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Intake of alcohol and risk of adult-onset asthma.

Abstract

AIM

To examine the association between intake of alcohol and risk of adult-onset asthma.

METHODS

Using data from two multidisciplinary questionnaire surveys we prospectively studied 19,349 twins, 12-41 years of age, from the nationwide Danish Twin Registry.

RESULTS

The eight-year incidence of asthma was 4.3%. After adjustment for sex, age, BMI, physical activity, educational level and smoking, the risk of new-onset asthma was significantly related to overall alcohol intake in a U-shaped manner with the lowest risk observed in the group with a moderate weekly intake of alcohol (1-6 units/week), p = 0.006. The highest risk of asthma was observed in rare/never drinkers (<1 unit/month), OR = 1.59 (1.25-2.02), p = 0.000, whereas the risk of asthma in heavy daily drinkers (≥4 units/day) was also increased, however not statistically significant, OR = 1.13 (0.54-2.36), p = 0.747. The risk of new-onset asthma was lower for subjects with wine preference (3.3%) compared with beer preference (4.3%) or no preference (4.4%). After multivariable adjustment, wine preference was inversely related to incident asthma compared with beer preference. However, this finding was not statistically significant, OR = 0.87 (0.51-1.46), p = 0.590.

CONCLUSION

Alcohol intake is associated with new-onset asthma in adults with a U-shaped association between amount of alcohol intake and the risk of asthma.

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  • Authors+Show Affiliations

    ,

    Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.

    , , , , , ,

    Source

    Respiratory medicine 106:2 2012 Feb pg 184-8

    MeSH

    Adolescent
    Adult
    Age of Onset
    Alcohol Drinking
    Asthma
    Beer
    Body Mass Index
    Child
    Denmark
    Female
    Humans
    Male
    Prevalence
    Prospective Studies
    Risk Factors
    Smoking
    Surveys and Questionnaires
    Wine
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22129491

    Citation

    Lieberoth, Sofie, et al. "Intake of Alcohol and Risk of Adult-onset Asthma." Respiratory Medicine, vol. 106, no. 2, 2012, pp. 184-8.
    Lieberoth S, Backer V, Kyvik KO, et al. Intake of alcohol and risk of adult-onset asthma. Respir Med. 2012;106(2):184-8.
    Lieberoth, S., Backer, V., Kyvik, K. O., Skadhauge, L. R., Tolstrup, J. S., Grønbæk, M., ... Thomsen, S. F. (2012). Intake of alcohol and risk of adult-onset asthma. Respiratory Medicine, 106(2), pp. 184-8. doi:10.1016/j.rmed.2011.11.004.
    Lieberoth S, et al. Intake of Alcohol and Risk of Adult-onset Asthma. Respir Med. 2012;106(2):184-8. PubMed PMID: 22129491.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of alcohol and risk of adult-onset asthma. AU - Lieberoth,Sofie, AU - Backer,Vibeke, AU - Kyvik,Kirsten Ohm, AU - Skadhauge,Lars Rauff, AU - Tolstrup,Janne Schurmann, AU - Grønbæk,Morten, AU - Linneberg,Allan, AU - Thomsen,Simon Francis, Y1 - 2011/11/29/ PY - 2011/10/10/received PY - 2011/11/05/revised PY - 2011/11/07/accepted PY - 2011/12/2/entrez PY - 2011/12/2/pubmed PY - 2012/3/1/medline SP - 184 EP - 8 JF - Respiratory medicine JO - Respir Med VL - 106 IS - 2 N2 - AIM: To examine the association between intake of alcohol and risk of adult-onset asthma. METHODS: Using data from two multidisciplinary questionnaire surveys we prospectively studied 19,349 twins, 12-41 years of age, from the nationwide Danish Twin Registry. RESULTS: The eight-year incidence of asthma was 4.3%. After adjustment for sex, age, BMI, physical activity, educational level and smoking, the risk of new-onset asthma was significantly related to overall alcohol intake in a U-shaped manner with the lowest risk observed in the group with a moderate weekly intake of alcohol (1-6 units/week), p = 0.006. The highest risk of asthma was observed in rare/never drinkers (<1 unit/month), OR = 1.59 (1.25-2.02), p = 0.000, whereas the risk of asthma in heavy daily drinkers (≥4 units/day) was also increased, however not statistically significant, OR = 1.13 (0.54-2.36), p = 0.747. The risk of new-onset asthma was lower for subjects with wine preference (3.3%) compared with beer preference (4.3%) or no preference (4.4%). After multivariable adjustment, wine preference was inversely related to incident asthma compared with beer preference. However, this finding was not statistically significant, OR = 0.87 (0.51-1.46), p = 0.590. CONCLUSION: Alcohol intake is associated with new-onset asthma in adults with a U-shaped association between amount of alcohol intake and the risk of asthma. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/22129491/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(11)00391-X DB - PRIME DP - Unbound Medicine ER -