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Safety and side effects of cannabidiol, a Cannabis sativa constituent.
Curr Drug Saf 2011; 6(4):237-49CD

Abstract

Cannabidiol (CBD), a major nonpsychotropic constituent of Cannabis, has multiple pharmacological actions, including anxiolytic, antipsychotic, antiemetic and anti-inflammatory properties. However, little is known about its safety and side effect profile in animals and humans. This review describes in vivo and in vitro reports of CBD administration across a wide range of concentrations, based on reports retrieved from Web of Science, Scielo and Medline. The keywords searched were "cannabinoids", "cannabidiol" and "side effects". Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature), does not affect gastrointestinal transit and does not alter psychomotor or psychological functions. Also, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Conversely, some studies reported that this cannabinoid can induce some side effects, including inhibition of hepatic drug metabolism, alterations of in vitro cell viability, decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters. Based on recent advances in cannabinoid administration in humans, controlled CBD may be safe in humans and animals. However, further studies are needed to clarify these reported in vitro and in vivo side effects.

Authors+Show Affiliations

Department of Clinical, Toxicological and Food Sciences Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, SP, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22129319

Citation

Bergamaschi, Mateus Machado, et al. "Safety and Side Effects of Cannabidiol, a Cannabis Sativa Constituent." Current Drug Safety, vol. 6, no. 4, 2011, pp. 237-49.
Bergamaschi MM, Queiroz RH, Zuardi AW, et al. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf. 2011;6(4):237-49.
Bergamaschi, M. M., Queiroz, R. H., Zuardi, A. W., & Crippa, J. A. (2011). Safety and side effects of cannabidiol, a Cannabis sativa constituent. Current Drug Safety, 6(4), pp. 237-49.
Bergamaschi MM, et al. Safety and Side Effects of Cannabidiol, a Cannabis Sativa Constituent. Curr Drug Saf. 2011 Sep 1;6(4):237-49. PubMed PMID: 22129319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and side effects of cannabidiol, a Cannabis sativa constituent. AU - Bergamaschi,Mateus Machado, AU - Queiroz,Regina Helena Costa, AU - Zuardi,Antonio Waldo, AU - Crippa,José Alexandre S, PY - 2011/08/08/received PY - 2011/10/10/revised PY - 2011/10/10/accepted PY - 2011/12/2/entrez PY - 2011/12/2/pubmed PY - 2012/8/21/medline SP - 237 EP - 49 JF - Current drug safety JO - Curr Drug Saf VL - 6 IS - 4 N2 - Cannabidiol (CBD), a major nonpsychotropic constituent of Cannabis, has multiple pharmacological actions, including anxiolytic, antipsychotic, antiemetic and anti-inflammatory properties. However, little is known about its safety and side effect profile in animals and humans. This review describes in vivo and in vitro reports of CBD administration across a wide range of concentrations, based on reports retrieved from Web of Science, Scielo and Medline. The keywords searched were "cannabinoids", "cannabidiol" and "side effects". Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature), does not affect gastrointestinal transit and does not alter psychomotor or psychological functions. Also, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Conversely, some studies reported that this cannabinoid can induce some side effects, including inhibition of hepatic drug metabolism, alterations of in vitro cell viability, decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters. Based on recent advances in cannabinoid administration in humans, controlled CBD may be safe in humans and animals. However, further studies are needed to clarify these reported in vitro and in vivo side effects. SN - 2212-3911 UR - https://www.unboundmedicine.com/medline/citation/22129319/abstract/Safety_and_Side_Effects_of_C L2 - http://www.eurekaselect.com/75752/article DB - PRIME DP - Unbound Medicine ER -