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New-onset diabetes patients need pancreatic cancer screening?

Abstract

OBJECTIVE

Because patients with new-onset diabetes mellitus (DM) have a significantly increased likelihood of association with pancreatic cancer, we need to select the subgroup of diabetic patients who have more chance of association with pancreatic cancer.

METHODS

We retrospectively reviewed medical records of case group (151 patients with pancreatic cancer with new-onset DM) and control group (302 patients with new-onset DM without cancer).

RESULTS

Compared with the control group, pancreatic cancer group were older, had more weight loss, lower usual body mass index (BMI), more family history of pancreatic cancer (3.3% vs. 0.7%; P=0.044), and had less family history of DM (13.9% vs. 37.4%; P<0.001). If a new-onset DM patient did not have family history of DM, he was of age older than or equal to 65 years or had weight loss of >2 kg or had premorbid usual BMI <25 kg/m(2), pancreatic cancer associated DM could be discriminated from new-onset type 2 DM with 80.8% sensitivity, 67.6% specificity, 2.5% and 99.7% of positive and negative predictability for pancreatic cancer, respectively.

CONCLUSIONS

Among patients who meet criteria for diabetes within 2 years, those who are elderly, have lower premorbid BMI, weight loss, no family history of DM, need screening of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Division of Gastroenterology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

    , , , , , ,

    Source

    Journal of clinical gastroenterology 46:7 2012 Aug pg e58-61

    MeSH

    Aged
    Case-Control Studies
    Diabetes Complications
    Diabetes Mellitus
    Early Detection of Cancer
    Female
    Humans
    Male
    Middle Aged
    Pancreatic Neoplasms
    Prevalence
    Time Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22138846

    Citation

    Lee, Jin Hee, et al. "New-onset Diabetes Patients Need Pancreatic Cancer Screening?" Journal of Clinical Gastroenterology, vol. 46, no. 7, 2012, pp. e58-61.
    Lee JH, Kim SA, Park HY, et al. New-onset diabetes patients need pancreatic cancer screening? J Clin Gastroenterol. 2012;46(7):e58-61.
    Lee, J. H., Kim, S. A., Park, H. Y., Lee, K. H., Lee, K. T., Lee, J. K., ... Kim, K. W. (2012). New-onset diabetes patients need pancreatic cancer screening? Journal of Clinical Gastroenterology, 46(7), pp. e58-61. doi:10.1097/MCG.0b013e318238348c.
    Lee JH, et al. New-onset Diabetes Patients Need Pancreatic Cancer Screening. J Clin Gastroenterol. 2012;46(7):e58-61. PubMed PMID: 22138846.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - New-onset diabetes patients need pancreatic cancer screening? AU - Lee,Jin Hee, AU - Kim,Su-A, AU - Park,Ho Yong, AU - Lee,Kwang Hyuck, AU - Lee,Kyu Taek, AU - Lee,Jong Kyun, AU - Bae,Ji Cheol, AU - Kim,Kwang Won, PY - 2011/12/6/entrez PY - 2011/12/6/pubmed PY - 2012/12/14/medline SP - e58 EP - 61 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 46 IS - 7 N2 - OBJECTIVE: Because patients with new-onset diabetes mellitus (DM) have a significantly increased likelihood of association with pancreatic cancer, we need to select the subgroup of diabetic patients who have more chance of association with pancreatic cancer. METHODS: We retrospectively reviewed medical records of case group (151 patients with pancreatic cancer with new-onset DM) and control group (302 patients with new-onset DM without cancer). RESULTS: Compared with the control group, pancreatic cancer group were older, had more weight loss, lower usual body mass index (BMI), more family history of pancreatic cancer (3.3% vs. 0.7%; P=0.044), and had less family history of DM (13.9% vs. 37.4%; P<0.001). If a new-onset DM patient did not have family history of DM, he was of age older than or equal to 65 years or had weight loss of >2 kg or had premorbid usual BMI <25 kg/m(2), pancreatic cancer associated DM could be discriminated from new-onset type 2 DM with 80.8% sensitivity, 67.6% specificity, 2.5% and 99.7% of positive and negative predictability for pancreatic cancer, respectively. CONCLUSIONS: Among patients who meet criteria for diabetes within 2 years, those who are elderly, have lower premorbid BMI, weight loss, no family history of DM, need screening of pancreatic cancer. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/22138846/New_onset_diabetes_patients_need_pancreatic_cancer_screening L2 - http://Insights.ovid.com/pubmed?pmid=22138846 DB - PRIME DP - Unbound Medicine ER -