Tags

Type your tag names separated by a space and hit enter

Antibacterial activity of some African medicinal plants used traditionally against infectious diseases.
Pharm Biol. 2012 Apr; 50(4):481-9.PB

Abstract

CONTEXT

Plants are known to play a crucial role in African traditional medicine for the treatment of infection diseases.

OBJECTIVES

To investigate the claimed antimicrobial properties of plants traditionally used in African countries, providing scientific validation for their use.

MATERIALS AND METHODS

Eighty-three polar and non-polar extracts from 22 medicinal plants were screened for their antibacterial activity against Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and Mycobacterium smegmatis using the broth microdilution method.

RESULTS AND DISCUSSION

In vitro antibacterial activity against one or more tested bacteria was shown by 83% of the extracts. The highest activity was obtained with the methanol extracts of the aerial parts of Acacia karroo Hayne (Fabaceae) and Anacardium occidentale L. (Anacardiaceae) and the roots of Bridelia cathartica G. Bertol (Euphorbiaceae), against S. aureus (minimum inhibitory concentration (MIC) = 7.5 µg/mL). The same MIC values were exhibited against E. faecalis by the methanol extract of A. occidentale, the dichloromethane and methanol extracts of B. cathartica and the ethyl acetate extract of Momordica balsamina l. (Curcubitaceae) leaves. Gram-negative bacteria were less sensitive; the growth of P. aeruginosa was significantly inhibited (MIC = 31 µg/mL) by the n-hexane and methanol extracts of Gomphocarpus fruticosus (l.) Ait. (Asclepiadaceae) fruits and by the dichloromethane extract of Trichilia emetica Vahl (Meliaceae) seeds. Most of the active extracts were rich in fenols/flavonoids.

CONCLUSION

This study supports the use of most of the studied plants in traditional medicine, for the treatment of infectious diseases. Some of them are worthy of further investigation.

Authors+Show Affiliations

Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, Lisbon, Portugal.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22136524

Citation

Madureira, Ana M., et al. "Antibacterial Activity of some African Medicinal Plants Used Traditionally Against Infectious Diseases." Pharmaceutical Biology, vol. 50, no. 4, 2012, pp. 481-9.
Madureira AM, Ramalhete C, Mulhovo S, et al. Antibacterial activity of some African medicinal plants used traditionally against infectious diseases. Pharm Biol. 2012;50(4):481-9.
Madureira, A. M., Ramalhete, C., Mulhovo, S., Duarte, A., & Ferreira, M. J. (2012). Antibacterial activity of some African medicinal plants used traditionally against infectious diseases. Pharmaceutical Biology, 50(4), 481-9. https://doi.org/10.3109/13880209.2011.615841
Madureira AM, et al. Antibacterial Activity of some African Medicinal Plants Used Traditionally Against Infectious Diseases. Pharm Biol. 2012;50(4):481-9. PubMed PMID: 22136524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial activity of some African medicinal plants used traditionally against infectious diseases. AU - Madureira,Ana M, AU - Ramalhete,Cátia, AU - Mulhovo,Silva, AU - Duarte,Aida, AU - Ferreira,Maria-José U, Y1 - 2011/12/02/ PY - 2011/12/6/entrez PY - 2011/12/6/pubmed PY - 2012/7/11/medline SP - 481 EP - 9 JF - Pharmaceutical biology JO - Pharm Biol VL - 50 IS - 4 N2 - CONTEXT: Plants are known to play a crucial role in African traditional medicine for the treatment of infection diseases. OBJECTIVES: To investigate the claimed antimicrobial properties of plants traditionally used in African countries, providing scientific validation for their use. MATERIALS AND METHODS: Eighty-three polar and non-polar extracts from 22 medicinal plants were screened for their antibacterial activity against Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and Mycobacterium smegmatis using the broth microdilution method. RESULTS AND DISCUSSION: In vitro antibacterial activity against one or more tested bacteria was shown by 83% of the extracts. The highest activity was obtained with the methanol extracts of the aerial parts of Acacia karroo Hayne (Fabaceae) and Anacardium occidentale L. (Anacardiaceae) and the roots of Bridelia cathartica G. Bertol (Euphorbiaceae), against S. aureus (minimum inhibitory concentration (MIC) = 7.5 µg/mL). The same MIC values were exhibited against E. faecalis by the methanol extract of A. occidentale, the dichloromethane and methanol extracts of B. cathartica and the ethyl acetate extract of Momordica balsamina l. (Curcubitaceae) leaves. Gram-negative bacteria were less sensitive; the growth of P. aeruginosa was significantly inhibited (MIC = 31 µg/mL) by the n-hexane and methanol extracts of Gomphocarpus fruticosus (l.) Ait. (Asclepiadaceae) fruits and by the dichloromethane extract of Trichilia emetica Vahl (Meliaceae) seeds. Most of the active extracts were rich in fenols/flavonoids. CONCLUSION: This study supports the use of most of the studied plants in traditional medicine, for the treatment of infectious diseases. Some of them are worthy of further investigation. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/22136524/Antibacterial_activity_of_some_African_medicinal_plants_used_traditionally_against_infectious_diseases_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2011.615841 DB - PRIME DP - Unbound Medicine ER -