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The relationship between serum magnesium levels with childhood obesity and insulin resistance: a review of the literature.
J Pediatr Endocrinol Metab 2011; 24(9-10):675-8JP

Abstract

BACKGROUND

Magnesium, the second most abundant intracellular cation, plays a major role in regulating insulin effect and insulin mediated glucose uptake. It has been shown that serum magnesium levels were negatively correlated with HOMA-IR (homeostasis model of insulin resistance) index.

AIM

To investigate the relationship between serum magnesium levels with obesity and insulin resistance in childhood.

METHODS

Two hundred and three children and adolescents (117 obese children and 86 controls) were included. Obese cases were also subgrouped according to the presence or absence of insulin resistance (IR) as "IR (+) obese" and "IR (-) obese", respectively. Serum glucose, insulin and magnesium levels were measured after a 12-h fasting at 8-8.30 a.m. We assessed insulin sensitivity by using HOMA-IR index as a surrogate marker of insulin resistance.

RESULTS

Serum levels of magnesium were significantly lower in the IR (+) obese group than controls (p = 0.014). At the same time, there was a positive correlation between serum magnesium levels and body mass index-standard deviation score (BMI-SDS) (r = -0.28, p = 0.03) in the IR (-) obese group.

CONCLUSIONS

Low serum magnesium levels may contribute to the development of insulin resistance in obese children.

Authors+Show Affiliations

Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Fatih University, Ankara, Turkey. celiknurullah@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22145455

Citation

Celik, Nurullah, et al. "The Relationship Between Serum Magnesium Levels With Childhood Obesity and Insulin Resistance: a Review of the Literature." Journal of Pediatric Endocrinology & Metabolism : JPEM, vol. 24, no. 9-10, 2011, pp. 675-8.
Celik N, Andiran N, Yilmaz AE. The relationship between serum magnesium levels with childhood obesity and insulin resistance: a review of the literature. J Pediatr Endocrinol Metab. 2011;24(9-10):675-8.
Celik, N., Andiran, N., & Yilmaz, A. E. (2011). The relationship between serum magnesium levels with childhood obesity and insulin resistance: a review of the literature. Journal of Pediatric Endocrinology & Metabolism : JPEM, 24(9-10), pp. 675-8.
Celik N, Andiran N, Yilmaz AE. The Relationship Between Serum Magnesium Levels With Childhood Obesity and Insulin Resistance: a Review of the Literature. J Pediatr Endocrinol Metab. 2011;24(9-10):675-8. PubMed PMID: 22145455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between serum magnesium levels with childhood obesity and insulin resistance: a review of the literature. AU - Celik,Nurullah, AU - Andiran,Nesibe, AU - Yilmaz,Ayse Esra, PY - 2011/12/8/entrez PY - 2011/12/8/pubmed PY - 2012/1/5/medline SP - 675 EP - 8 JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J. Pediatr. Endocrinol. Metab. VL - 24 IS - 9-10 N2 - BACKGROUND: Magnesium, the second most abundant intracellular cation, plays a major role in regulating insulin effect and insulin mediated glucose uptake. It has been shown that serum magnesium levels were negatively correlated with HOMA-IR (homeostasis model of insulin resistance) index. AIM: To investigate the relationship between serum magnesium levels with obesity and insulin resistance in childhood. METHODS: Two hundred and three children and adolescents (117 obese children and 86 controls) were included. Obese cases were also subgrouped according to the presence or absence of insulin resistance (IR) as "IR (+) obese" and "IR (-) obese", respectively. Serum glucose, insulin and magnesium levels were measured after a 12-h fasting at 8-8.30 a.m. We assessed insulin sensitivity by using HOMA-IR index as a surrogate marker of insulin resistance. RESULTS: Serum levels of magnesium were significantly lower in the IR (+) obese group than controls (p = 0.014). At the same time, there was a positive correlation between serum magnesium levels and body mass index-standard deviation score (BMI-SDS) (r = -0.28, p = 0.03) in the IR (-) obese group. CONCLUSIONS: Low serum magnesium levels may contribute to the development of insulin resistance in obese children. SN - 0334-018X UR - https://www.unboundmedicine.com/medline/citation/22145455/The_relationship_between_serum_magnesium_levels_with_childhood_obesity_and_insulin_resistance:_a_review_of_the_literature_ L2 - http://www.diseaseinfosearch.org/result/9028 DB - PRIME DP - Unbound Medicine ER -