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Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents.
Endokrynol Pol. 2011; 62(6):506-11.EP

Abstract

BACKGROUND

There is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease. The influences of gender, puberty, and adiposity on serum hydroxyvitamin D (25-OH-D) levels and the relationship between 25-OH-D and insulin resistance in obese children were studied.

MATERIAL AND METHODS

Age, gender, pubertal stage, weight status (standard deviation score of body mass index: BMI-SDS, percentage body fat, waist circumference), 25-OH-D levels, and insulin resistance index calculated by homeostasis model assessment (HOMA-IR) were evaluated in 64 obese adolescents. Multivariable linear regression was used to determine factors associated with decreased serum 25-OH-D levels and to study the relationship between 25-OH-D and HOMA-IR.

RESULTS

Median serum 25-OH-D level was 10.1 ng/mL (25.2 nmol/L). 14% of patients were vitamin D-sufficient (25-OH-D ≥ 20 ng/mL), 36% had intermediate values (11-19 ng/mL), and 50% were deficient (25-OH-D ≤ 10 ng/mL). In the multivariable model, older age, puberty, higher value of percentage of body fat, and the presence of acanthosis nigricans (AN) were all negatively associated with 25-OH-D. Lower 25-OH-D levels were also associated with higher blood glucose, insulin and HOMA-IR after adjustment for puberty and SDS-BMI. Summer positively correlated with 25-OH-D level.

CONCLUSION

Our study confirms that obesity is a risk factor for vitamin D deficiency. Hypovitaminosis D, common in obese adolescents at risk for type 2 diabetes (older age, puberty, acanthosis nigricans) is associated with worse insulin resistance.

Authors+Show Affiliations

Independent Laboratory of Propaedeutics of Children’s Diseases, Pomeranian Medical University, Szczecin, Poland. propedeutyka1@wp.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22144216

Citation

Garanty-Bogacka, Barbara, et al. "Serum 25-hydroxyvitamin D (25-OH-D) in Obese Adolescents." Endokrynologia Polska, vol. 62, no. 6, 2011, pp. 506-11.
Garanty-Bogacka B, Syrenicz M, Goral J, et al. Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents. Endokrynol Pol. 2011;62(6):506-11.
Garanty-Bogacka, B., Syrenicz, M., Goral, J., Krupa, B., Syrenicz, J., Walczak, M., & Syrenicz, A. (2011). Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents. Endokrynologia Polska, 62(6), 506-11.
Garanty-Bogacka B, et al. Serum 25-hydroxyvitamin D (25-OH-D) in Obese Adolescents. Endokrynol Pol. 2011;62(6):506-11. PubMed PMID: 22144216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents. AU - Garanty-Bogacka,Barbara, AU - Syrenicz,Małgorzata, AU - Goral,Joanna, AU - Krupa,Beata, AU - Syrenicz,Justyna, AU - Walczak,Mieczysław, AU - Syrenicz,Anhelli, PY - 2011/12/7/entrez PY - 2011/12/7/pubmed PY - 2012/4/27/medline SP - 506 EP - 11 JF - Endokrynologia Polska JO - Endokrynol Pol VL - 62 IS - 6 N2 - BACKGROUND: There is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease. The influences of gender, puberty, and adiposity on serum hydroxyvitamin D (25-OH-D) levels and the relationship between 25-OH-D and insulin resistance in obese children were studied. MATERIAL AND METHODS: Age, gender, pubertal stage, weight status (standard deviation score of body mass index: BMI-SDS, percentage body fat, waist circumference), 25-OH-D levels, and insulin resistance index calculated by homeostasis model assessment (HOMA-IR) were evaluated in 64 obese adolescents. Multivariable linear regression was used to determine factors associated with decreased serum 25-OH-D levels and to study the relationship between 25-OH-D and HOMA-IR. RESULTS: Median serum 25-OH-D level was 10.1 ng/mL (25.2 nmol/L). 14% of patients were vitamin D-sufficient (25-OH-D ≥ 20 ng/mL), 36% had intermediate values (11-19 ng/mL), and 50% were deficient (25-OH-D ≤ 10 ng/mL). In the multivariable model, older age, puberty, higher value of percentage of body fat, and the presence of acanthosis nigricans (AN) were all negatively associated with 25-OH-D. Lower 25-OH-D levels were also associated with higher blood glucose, insulin and HOMA-IR after adjustment for puberty and SDS-BMI. Summer positively correlated with 25-OH-D level. CONCLUSION: Our study confirms that obesity is a risk factor for vitamin D deficiency. Hypovitaminosis D, common in obese adolescents at risk for type 2 diabetes (older age, puberty, acanthosis nigricans) is associated with worse insulin resistance. SN - 2299-8306 UR - https://www.unboundmedicine.com/medline/citation/22144216/Serum_25_hydroxyvitamin_D__25_OH_D__in_obese_adolescents_ L2 - http://www.endokrynologia.polska.viamedica.pl/en/zamow_art_pdf.phtml?id=49&indeks_art=666 DB - PRIME DP - Unbound Medicine ER -