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Review: Malaria chemoprophylaxis for travelers to Latin America.
Am J Trop Med Hyg. 2011 Dec; 85(6):1015-24.AJ

Abstract

Because of recent declining malaria transmission in Latin America, some authorities have recommended against chemoprophylaxis for most travelers to this region. However, the predominant parasite species in Latin America, Plasmodium vivax, can form hypnozoites sequestered in the liver, causing malaria relapses. Additionally, new evidence shows the potential severity of vivax infections, warranting continued consideration of prophylaxis for travel to Latin America. Individualized travel risk assessments are recommended and should consider travel locations, type, length, and season, as well as probability of itinerary changes. Travel recommendations might include no precautions, mosquito avoidance only, or mosquito avoidance and chemoprophylaxis. There are a range of good options for chemoprophylaxis in Latin America, including atovaquone-proguanil, doxycycline, mefloquine, and--in selected areas--chloroquine. Primaquine should be strongly considered for nonpregnant, G6PD-nondeficient patients traveling to vivax-endemic areas of Latin America, and it has the added benefit of being the only drug to protect against malaria relapses.

Authors+Show Affiliations

Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Prevention and Control, Atlanta, Georgia 30333, USA. LSteinhardt@cdc.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22144437

Citation

Steinhardt, Laura C., et al. "Review: Malaria Chemoprophylaxis for Travelers to Latin America." The American Journal of Tropical Medicine and Hygiene, vol. 85, no. 6, 2011, pp. 1015-24.
Steinhardt LC, Magill AJ, Arguin PM. Review: Malaria chemoprophylaxis for travelers to Latin America. Am J Trop Med Hyg. 2011;85(6):1015-24.
Steinhardt, L. C., Magill, A. J., & Arguin, P. M. (2011). Review: Malaria chemoprophylaxis for travelers to Latin America. The American Journal of Tropical Medicine and Hygiene, 85(6), 1015-24. https://doi.org/10.4269/ajtmh.2011.11-0464
Steinhardt LC, Magill AJ, Arguin PM. Review: Malaria Chemoprophylaxis for Travelers to Latin America. Am J Trop Med Hyg. 2011;85(6):1015-24. PubMed PMID: 22144437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review: Malaria chemoprophylaxis for travelers to Latin America. AU - Steinhardt,Laura C, AU - Magill,Alan J, AU - Arguin,Paul M, PY - 2011/12/7/entrez PY - 2011/12/7/pubmed PY - 2012/2/2/medline SP - 1015 EP - 24 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 85 IS - 6 N2 - Because of recent declining malaria transmission in Latin America, some authorities have recommended against chemoprophylaxis for most travelers to this region. However, the predominant parasite species in Latin America, Plasmodium vivax, can form hypnozoites sequestered in the liver, causing malaria relapses. Additionally, new evidence shows the potential severity of vivax infections, warranting continued consideration of prophylaxis for travel to Latin America. Individualized travel risk assessments are recommended and should consider travel locations, type, length, and season, as well as probability of itinerary changes. Travel recommendations might include no precautions, mosquito avoidance only, or mosquito avoidance and chemoprophylaxis. There are a range of good options for chemoprophylaxis in Latin America, including atovaquone-proguanil, doxycycline, mefloquine, and--in selected areas--chloroquine. Primaquine should be strongly considered for nonpregnant, G6PD-nondeficient patients traveling to vivax-endemic areas of Latin America, and it has the added benefit of being the only drug to protect against malaria relapses. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/22144437/full_citation L2 - http://www.ajtmh.org/content/journals/10.4269/ajtmh.2011.11-0464?crawler=true&mimetype=application/pdf DB - PRIME DP - Unbound Medicine ER -