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Duration of maternally derived antibody against measles: a seroepidemiological study of infants aged under 8 months in Qinghai, China.
Vaccine. 2012 Jan 17; 30(4):752-7.V

Abstract

To estimate the sero-prevalence of protective maternal measles antibodies among young infants and examine patterns of waning immunity in one of the poorest provinces in China, infants aged under 8 months and their mothers were randomly selected by multi-stage probabilistic sampling and blood samples were collected. Measles-specific IgG antibodies were measured in all serum samples by enzyme-linked immunosorbent assay. We determined measles-specific antibody titres for 477 pairs of infants and their mothers. After excluding 44 sub-clinical measles infection in infants, the measles antibody titres were ≧1:200, ≧1:800, and ≧1:3200 in 79.2%, 46.9%, and 17.8% of the 433 infants, respectively. The proportion of infants with titre ≧1:800 declined with age from 90.2% in newborns to 45.5% and 14.9% in the fourth and eighth month, respectively. Among the 433 mothers, measles antibody titres were ≧1:800 in 94.0%. Multivariate regression analysis showed that residence, mother's antibody levels and infant's age were significantly associated with infants' having a measles antibody titre ≧1:800. The relatively rapid decay of protective antibody in infants suggests that an earlier administration of the first dose of measles vaccination should be considered in China and a high quality interventional study is needed to decide the optimal schedule of measles immunization.

Authors+Show Affiliations

Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan. xinwzhang@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22133513

Citation

Zhang, Xinwei, et al. "Duration of Maternally Derived Antibody Against Measles: a Seroepidemiological Study of Infants Aged Under 8 Months in Qinghai, China." Vaccine, vol. 30, no. 4, 2012, pp. 752-7.
Zhang X, Shirayama Y, Zhang Y, et al. Duration of maternally derived antibody against measles: a seroepidemiological study of infants aged under 8 months in Qinghai, China. Vaccine. 2012;30(4):752-7.
Zhang, X., Shirayama, Y., Zhang, Y., Ba, W., Ikeda, N., Mori, R., & Shibuya, K. (2012). Duration of maternally derived antibody against measles: a seroepidemiological study of infants aged under 8 months in Qinghai, China. Vaccine, 30(4), 752-7. https://doi.org/10.1016/j.vaccine.2011.11.078
Zhang X, et al. Duration of Maternally Derived Antibody Against Measles: a Seroepidemiological Study of Infants Aged Under 8 Months in Qinghai, China. Vaccine. 2012 Jan 17;30(4):752-7. PubMed PMID: 22133513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of maternally derived antibody against measles: a seroepidemiological study of infants aged under 8 months in Qinghai, China. AU - Zhang,Xinwei, AU - Shirayama,Yoshihisa, AU - Zhang,Yongji, AU - Ba,Wensheng, AU - Ikeda,Nayu, AU - Mori,Rintaro, AU - Shibuya,Kenji, Y1 - 2011/11/29/ PY - 2011/07/28/received PY - 2011/11/11/revised PY - 2011/11/18/accepted PY - 2011/12/3/entrez PY - 2011/12/3/pubmed PY - 2012/5/4/medline SP - 752 EP - 7 JF - Vaccine JO - Vaccine VL - 30 IS - 4 N2 - To estimate the sero-prevalence of protective maternal measles antibodies among young infants and examine patterns of waning immunity in one of the poorest provinces in China, infants aged under 8 months and their mothers were randomly selected by multi-stage probabilistic sampling and blood samples were collected. Measles-specific IgG antibodies were measured in all serum samples by enzyme-linked immunosorbent assay. We determined measles-specific antibody titres for 477 pairs of infants and their mothers. After excluding 44 sub-clinical measles infection in infants, the measles antibody titres were ≧1:200, ≧1:800, and ≧1:3200 in 79.2%, 46.9%, and 17.8% of the 433 infants, respectively. The proportion of infants with titre ≧1:800 declined with age from 90.2% in newborns to 45.5% and 14.9% in the fourth and eighth month, respectively. Among the 433 mothers, measles antibody titres were ≧1:800 in 94.0%. Multivariate regression analysis showed that residence, mother's antibody levels and infant's age were significantly associated with infants' having a measles antibody titre ≧1:800. The relatively rapid decay of protective antibody in infants suggests that an earlier administration of the first dose of measles vaccination should be considered in China and a high quality interventional study is needed to decide the optimal schedule of measles immunization. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22133513/Duration_of_maternally_derived_antibody_against_measles:_a_seroepidemiological_study_of_infants_aged_under_8_months_in_Qinghai_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)01874-3 DB - PRIME DP - Unbound Medicine ER -