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Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials.
Am Heart J. 2011 Dec; 162(6):959-65.AH

Abstract

BACKGROUND

Previous studies suggest that L-arginine, an amino acid and a substrate of nitric oxide synthase, may have blood pressure (BP)-lowering effect. Because some studies were performed with limited number of patients with hypertension and therefore limited statistical power with sometimes inconsistent results, we aimed to examine the effect of oral L-arginine supplementation on BP by conducting a meta-analysis of randomized, double-blind, placebo-controlled trials.

METHODS

PubMed, Cochrane Central Register of Controlled Trials, and the ClinicalTrials.gov databases were searched through June 2011 to identify randomized, double-blind, placebo-controlled trials of oral L-arginine supplementation on BP in humans. We also reviewed reference lists of obtained articles. Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the combined treatment effect.

RESULTS

We included 11 randomized, double-blind, placebo-controlled trials involving 387 participants with oral L-arginine intervention ranging from 4 to 24 g/d. Compared with placebo, L-arginine intervention significantly lowered systolic BP by 5.39 mm Hg (95% CI -8.54 to -2.25, P = .001) and diastolic BP by 2.66 mm Hg (95% CI -3.77 to -1.54, P < .001). Sensitivity analyses restricted to trials with a duration of 4 weeks or longer and to trials in which participants did not use antihypertensive medications yielded similar results. Meta-regression analysis suggested an inverse, though insignificant (P = .13), relation between baseline systolic BP and net change in systolic BP.

CONCLUSIONS

This meta-analysis provides further evidence that oral L-arginine supplementation significantly lowers both systolic and diastolic BP.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

22137067

Citation

Dong, Jia-Yi, et al. "Effect of Oral L-arginine Supplementation On Blood Pressure: a Meta-analysis of Randomized, Double-blind, Placebo-controlled Trials." American Heart Journal, vol. 162, no. 6, 2011, pp. 959-65.
Dong JY, Qin LQ, Zhang Z, et al. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011;162(6):959-65.
Dong, J. Y., Qin, L. Q., Zhang, Z., Zhao, Y., Wang, J., Arigoni, F., & Zhang, W. (2011). Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. American Heart Journal, 162(6), 959-65. https://doi.org/10.1016/j.ahj.2011.09.012
Dong JY, et al. Effect of Oral L-arginine Supplementation On Blood Pressure: a Meta-analysis of Randomized, Double-blind, Placebo-controlled Trials. Am Heart J. 2011;162(6):959-65. PubMed PMID: 22137067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. AU - Dong,Jia-Yi, AU - Qin,Li-Qiang, AU - Zhang,Zengli, AU - Zhao,Youyou, AU - Wang,Junkuan, AU - Arigoni,Fabrizio, AU - Zhang,Weiguo, Y1 - 2011/11/08/ PY - 2011/06/27/received PY - 2011/09/13/accepted PY - 2011/12/6/entrez PY - 2011/12/6/pubmed PY - 2012/3/2/medline SP - 959 EP - 65 JF - American heart journal JO - Am. Heart J. VL - 162 IS - 6 N2 - BACKGROUND: Previous studies suggest that L-arginine, an amino acid and a substrate of nitric oxide synthase, may have blood pressure (BP)-lowering effect. Because some studies were performed with limited number of patients with hypertension and therefore limited statistical power with sometimes inconsistent results, we aimed to examine the effect of oral L-arginine supplementation on BP by conducting a meta-analysis of randomized, double-blind, placebo-controlled trials. METHODS: PubMed, Cochrane Central Register of Controlled Trials, and the ClinicalTrials.gov databases were searched through June 2011 to identify randomized, double-blind, placebo-controlled trials of oral L-arginine supplementation on BP in humans. We also reviewed reference lists of obtained articles. Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the combined treatment effect. RESULTS: We included 11 randomized, double-blind, placebo-controlled trials involving 387 participants with oral L-arginine intervention ranging from 4 to 24 g/d. Compared with placebo, L-arginine intervention significantly lowered systolic BP by 5.39 mm Hg (95% CI -8.54 to -2.25, P = .001) and diastolic BP by 2.66 mm Hg (95% CI -3.77 to -1.54, P < .001). Sensitivity analyses restricted to trials with a duration of 4 weeks or longer and to trials in which participants did not use antihypertensive medications yielded similar results. Meta-regression analysis suggested an inverse, though insignificant (P = .13), relation between baseline systolic BP and net change in systolic BP. CONCLUSIONS: This meta-analysis provides further evidence that oral L-arginine supplementation significantly lowers both systolic and diastolic BP. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/22137067/Effect_of_oral_L_arginine_supplementation_on_blood_pressure:_a_meta_analysis_of_randomized_double_blind_placebo_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8703(11)00697-1 DB - PRIME DP - Unbound Medicine ER -