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Early infection with M. leprae and antibodies to phenolic glycolipid-I in the nine-banded armadillo.
Indian J Lepr. 1990 Apr-Jun; 62(2):193-201.IJ

Abstract

Nine-banded armadillos were intravenously infected with 10(9) M. leprae. IgM antibodies to PGL-I were evaluated three times during the six months before and every two months after the infection. A thorough autopsy examination was done on animals that died or were sacrificed at intervals of 3, 4, 6, 12, 15 and 18 months after the infection. Three animals which had acquired the infection in the wild and one experimentally infected animal showed significant increases in antibody levels corresponding to their high bacterial load. In the other five experimentally infected animals, M. leprae infection was established in the cells of the reticulo endothelial system (RES) long before the IgM antibody levels to PGL-I became positive. It is possible that in human leprosy also M. leprae may enter and multiply in the RES initiating antibody production during the incubation period before clinical disease with neuritis becomes manifest.

Authors+Show Affiliations

Pathology Research Department, Gillis W. Long Hansen's Disease Center, Carville, LA 70721.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2212734

Citation

Job, C K., et al. "Early Infection With M. Leprae and Antibodies to Phenolic glycolipid-I in the Nine-banded Armadillo." Indian Journal of Leprosy, vol. 62, no. 2, 1990, pp. 193-201.
Job CK, Drain V, Truman RW, et al. Early infection with M. leprae and antibodies to phenolic glycolipid-I in the nine-banded armadillo. Indian J Lepr. 1990;62(2):193-201.
Job, C. K., Drain, V., Truman, R. W., Sanchez, R. M., & Hastings, R. C. (1990). Early infection with M. leprae and antibodies to phenolic glycolipid-I in the nine-banded armadillo. Indian Journal of Leprosy, 62(2), 193-201.
Job CK, et al. Early Infection With M. Leprae and Antibodies to Phenolic glycolipid-I in the Nine-banded Armadillo. Indian J Lepr. 1990 Apr-Jun;62(2):193-201. PubMed PMID: 2212734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early infection with M. leprae and antibodies to phenolic glycolipid-I in the nine-banded armadillo. AU - Job,C K, AU - Drain,V, AU - Truman,R W, AU - Sanchez,R M, AU - Hastings,R C, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 193 EP - 201 JF - Indian journal of leprosy JO - Indian J Lepr VL - 62 IS - 2 N2 - Nine-banded armadillos were intravenously infected with 10(9) M. leprae. IgM antibodies to PGL-I were evaluated three times during the six months before and every two months after the infection. A thorough autopsy examination was done on animals that died or were sacrificed at intervals of 3, 4, 6, 12, 15 and 18 months after the infection. Three animals which had acquired the infection in the wild and one experimentally infected animal showed significant increases in antibody levels corresponding to their high bacterial load. In the other five experimentally infected animals, M. leprae infection was established in the cells of the reticulo endothelial system (RES) long before the IgM antibody levels to PGL-I became positive. It is possible that in human leprosy also M. leprae may enter and multiply in the RES initiating antibody production during the incubation period before clinical disease with neuritis becomes manifest. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/2212734/Early_infection_with_M__leprae_and_antibodies_to_phenolic_glycolipid_I_in_the_nine_banded_armadillo_ DB - PRIME DP - Unbound Medicine ER -