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Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice.
Biol Pharm Bull. 2011; 34(12):1877-80.BP

Abstract

Gelsemium elegans BENTH and its crude extract are widely used to treat pain in China despite its apparent toxicity. The analgesic effects of gelsenicine, an active component of G. elegans, however, have not been reported. The current study examined potential analgesic effects of subcutaneously injected gelsenicine using acetic acid-induced writhing, formalin-induced nociceptive behavior, and thermal hyperalgesia caused by chronic constriction injury (CCI) in mice. Gelsenicine produced dose-dependent analgesic effects in both inflammatory and neuropathic pain models. The ED(50), for either the inflammatory pain (10.4 µg/kg for writhing test, 7.4 µg/kg for formalin test) or neuropathic pain (9.8 µg/kg for thermal hyperalgesia caused by CCI model), was far below the LD(50) (95% confidence interval at 100-200 µg/kg). Repeated subcutaneous injections of gelsenicine in CCI mice led to sustained attenuation of neuropathic pain after drug discontinuation. These results revealed that gelsenicine could be used safely to attenuate both inflammatory and neuropathic pain.

Authors+Show Affiliations

Department of Pharmacology, College of Pharmacy, Fujian Medical University, Fujian 350004, People’s Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22130245

Citation

Liu, Ming, et al. "Gelsenicine From Gelsemium Elegans Attenuates Neuropathic and Inflammatory Pain in Mice." Biological & Pharmaceutical Bulletin, vol. 34, no. 12, 2011, pp. 1877-80.
Liu M, Shen J, Liu H, et al. Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice. Biol Pharm Bull. 2011;34(12):1877-80.
Liu, M., Shen, J., Liu, H., Xu, Y., Su, Y. P., Yang, J., & Yu, C. X. (2011). Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice. Biological & Pharmaceutical Bulletin, 34(12), 1877-80.
Liu M, et al. Gelsenicine From Gelsemium Elegans Attenuates Neuropathic and Inflammatory Pain in Mice. Biol Pharm Bull. 2011;34(12):1877-80. PubMed PMID: 22130245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice. AU - Liu,Ming, AU - Shen,Jie, AU - Liu,Hao, AU - Xu,Ying, AU - Su,Yan-Ping, AU - Yang,Jian, AU - Yu,Chang-Xi, PY - 2011/12/2/entrez PY - 2011/12/2/pubmed PY - 2012/3/31/medline SP - 1877 EP - 80 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 34 IS - 12 N2 - Gelsemium elegans BENTH and its crude extract are widely used to treat pain in China despite its apparent toxicity. The analgesic effects of gelsenicine, an active component of G. elegans, however, have not been reported. The current study examined potential analgesic effects of subcutaneously injected gelsenicine using acetic acid-induced writhing, formalin-induced nociceptive behavior, and thermal hyperalgesia caused by chronic constriction injury (CCI) in mice. Gelsenicine produced dose-dependent analgesic effects in both inflammatory and neuropathic pain models. The ED(50), for either the inflammatory pain (10.4 µg/kg for writhing test, 7.4 µg/kg for formalin test) or neuropathic pain (9.8 µg/kg for thermal hyperalgesia caused by CCI model), was far below the LD(50) (95% confidence interval at 100-200 µg/kg). Repeated subcutaneous injections of gelsenicine in CCI mice led to sustained attenuation of neuropathic pain after drug discontinuation. These results revealed that gelsenicine could be used safely to attenuate both inflammatory and neuropathic pain. SN - 1347-5215 UR - https://www.unboundmedicine.com/medline/citation/22130245/Gelsenicine_from_Gelsemium_elegans_attenuates_neuropathic_and_inflammatory_pain_in_mice_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/34.1877?from=PubMed DB - PRIME DP - Unbound Medicine ER -