Tags

Type your tag names separated by a space and hit enter

The role of mast cells on angiogenesis in oral squamous cell carcinoma.
Med Oral Patol Oral Cir Bucal. 2012 Mar 01; 17(2):e190-6.MO

Abstract

OBJECTIVE

Angiogenesis or neovascularization has long been known to aid in progression and metastasis of malignant tumors. Tumor angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and or by host immune cells. Mast cells may induce tumor progression and potentiate metastasis by stimulating angiogenesis. The purpose of the present study was to validate topographic distribution of micro vessel density (MVD) and mast cell density (MCD) and help to elucidate the possible role of mast cells in tumor angiogenesis and correlating this with advanced disease parameters. .

STUDY DESIGN

MVD and MCD were investigated in tumor specimens from 30 patients diagnosed with different histologic grades of oral squamous cell carcinoma (OSCC). Intratumor vessels were stained with collagen Type IV antibody and mast cells with Toluidine blue before being measured by light microscopy.

RESULTS

There was a significant correlation between MVD and disease progression and number of blood vessels increased from well to poorly differentiated OSCC where as MCD decreased.

CONCLUSIONS

These findings suggest that angiogenesis indeed occur in OSCC and might be used as an index to inflect the aggression of the disease however mast cells make up only a part of complex process of angiogenesis along with other factors secreted by tumor.

Authors+Show Affiliations

Department of Oral Pathology and Microbiology, SGT Dental College and Hospital Gurgaon, India. drmanpreetkalra@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22143687

Citation

Kalra, M, et al. "The Role of Mast Cells On Angiogenesis in Oral Squamous Cell Carcinoma." Medicina Oral, Patologia Oral Y Cirugia Bucal, vol. 17, no. 2, 2012, pp. e190-6.
Kalra M, Rao N, Nanda K, et al. The role of mast cells on angiogenesis in oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2012;17(2):e190-6.
Kalra, M., Rao, N., Nanda, K., Rehman, F., Girish, K. L., Tippu, S., & Arora, A. (2012). The role of mast cells on angiogenesis in oral squamous cell carcinoma. Medicina Oral, Patologia Oral Y Cirugia Bucal, 17(2), e190-6.
Kalra M, et al. The Role of Mast Cells On Angiogenesis in Oral Squamous Cell Carcinoma. Med Oral Patol Oral Cir Bucal. 2012 Mar 1;17(2):e190-6. PubMed PMID: 22143687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of mast cells on angiogenesis in oral squamous cell carcinoma. AU - Kalra,M, AU - Rao,N, AU - Nanda,K, AU - Rehman,F, AU - Girish,K-L, AU - Tippu,S, AU - Arora,A, Y1 - 2012/03/01/ PY - 2010/11/12/received PY - 2011/04/12/accepted PY - 2011/12/7/entrez PY - 2011/12/7/pubmed PY - 2012/7/27/medline SP - e190 EP - 6 JF - Medicina oral, patologia oral y cirugia bucal JO - Med Oral Patol Oral Cir Bucal VL - 17 IS - 2 N2 - OBJECTIVE: Angiogenesis or neovascularization has long been known to aid in progression and metastasis of malignant tumors. Tumor angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and or by host immune cells. Mast cells may induce tumor progression and potentiate metastasis by stimulating angiogenesis. The purpose of the present study was to validate topographic distribution of micro vessel density (MVD) and mast cell density (MCD) and help to elucidate the possible role of mast cells in tumor angiogenesis and correlating this with advanced disease parameters. . STUDY DESIGN: MVD and MCD were investigated in tumor specimens from 30 patients diagnosed with different histologic grades of oral squamous cell carcinoma (OSCC). Intratumor vessels were stained with collagen Type IV antibody and mast cells with Toluidine blue before being measured by light microscopy. RESULTS: There was a significant correlation between MVD and disease progression and number of blood vessels increased from well to poorly differentiated OSCC where as MCD decreased. CONCLUSIONS: These findings suggest that angiogenesis indeed occur in OSCC and might be used as an index to inflect the aggression of the disease however mast cells make up only a part of complex process of angiogenesis along with other factors secreted by tumor. SN - 1698-6946 UR - https://www.unboundmedicine.com/medline/citation/22143687/The_role_of_mast_cells_on_angiogenesis_in_oral_squamous_cell_carcinoma_ L2 - http://www.medicinaoral.com/pubmed/medoralv17_i2_p190.pdf DB - PRIME DP - Unbound Medicine ER -