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Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.

Abstract

PURPOSE OF REVIEW

Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans are deprived of choline. In the last few years, there have been significant advances in our understanding of the mechanisms that influence choline requirements in humans and in our understanding of choline's effects on liver function. These advances are useful in elucidating why nonalcoholic fatty liver disease (NAFLD) occurs and progresses sometimes to hepatocarcinogenesis.

RECENT FINDINGS

Humans eating low-choline diets develop fatty liver and liver damage. This dietary requirement for choline is modulated by estrogen and by single-nucleotide polymorphisms in specific genes of choline and folate metabolism. The spectrum of choline's effects on liver range from steatosis to development of hepatocarcinomas, and several mechanisms for these effects have been identified. They include abnormal phospholipid synthesis, defects in lipoprotein secretion, oxidative damage caused by mitochondrial dysfunction, and endoplasmic reticulum stress. Furthermore, the hepatic steatosis phenotype can be characterized more fully via metabolomic signatures and is influenced by the gut microbiome. Importantly, the intricate connection between liver function, one-carbon metabolism, and energy metabolism is just beginning to be elucidated.

SUMMARY

Choline influences liver function, and the dietary requirement for this nutrient varies depending on an individual's genotype and estrogen status. Understanding these individual differences is important for gastroenterologists seeking to understand why some individuals develop NAFLD and others do not, and why some patients tolerate total parenteral nutrition and others develop liver dysfunction.

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  • Authors+Show Affiliations

    ,

    University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, North Carolina, USA.

    Source

    Current opinion in gastroenterology 28:2 2012 Mar pg 159-65

    MeSH

    Animals
    Choline
    Disease Progression
    Fatty Liver
    Humans
    Liver
    Metabolic Syndrome
    Non-alcoholic Fatty Liver Disease

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22134222

    Citation

    Corbin, Karen D., and Steven H. Zeisel. "Choline Metabolism Provides Novel Insights Into Nonalcoholic Fatty Liver Disease and Its Progression." Current Opinion in Gastroenterology, vol. 28, no. 2, 2012, pp. 159-65.
    Corbin KD, Zeisel SH. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol. 2012;28(2):159-65.
    Corbin, K. D., & Zeisel, S. H. (2012). Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Current Opinion in Gastroenterology, 28(2), pp. 159-65. doi:10.1097/MOG.0b013e32834e7b4b.
    Corbin KD, Zeisel SH. Choline Metabolism Provides Novel Insights Into Nonalcoholic Fatty Liver Disease and Its Progression. Curr Opin Gastroenterol. 2012;28(2):159-65. PubMed PMID: 22134222.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. AU - Corbin,Karen D, AU - Zeisel,Steven H, PY - 2011/12/3/entrez PY - 2011/12/3/pubmed PY - 2012/6/22/medline SP - 159 EP - 65 JF - Current opinion in gastroenterology JO - Curr. Opin. Gastroenterol. VL - 28 IS - 2 N2 - PURPOSE OF REVIEW: Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans are deprived of choline. In the last few years, there have been significant advances in our understanding of the mechanisms that influence choline requirements in humans and in our understanding of choline's effects on liver function. These advances are useful in elucidating why nonalcoholic fatty liver disease (NAFLD) occurs and progresses sometimes to hepatocarcinogenesis. RECENT FINDINGS: Humans eating low-choline diets develop fatty liver and liver damage. This dietary requirement for choline is modulated by estrogen and by single-nucleotide polymorphisms in specific genes of choline and folate metabolism. The spectrum of choline's effects on liver range from steatosis to development of hepatocarcinomas, and several mechanisms for these effects have been identified. They include abnormal phospholipid synthesis, defects in lipoprotein secretion, oxidative damage caused by mitochondrial dysfunction, and endoplasmic reticulum stress. Furthermore, the hepatic steatosis phenotype can be characterized more fully via metabolomic signatures and is influenced by the gut microbiome. Importantly, the intricate connection between liver function, one-carbon metabolism, and energy metabolism is just beginning to be elucidated. SUMMARY: Choline influences liver function, and the dietary requirement for this nutrient varies depending on an individual's genotype and estrogen status. Understanding these individual differences is important for gastroenterologists seeking to understand why some individuals develop NAFLD and others do not, and why some patients tolerate total parenteral nutrition and others develop liver dysfunction. SN - 1531-7056 UR - https://www.unboundmedicine.com/medline/citation/22134222/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=22134222 DB - PRIME DP - Unbound Medicine ER -