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Skeletal muscle is protected from disuse in hibernating dauria ground squirrels.

Abstract

The purpose of this study is to test the hypothesis that muscle fibers are protected from undue atrophy in hibernating dauria ground squirrels (Spermophilus dauricus, Brandt). Muscle mass, fiber cross sectional area (CSA, video analysis) and fiber type distribution (m-ATPase staining) were determined in extensor digitorum longus (EDL) muscle from non-hibernating control animals (Pre-H), from animals who hibernated for one (H1) or two (H2) months, and from animals 2-4days after arousal (Post-H; N=8 each). Muscle wet weight decreased less than body weight in hibernating animals, resulting in a steady increase in muscle-to-body mass ratio (+37% in Post-H compared to Pre-H, p<0.001). In the Pre-H group, Type I (6.3±2.0%) and II (93.7±2.0%) fiber CSAs were 1719±201 and 2261±287μm(2), respectively. There was a tendency (n.s.) of larger CSA of type I in hibernators compared to pre-H. In the Post-H group, fiber CSA and type distribution were not different from Pre-H. We are the first to report data on EDL fiber type distribution and confirm a protective effect that prevents muscle atrophy in spite of prolonged disuse during hibernation in dauria ground squirrels.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, 710069, China. gaoyunf@nwu.edu.cn

    , , , , ,

    Source

    MeSH

    Animals
    Body Weights and Measures
    Hibernation
    Muscle Fibers, Skeletal
    Muscle, Skeletal
    Sciuridae

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22133905

    Citation

    TY - JOUR T1 - Skeletal muscle is protected from disuse in hibernating dauria ground squirrels. AU - Gao,Yun-Fang, AU - Wang,Jun, AU - Wang,Hui-Ping, AU - Feng,Ban, AU - Dang,Kai, AU - Wang,Qi, AU - Hinghofer-Szalkay,Helmut G, Y1 - 2011/11/22/ PY - 2011/8/3/received PY - 2011/11/9/revised PY - 2011/11/15/accepted PY - 2011/11/22/aheadofprint PY - 2011/12/3/entrez PY - 2011/12/3/pubmed PY - 2012/5/19/medline SP - 296 EP - 300 JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology JO - Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. VL - 161 IS - 3 N2 - The purpose of this study is to test the hypothesis that muscle fibers are protected from undue atrophy in hibernating dauria ground squirrels (Spermophilus dauricus, Brandt). Muscle mass, fiber cross sectional area (CSA, video analysis) and fiber type distribution (m-ATPase staining) were determined in extensor digitorum longus (EDL) muscle from non-hibernating control animals (Pre-H), from animals who hibernated for one (H1) or two (H2) months, and from animals 2-4days after arousal (Post-H; N=8 each). Muscle wet weight decreased less than body weight in hibernating animals, resulting in a steady increase in muscle-to-body mass ratio (+37% in Post-H compared to Pre-H, p<0.001). In the Pre-H group, Type I (6.3±2.0%) and II (93.7±2.0%) fiber CSAs were 1719±201 and 2261±287μm(2), respectively. There was a tendency (n.s.) of larger CSA of type I in hibernators compared to pre-H. In the Post-H group, fiber CSA and type distribution were not different from Pre-H. We are the first to report data on EDL fiber type distribution and confirm a protective effect that prevents muscle atrophy in spite of prolonged disuse during hibernation in dauria ground squirrels. SN - 1531-4332 UR - https://www.unboundmedicine.com/medline/citation/22133905/abstract/Skeletal_muscle_is_protected_from_disuse_in_hibernating_dauria_ground_squirrels_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S1095-6433(11)00324-2 ER -