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A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men.
Brain Res 2012; 1431:46-52BR

Abstract

RATIONALE

The endocannabinoid system is under active investigation as a pharmacological target for obesity management due to its role in appetite regulation and metabolism. Exogenous cannabinoids such as tetrahydrocannabinol (THC) stimulate appetite and food intake. However, there are no controlled observations directly linking THC to changes of most of the appetite hormones.

OBJECTIVES

We took the opportunity afforded by a placebo-controlled trial of smoked medicinal cannabis for HIV-associated neuropathic pain to evaluate the effects of THC on the appetite hormones ghrelin, leptin and PYY, as well as on insulin.

METHODS

In this double-blind cross-over study, each subject was exposed to both active cannabis (THC) and placebo.

RESULTS

Compared to placebo, cannabis administration was associated with significant increases in plasma levels of ghrelin and leptin, and decreases in PYY, but did not significantly influence insulin levels.

CONCLUSION

These findings are consistent with modulation of appetite hormones mediated through endogenous cannabinoid receptors, independent of glucose metabolism.

Authors+Show Affiliations

Center for Medicinal Cannabis Research (CMCR) and HIV Neurobehavioral Research Center (HNRC), University of California, San Diego, USA. roellis@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22133305

Citation

Riggs, Patricia K., et al. "A Pilot Study of the Effects of Cannabis On Appetite Hormones in HIV-infected Adult Men." Brain Research, vol. 1431, 2012, pp. 46-52.
Riggs PK, Vaida F, Rossi SS, et al. A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. Brain Res. 2012;1431:46-52.
Riggs, P. K., Vaida, F., Rossi, S. S., Sorkin, L. S., Gouaux, B., Grant, I., & Ellis, R. J. (2012). A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. Brain Research, 1431, pp. 46-52. doi:10.1016/j.brainres.2011.11.001.
Riggs PK, et al. A Pilot Study of the Effects of Cannabis On Appetite Hormones in HIV-infected Adult Men. Brain Res. 2012 Jan 11;1431:46-52. PubMed PMID: 22133305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. AU - Riggs,Patricia K, AU - Vaida,Florin, AU - Rossi,Steven S, AU - Sorkin,Linda S, AU - Gouaux,Ben, AU - Grant,Igor, AU - Ellis,Ronald J, Y1 - 2011/11/07/ PY - 2011/07/28/received PY - 2011/10/18/revised PY - 2011/11/02/accepted PY - 2011/12/3/entrez PY - 2011/12/3/pubmed PY - 2012/4/24/medline SP - 46 EP - 52 JF - Brain research JO - Brain Res. VL - 1431 N2 - RATIONALE: The endocannabinoid system is under active investigation as a pharmacological target for obesity management due to its role in appetite regulation and metabolism. Exogenous cannabinoids such as tetrahydrocannabinol (THC) stimulate appetite and food intake. However, there are no controlled observations directly linking THC to changes of most of the appetite hormones. OBJECTIVES: We took the opportunity afforded by a placebo-controlled trial of smoked medicinal cannabis for HIV-associated neuropathic pain to evaluate the effects of THC on the appetite hormones ghrelin, leptin and PYY, as well as on insulin. METHODS: In this double-blind cross-over study, each subject was exposed to both active cannabis (THC) and placebo. RESULTS: Compared to placebo, cannabis administration was associated with significant increases in plasma levels of ghrelin and leptin, and decreases in PYY, but did not significantly influence insulin levels. CONCLUSION: These findings are consistent with modulation of appetite hormones mediated through endogenous cannabinoid receptors, independent of glucose metabolism. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/22133305/abstract/A_pilot_study_of_the_effects_o L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(11)02028-2 DB - PRIME DP - Unbound Medicine ER -