Tags

Type your tag names separated by a space and hit enter

Risk of depression in diabetes is highest for young persons using oral anti-diabetic agents.
Diabet Med. 2012 Apr; 29(4):509-14.DM

Abstract

AIMS

Previous studies report an increased risk of depression in patients with diabetes, but there is little knowledge about if or how the risk varies according to sex, groups of age and different type of treatments for the diabetes. We therefore aimed to investigate the risk of depression in different types of treatment for diabetes and in subgroups of age and sex.

METHODS

Data on the Norwegian population from 20 years of age being prescribed antidepressants (n = 253 668) and anti-diabetic agents (n = 121 392) in 2006 was obtained from the National Register of Prescriptions and analysed in a cross-sectional design.

RESULTS

Individuals using insulin in monotherapy (n = 29 611) had an age- and sex-adjusted odds ratio of 1.47 (95% CI 1.42-1.53) for receiving antidepressants. Corresponding odds ratios for individuals receiving oral anti-diabetic agents in monotherapy (n = 76 387) and for those who received both insulin and oral anti-diabetic agents (n = 15 394) were 1.44 (95% CI 1.41-1.47) and 1.82 (95% CI 1.80-1.97), respectively. No major differences in risk according to age were found for persons receiving insulin in monotherapy, while a marked and inverse association between age and risk of receiving antidepressants was found for those receiving oral anti-diabetic agents. Highest risk of antidepressant treatment [odds ratio 4.15 (95% CI 3.12-5.52)] was found for patients receiving both oral anti-diabetic agents and insulin at 30-39 years. The risk was equally increased among men and women.

CONCLUSIONS

The risk of depression among patients with diabetes varies strongly according to age and type of treatment for diabetes.

Authors+Show Affiliations

Department of Clinical Medicine, Section of Psychiatry, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway. line.iden.berge@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22133020

Citation

Berge, L I., et al. "Risk of Depression in Diabetes Is Highest for Young Persons Using Oral Anti-diabetic Agents." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 29, no. 4, 2012, pp. 509-14.
Berge LI, Riise T, Fasmer OB, et al. Risk of depression in diabetes is highest for young persons using oral anti-diabetic agents. Diabet Med. 2012;29(4):509-14.
Berge, L. I., Riise, T., Fasmer, O. B., Lund, A., Oedegaard, K. J., & Hundal, O. (2012). Risk of depression in diabetes is highest for young persons using oral anti-diabetic agents. Diabetic Medicine : a Journal of the British Diabetic Association, 29(4), 509-14. https://doi.org/10.1111/j.1464-5491.2011.03530.x
Berge LI, et al. Risk of Depression in Diabetes Is Highest for Young Persons Using Oral Anti-diabetic Agents. Diabet Med. 2012;29(4):509-14. PubMed PMID: 22133020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of depression in diabetes is highest for young persons using oral anti-diabetic agents. AU - Berge,L I, AU - Riise,T, AU - Fasmer,O B, AU - Lund,A, AU - Oedegaard,K J, AU - Hundal,O, PY - 2011/12/3/entrez PY - 2011/12/3/pubmed PY - 2012/7/18/medline SP - 509 EP - 14 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 29 IS - 4 N2 - AIMS: Previous studies report an increased risk of depression in patients with diabetes, but there is little knowledge about if or how the risk varies according to sex, groups of age and different type of treatments for the diabetes. We therefore aimed to investigate the risk of depression in different types of treatment for diabetes and in subgroups of age and sex. METHODS: Data on the Norwegian population from 20 years of age being prescribed antidepressants (n = 253 668) and anti-diabetic agents (n = 121 392) in 2006 was obtained from the National Register of Prescriptions and analysed in a cross-sectional design. RESULTS: Individuals using insulin in monotherapy (n = 29 611) had an age- and sex-adjusted odds ratio of 1.47 (95% CI 1.42-1.53) for receiving antidepressants. Corresponding odds ratios for individuals receiving oral anti-diabetic agents in monotherapy (n = 76 387) and for those who received both insulin and oral anti-diabetic agents (n = 15 394) were 1.44 (95% CI 1.41-1.47) and 1.82 (95% CI 1.80-1.97), respectively. No major differences in risk according to age were found for persons receiving insulin in monotherapy, while a marked and inverse association between age and risk of receiving antidepressants was found for those receiving oral anti-diabetic agents. Highest risk of antidepressant treatment [odds ratio 4.15 (95% CI 3.12-5.52)] was found for patients receiving both oral anti-diabetic agents and insulin at 30-39 years. The risk was equally increased among men and women. CONCLUSIONS: The risk of depression among patients with diabetes varies strongly according to age and type of treatment for diabetes. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/22133020/Risk_of_depression_in_diabetes_is_highest_for_young_persons_using_oral_anti_diabetic_agents_ L2 - https://doi.org/10.1111/j.1464-5491.2011.03530.x DB - PRIME DP - Unbound Medicine ER -