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Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet.
Food Funct. 2012 Feb; 3(2):170-7.FF

Abstract

Although green tea extract has been reported to suppress hyperlipidemia, it is unclear how tea extracts prepared from green, oolong, black and pu-erh teas modulate fatty acid synthase expression in rats fed on a high-fructose diet. In this animal study, we evaluated the hypolipidemic and hypoleptinemia effect of these four different tea leaves fed to male Wistar rats for 12 weeks. The results showed that a fructose-rich diet significantly elevated serum triacylglycerols, cholesterol, insulin, and leptin concentrations, as compared with those in the control group. Interestingly, consuming tea leaves for 12 weeks almost normalized the serum triacylglycerols concentrations. Again, rats fed with fructose/green tea and fructose/pu-erh tea showed the greatest reduction in serum TG, cholesterol, insulin and leptin levels. In contrast, serum cholesterol and insulin concentrations of the fructose/oolong tea-fed rats did not normalize. The relative epididymal adipose tissue weight was lower in all rats supplemented with tea leaves than those fed with fructose alone. There was molecular evidence of improved lipid homeostasis according to fatty acid synthase (FAS) protein expression. Furthermore, supplementation of green, black, and pu-erh tea leaves significantly decreased hepatic FAS mRNA and protein levels, and increased AMPK phosphorylation, compared with those of rats fed with fructose only. These findings suggest that the intake of green, black, and pu-erh tea leaves ameliorated the fructose-induced hyperlipidemia and hyperleptinemia state in part through the suppression of FAS protein levels and increased AMPK phosphorylation.

Authors+Show Affiliations

Department of Applied Science, National Hsinchu University of Education, No.521 Nanda Rd., Hsinchu, Taiwan. jane@mail.nhcue.edu.twNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22127373

Citation

Huang, Hsiu-Chen, and Jen-Kun Lin. "Pu-erh Tea, Green Tea, and Black Tea Suppresses Hyperlipidemia, Hyperleptinemia and Fatty Acid Synthase Through Activating AMPK in Rats Fed a High-fructose Diet." Food & Function, vol. 3, no. 2, 2012, pp. 170-7.
Huang HC, Lin JK. Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet. Food Funct. 2012;3(2):170-7.
Huang, H. C., & Lin, J. K. (2012). Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet. Food & Function, 3(2), 170-7. https://doi.org/10.1039/c1fo10157a
Huang HC, Lin JK. Pu-erh Tea, Green Tea, and Black Tea Suppresses Hyperlipidemia, Hyperleptinemia and Fatty Acid Synthase Through Activating AMPK in Rats Fed a High-fructose Diet. Food Funct. 2012;3(2):170-7. PubMed PMID: 22127373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet. AU - Huang,Hsiu-Chen, AU - Lin,Jen-Kun, Y1 - 2011/11/30/ PY - 2011/12/1/entrez PY - 2011/12/1/pubmed PY - 2012/5/23/medline SP - 170 EP - 7 JF - Food & function JO - Food Funct VL - 3 IS - 2 N2 - Although green tea extract has been reported to suppress hyperlipidemia, it is unclear how tea extracts prepared from green, oolong, black and pu-erh teas modulate fatty acid synthase expression in rats fed on a high-fructose diet. In this animal study, we evaluated the hypolipidemic and hypoleptinemia effect of these four different tea leaves fed to male Wistar rats for 12 weeks. The results showed that a fructose-rich diet significantly elevated serum triacylglycerols, cholesterol, insulin, and leptin concentrations, as compared with those in the control group. Interestingly, consuming tea leaves for 12 weeks almost normalized the serum triacylglycerols concentrations. Again, rats fed with fructose/green tea and fructose/pu-erh tea showed the greatest reduction in serum TG, cholesterol, insulin and leptin levels. In contrast, serum cholesterol and insulin concentrations of the fructose/oolong tea-fed rats did not normalize. The relative epididymal adipose tissue weight was lower in all rats supplemented with tea leaves than those fed with fructose alone. There was molecular evidence of improved lipid homeostasis according to fatty acid synthase (FAS) protein expression. Furthermore, supplementation of green, black, and pu-erh tea leaves significantly decreased hepatic FAS mRNA and protein levels, and increased AMPK phosphorylation, compared with those of rats fed with fructose only. These findings suggest that the intake of green, black, and pu-erh tea leaves ameliorated the fructose-induced hyperlipidemia and hyperleptinemia state in part through the suppression of FAS protein levels and increased AMPK phosphorylation. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/22127373/Pu_erh_tea_green_tea_and_black_tea_suppresses_hyperlipidemia_hyperleptinemia_and_fatty_acid_synthase_through_activating_AMPK_in_rats_fed_a_high_fructose_diet_ L2 - https://doi.org/10.1039/c1fo10157a DB - PRIME DP - Unbound Medicine ER -