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Further improvement of orally disintegrating tablets using micronized ethylcellulose.
Int J Pharm. 2012 Feb 28; 423(2):351-9.IJ

Abstract

The aim of this study is to design a new orally disintegrating tablet (ODT) containing micronized ethylcellulose (MEC). The new ODT was prepared by physical mixing of rapidly disintegrating granules (RDGs) with MEC. To obtain RDGs, mannitol was spray-coated with a suspension of corn starch and crospovidone (9:1, w/w ratio) using a fluidized-bed granulator (suspension spray-coating method). The new ODTs were evaluated for their hardness, friability, thickness, internal structure (X-ray-CT scanning), in vivo disintegration time, and water absorption rate. Since MEC increases tablet hardness by increasing the contact frequency between the granules, the new ODTs could obtain high hardness (>50 N) and low friability (<0.5 %) with relatively low compression force. In addition, fine capillary channels formed in ODTs facilitated the wicking action and enabled rapid disintegration in vivo (<30 s). On the other hand, since MEC has low hygroscopicity, the tablet hardness of ODTs containing MEC remained high for 1 month in high-humidity conditions. In conclusion, the new ODTs containing MEC developed in this study possessed superior properties for clinical use and are expected to be applied for a wide range of functionally released drugs for bitter taste masking, sustained release, and controlled release (pH-dependent film coating, matrix, and microcapsule).

Authors+Show Affiliations

Towa Pharmaceutical Co., Ltd., 26-7 Ichiban-Cho, Kadoma, Osaka 571-0033, Japan. y-okuda@towayakuhin.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22138608

Citation

Okuda, Yutaka, et al. "Further Improvement of Orally Disintegrating Tablets Using Micronized Ethylcellulose." International Journal of Pharmaceutics, vol. 423, no. 2, 2012, pp. 351-9.
Okuda Y, Irisawa Y, Okimoto K, et al. Further improvement of orally disintegrating tablets using micronized ethylcellulose. Int J Pharm. 2012;423(2):351-9.
Okuda, Y., Irisawa, Y., Okimoto, K., Osawa, T., & Yamashita, S. (2012). Further improvement of orally disintegrating tablets using micronized ethylcellulose. International Journal of Pharmaceutics, 423(2), 351-9. https://doi.org/10.1016/j.ijpharm.2011.10.050
Okuda Y, et al. Further Improvement of Orally Disintegrating Tablets Using Micronized Ethylcellulose. Int J Pharm. 2012 Feb 28;423(2):351-9. PubMed PMID: 22138608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further improvement of orally disintegrating tablets using micronized ethylcellulose. AU - Okuda,Yutaka, AU - Irisawa,Yosuke, AU - Okimoto,Kazuto, AU - Osawa,Takashi, AU - Yamashita,Shinji, Y1 - 2011/11/26/ PY - 2011/08/01/received PY - 2011/10/15/revised PY - 2011/10/27/accepted PY - 2011/12/6/entrez PY - 2011/12/6/pubmed PY - 2012/6/16/medline SP - 351 EP - 9 JF - International journal of pharmaceutics JO - Int J Pharm VL - 423 IS - 2 N2 - The aim of this study is to design a new orally disintegrating tablet (ODT) containing micronized ethylcellulose (MEC). The new ODT was prepared by physical mixing of rapidly disintegrating granules (RDGs) with MEC. To obtain RDGs, mannitol was spray-coated with a suspension of corn starch and crospovidone (9:1, w/w ratio) using a fluidized-bed granulator (suspension spray-coating method). The new ODTs were evaluated for their hardness, friability, thickness, internal structure (X-ray-CT scanning), in vivo disintegration time, and water absorption rate. Since MEC increases tablet hardness by increasing the contact frequency between the granules, the new ODTs could obtain high hardness (>50 N) and low friability (<0.5 %) with relatively low compression force. In addition, fine capillary channels formed in ODTs facilitated the wicking action and enabled rapid disintegration in vivo (<30 s). On the other hand, since MEC has low hygroscopicity, the tablet hardness of ODTs containing MEC remained high for 1 month in high-humidity conditions. In conclusion, the new ODTs containing MEC developed in this study possessed superior properties for clinical use and are expected to be applied for a wide range of functionally released drugs for bitter taste masking, sustained release, and controlled release (pH-dependent film coating, matrix, and microcapsule). SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/22138608/Further_improvement_of_orally_disintegrating_tablets_using_micronized_ethylcellulose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(11)01029-5 DB - PRIME DP - Unbound Medicine ER -