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Glomerular hyperfiltration in prediabetes and prehypertension.
Nephrol Dial Transplant 2012; 27(5):1821-5ND

Abstract

BACKGROUND

This study aimed to investigate the associations of hyperfiltration and hypofiltration with prediabetes and prehypertension.

METHODS

The study subjects included 99 140 people aged 20-89 years who underwent health checkups in Aichi Prefecture, Japan. The prevalence of hyperfiltration [estimated glomerular filtration rate (eGFR) above the age-/sex-specific 95th percentile] and hypofiltration (eGFR below the age-/sex-specific 5th percentile) was compared among stages of prediabetes (fasting plasma glucose <100, 100-109, 110-125 and ≥126 mg/dL for no prediabetes, Stage 1 prediabetes, Stage 2 prediabetes and diabetes, respectively) and prehypertension [blood pressure (BP) <120/80, 120-129/80-84, 130-139/85-89 and ≥140/90 mmHg for no prehypertension, Stage 1 prehypertension, Stage 2 prehypertension and hypertension, respectively).

RESULTS

The prevalence of hyperfiltration increased with increasing stage of prediabetes [odds ratios (ORs): 1.29, 1.58 and 2.47 for Stage 1 prediabetes, Stage 2 prediabetes and diabetes, respectively] and prehypertension (ORs: 1.10, 1.33 and 1.52 for Stage 1 prehypertension, Stage 2 prehypertension and hypertension, respectively). Hypofiltration was not associated with prediabetes or prehypertension.

CONCLUSIONS

The prevalence of glomerular hyperfiltration increased with increasing stages of prediabetes and prehypertension. Therefore, kidney function should be monitored in subjects with prediabetes or prehypertension. In subjects with hyperfiltration, earlier treatment of hyperglycemia and high BP may be necessary to prevent the development of kidney damage.

Authors+Show Affiliations

Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. rieokada@med.nagoya-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22140135

Citation

Okada, Rieko, et al. "Glomerular Hyperfiltration in Prediabetes and Prehypertension." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 27, no. 5, 2012, pp. 1821-5.
Okada R, Yasuda Y, Tsushita K, et al. Glomerular hyperfiltration in prediabetes and prehypertension. Nephrol Dial Transplant. 2012;27(5):1821-5.
Okada, R., Yasuda, Y., Tsushita, K., Wakai, K., Hamajima, N., & Matsuo, S. (2012). Glomerular hyperfiltration in prediabetes and prehypertension. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 27(5), pp. 1821-5. doi:10.1093/ndt/gfr651.
Okada R, et al. Glomerular Hyperfiltration in Prediabetes and Prehypertension. Nephrol Dial Transplant. 2012;27(5):1821-5. PubMed PMID: 22140135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glomerular hyperfiltration in prediabetes and prehypertension. AU - Okada,Rieko, AU - Yasuda,Yoshinari, AU - Tsushita,Kazuyo, AU - Wakai,Kenji, AU - Hamajima,Nobuyuki, AU - Matsuo,Seiichi, Y1 - 2011/12/02/ PY - 2011/12/6/entrez PY - 2011/12/6/pubmed PY - 2012/12/12/medline SP - 1821 EP - 5 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol. Dial. Transplant. VL - 27 IS - 5 N2 - BACKGROUND: This study aimed to investigate the associations of hyperfiltration and hypofiltration with prediabetes and prehypertension. METHODS: The study subjects included 99 140 people aged 20-89 years who underwent health checkups in Aichi Prefecture, Japan. The prevalence of hyperfiltration [estimated glomerular filtration rate (eGFR) above the age-/sex-specific 95th percentile] and hypofiltration (eGFR below the age-/sex-specific 5th percentile) was compared among stages of prediabetes (fasting plasma glucose <100, 100-109, 110-125 and ≥126 mg/dL for no prediabetes, Stage 1 prediabetes, Stage 2 prediabetes and diabetes, respectively) and prehypertension [blood pressure (BP) <120/80, 120-129/80-84, 130-139/85-89 and ≥140/90 mmHg for no prehypertension, Stage 1 prehypertension, Stage 2 prehypertension and hypertension, respectively). RESULTS: The prevalence of hyperfiltration increased with increasing stage of prediabetes [odds ratios (ORs): 1.29, 1.58 and 2.47 for Stage 1 prediabetes, Stage 2 prediabetes and diabetes, respectively] and prehypertension (ORs: 1.10, 1.33 and 1.52 for Stage 1 prehypertension, Stage 2 prehypertension and hypertension, respectively). Hypofiltration was not associated with prediabetes or prehypertension. CONCLUSIONS: The prevalence of glomerular hyperfiltration increased with increasing stages of prediabetes and prehypertension. Therefore, kidney function should be monitored in subjects with prediabetes or prehypertension. In subjects with hyperfiltration, earlier treatment of hyperglycemia and high BP may be necessary to prevent the development of kidney damage. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/22140135/Glomerular_hyperfiltration_in_prediabetes_and_prehypertension_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfr651 DB - PRIME DP - Unbound Medicine ER -