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Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain.
Eur J Pharmacol. 2012 Jan 15; 674(2-3):260-4.EJ

Abstract

Neuropathic pain is caused by a lesion or disease of the somatosensory nervous system and treatment of neuropathic pain remains a challenge. The purpose of the present study was to examine the effect of ethosuximide, an anti-epileptic and relatively selective T-type calcium blocker and morphine, a prototypical opioid in the behavioral responses following the chronic constriction injury (CCI) model of neuropathic pain. Experiments were performed on eight groups (n=8) of male Sprague-Dawley rats (230-280 g). The animals were injected with saline, ethosuximide (100, 200, 300 mg/kg), morphine (4 mg/kg), and a combination of morphine (4 mg/kg) plus ethosuximide (100mg/kg, i.p.). The cold-and mechano-allodynia and thermal hyperalgesia were measured prior to surgery (the day 0) and 3, 5, 7, 14 and 21 days post surgery. Ethosuximide and morphine significantly decreased cold and mechano allodynia and thermal hyperalgesia. However, the co-administration of both drugs seems to be more effective than the ethosuximide or morphine alone on cold and mechano allodynia and thermal hyperalgesia .Our results suggest that ethosuximide block tactile and thermal hypersensitivity after the CCI model, also, ethosuximide potentiates the analgesic effects of morphine in neuropathic pain conditions and behavioral responses.

Authors+Show Affiliations

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22134003

Citation

Hamidi, Gholam Ali, et al. "Ethosuximide Reduces Allodynia and Hyperalgesia and Potentiates Morphine Effects in the Chronic Constriction Injury Model of Neuropathic Pain." European Journal of Pharmacology, vol. 674, no. 2-3, 2012, pp. 260-4.
Hamidi GA, Ramezani MH, Arani MN, et al. Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain. Eur J Pharmacol. 2012;674(2-3):260-4.
Hamidi, G. A., Ramezani, M. H., Arani, M. N., Talaei, S. A., Mesdaghinia, A., & Banafshe, H. R. (2012). Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain. European Journal of Pharmacology, 674(2-3), 260-4. https://doi.org/10.1016/j.ejphar.2011.11.026
Hamidi GA, et al. Ethosuximide Reduces Allodynia and Hyperalgesia and Potentiates Morphine Effects in the Chronic Constriction Injury Model of Neuropathic Pain. Eur J Pharmacol. 2012 Jan 15;674(2-3):260-4. PubMed PMID: 22134003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain. AU - Hamidi,Gholam Ali, AU - Ramezani,Mehdi Honarkar, AU - Arani,Meysam Noorani, AU - Talaei,Sayyed Alireza, AU - Mesdaghinia,Azam, AU - Banafshe,Hamid Reza, Y1 - 2011/11/23/ PY - 2011/06/18/received PY - 2011/11/05/revised PY - 2011/11/10/accepted PY - 2011/12/3/entrez PY - 2011/12/3/pubmed PY - 2012/5/4/medline SP - 260 EP - 4 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 674 IS - 2-3 N2 - Neuropathic pain is caused by a lesion or disease of the somatosensory nervous system and treatment of neuropathic pain remains a challenge. The purpose of the present study was to examine the effect of ethosuximide, an anti-epileptic and relatively selective T-type calcium blocker and morphine, a prototypical opioid in the behavioral responses following the chronic constriction injury (CCI) model of neuropathic pain. Experiments were performed on eight groups (n=8) of male Sprague-Dawley rats (230-280 g). The animals were injected with saline, ethosuximide (100, 200, 300 mg/kg), morphine (4 mg/kg), and a combination of morphine (4 mg/kg) plus ethosuximide (100mg/kg, i.p.). The cold-and mechano-allodynia and thermal hyperalgesia were measured prior to surgery (the day 0) and 3, 5, 7, 14 and 21 days post surgery. Ethosuximide and morphine significantly decreased cold and mechano allodynia and thermal hyperalgesia. However, the co-administration of both drugs seems to be more effective than the ethosuximide or morphine alone on cold and mechano allodynia and thermal hyperalgesia .Our results suggest that ethosuximide block tactile and thermal hypersensitivity after the CCI model, also, ethosuximide potentiates the analgesic effects of morphine in neuropathic pain conditions and behavioral responses. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/22134003/Ethosuximide_reduces_allodynia_and_hyperalgesia_and_potentiates_morphine_effects_in_the_chronic_constriction_injury_model_of_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)01478-6 DB - PRIME DP - Unbound Medicine ER -