol Toxicol Oncol. 2011;30(3):199-211.
Anusuya, C., & Manoharan, S. (2011). Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 30(3), 199-211.
Anusuya C, Manoharan S. Antitumor Initiating Potential of Rosmarinic Acid in 7,12-dimethylbenz(a)anthracene-induced Hamster Buccal Pouch Carcinogenesis. J Environ Pathol Toxicol Oncol. 2011;30(3):199-211. PubMed PMID: 22126613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis. AU - Anusuya,Chezhiyan, AU - Manoharan,Shanmugam, PY - 2011/12/1/entrez PY - 2011/12/1/pubmed PY - 2012/2/9/medline SP - 199 EP - 211 JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer JO - J Environ Pathol Toxicol Oncol VL - 30 IS - 3 N2 - Oral cancer accounts for 40%-50% of all cancers in India. Tobacco and alcohol are the major etiological factors contributing to its pathogenesis. The aim of the present study was to explore the key mechanism behind the inhibitory effects of rosmarinic acid against 7,12-dimethylbenz(a)anthracene (DMBA)-induced oral carcinogenesis by evaluating the status of biochemical markers (lipid peroxidation, antioxidants, and detoxification enzymes) and immunoexpression patterns of p53 and bcl-2 proteins. Oral tumors were developed by painting the buccal pouches of golden Syrian hamsters with 0.5% DMBA in liquid paraffin 3 times a week for 14 weeks. We noticed 100% tumor formation in hamsters treated with DMBA alone, and the tumors were histopathologically confirmed as well-differentiated squamous cell carcinoma. Oral administration of rosmarinic acid (100 mg/kg body wt) to DMBA-treated hamsters completely prevented the tumor formation. In addition, rosmarinic acid significantly returned the status of biochemical and molecular markers to near normal range in DMBA-treated hamsters. The results of the present study suggest that rosmarinic acid suppresses oral carcinogenesis by stimulating the activities of detoxification enzymes, improves the status of lipid peroxidation and antioxidants, and downregulates the expression of p53 and bcl-2 during DMBA-induced oral carcinogenesis. SN - 2162-6537 UR - https://www.unboundmedicine.com/medline/citation/22126613/Antitumor_initiating_potential_of_rosmarinic_acid_in_712_dimethylbenz_a_anthracene_induced_hamster_buccal_pouch_carcinogenesis_ L2 - http://www.begellhouse.com/journals/0ff459a57a4c08d0,28d5b25a1eb31fda,0528c54d4896a9c6.html DB - PRIME DP - Unbound Medicine ER -