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Updated bioavailability and 48 h excretion profile of flavan-3-ols from green tea in humans.
Int J Food Sci Nutr. 2012 Aug; 63(5):513-21.IJ

Abstract

Green tea is a popular beverage, prepared with infusion of unfermented dried leaves of Camellia sinensis, and is one of the most relevant sources of polyphenolic compounds in the human diet. This study reports green tea flavan-3-ol absorption, metabolism and complete urinary excretion up to 48 h in 20 healthy volunteers. Urinary and tea samples were analysed by high-performance liquid chromatography coupled with tandem mass spectrometry. Green tea contained monomeric flavan-3-ols and proanthocyanidins with a total polyphenol content of 728 μmol. A total of 41 metabolites were identified in urines, all present in conjugated forms. Among these, six colonic metabolites of green tea flavan-3-ols were identified for the first time after green tea consumption in humans. The average 48 h bioavailability was close to 62%, major contributors being microbial metabolites. Some volunteer showed a 100% absorption/excretion, whereas some others were unable to efficiently absorb/excrete this class of flavonoids. This suggests that colonic ring fission metabolism could be relevant in the putative bioactivity of green tea polyphenols.

Authors+Show Affiliations

Human Nutrition Unit, The φ², Laboratory of Phytochemicals in Physiology, Department of Public Health, University of Parma, Parma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22133145

Citation

Calani, Luca, et al. "Updated Bioavailability and 48 H Excretion Profile of Flavan-3-ols From Green Tea in Humans." International Journal of Food Sciences and Nutrition, vol. 63, no. 5, 2012, pp. 513-21.
Calani L, Del Rio D, Luisa Callegari M, et al. Updated bioavailability and 48 h excretion profile of flavan-3-ols from green tea in humans. Int J Food Sci Nutr. 2012;63(5):513-21.
Calani, L., Del Rio, D., Luisa Callegari, M., Morelli, L., & Brighenti, F. (2012). Updated bioavailability and 48 h excretion profile of flavan-3-ols from green tea in humans. International Journal of Food Sciences and Nutrition, 63(5), 513-21. https://doi.org/10.3109/09637486.2011.640311
Calani L, et al. Updated Bioavailability and 48 H Excretion Profile of Flavan-3-ols From Green Tea in Humans. Int J Food Sci Nutr. 2012;63(5):513-21. PubMed PMID: 22133145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Updated bioavailability and 48 h excretion profile of flavan-3-ols from green tea in humans. AU - Calani,Luca, AU - Del Rio,Daniele, AU - Luisa Callegari,Maria, AU - Morelli,Lorenzo, AU - Brighenti,Furio, Y1 - 2011/12/02/ PY - 2011/12/3/entrez PY - 2011/12/3/pubmed PY - 2012/12/10/medline SP - 513 EP - 21 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 63 IS - 5 N2 - Green tea is a popular beverage, prepared with infusion of unfermented dried leaves of Camellia sinensis, and is one of the most relevant sources of polyphenolic compounds in the human diet. This study reports green tea flavan-3-ol absorption, metabolism and complete urinary excretion up to 48 h in 20 healthy volunteers. Urinary and tea samples were analysed by high-performance liquid chromatography coupled with tandem mass spectrometry. Green tea contained monomeric flavan-3-ols and proanthocyanidins with a total polyphenol content of 728 μmol. A total of 41 metabolites were identified in urines, all present in conjugated forms. Among these, six colonic metabolites of green tea flavan-3-ols were identified for the first time after green tea consumption in humans. The average 48 h bioavailability was close to 62%, major contributors being microbial metabolites. Some volunteer showed a 100% absorption/excretion, whereas some others were unable to efficiently absorb/excrete this class of flavonoids. This suggests that colonic ring fission metabolism could be relevant in the putative bioactivity of green tea polyphenols. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/22133145/Updated_bioavailability_and_48_h_excretion_profile_of_flavan_3_ols_from_green_tea_in_humans_ L2 - https://www.tandfonline.com/doi/full/10.3109/09637486.2011.640311 DB - PRIME DP - Unbound Medicine ER -