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Acantholytic Anaplastic Extramammary Paget's Disease: A Case Report and Review of the Literature.
Ann Dermatol 2011; 23(Suppl 2):S226-30AD

Abstract

Extramammary Paget's disease (EMPD) is an uncommon intraepithelial neoplasm that most commonly arises on the vulva and perianal region. Very few cases of EMPD revealing a histological Bowenoid appearance have been reported. This study describes scrotal EMPD presenting with histological features of Bowen's disease in a 79-year-old man. He presented with a 5-year history of a pruritic erythematous plaque and a verrucous papule on the scrotum. The verrucous papule histopathologically showed Bowenoid features, and the erythematous plaque demonstrated acantholytic EMPD. Immunohistochemical findings revealed strong expression for carcinoembryonic antigen, Cam 5.2, epithelial membrane antigen, cytokeratin (CK) 7, and pancytokeratin (AE1/AE3) in both areas, but negative CK20 staining, supporting the overall diagnosis of primary acantholytic anaplastic EMPD. This is the first reported case of acantholytic anaplastic EMPD in the Korean literature.

Authors+Show Affiliations

Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports

Language

eng

PubMed ID

22148057

Citation

Oh, Yu-Jin, et al. "Acantholytic Anaplastic Extramammary Paget's Disease: a Case Report and Review of the Literature." Annals of Dermatology, vol. 23, no. Suppl 2, 2011, pp. S226-30.
Oh YJ, Lew BL, Sim WY. Acantholytic Anaplastic Extramammary Paget's Disease: A Case Report and Review of the Literature. Ann Dermatol. 2011;23(Suppl 2):S226-30.
Oh, Y. J., Lew, B. L., & Sim, W. Y. (2011). Acantholytic Anaplastic Extramammary Paget's Disease: A Case Report and Review of the Literature. Annals of Dermatology, 23(Suppl 2), pp. S226-30. doi:10.5021/ad.2011.23.S2.S226.
Oh YJ, Lew BL, Sim WY. Acantholytic Anaplastic Extramammary Paget's Disease: a Case Report and Review of the Literature. Ann Dermatol. 2011;23(Suppl 2):S226-30. PubMed PMID: 22148057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acantholytic Anaplastic Extramammary Paget's Disease: A Case Report and Review of the Literature. AU - Oh,Yu-Jin, AU - Lew,Bark-Lynn, AU - Sim,Woo-Young, Y1 - 2011/10/31/ PY - 2011/04/05/received PY - 2011/06/07/revised PY - 2011/06/14/accepted PY - 2011/12/8/entrez PY - 2011/12/8/pubmed PY - 2011/12/8/medline KW - Acantholytic KW - Anaplastic KW - Bowenoid KW - Extramammary Paget disease KW - Immunohistochemistry SP - S226 EP - 30 JF - Annals of dermatology JO - Ann Dermatol VL - 23 IS - Suppl 2 N2 - Extramammary Paget's disease (EMPD) is an uncommon intraepithelial neoplasm that most commonly arises on the vulva and perianal region. Very few cases of EMPD revealing a histological Bowenoid appearance have been reported. This study describes scrotal EMPD presenting with histological features of Bowen's disease in a 79-year-old man. He presented with a 5-year history of a pruritic erythematous plaque and a verrucous papule on the scrotum. The verrucous papule histopathologically showed Bowenoid features, and the erythematous plaque demonstrated acantholytic EMPD. Immunohistochemical findings revealed strong expression for carcinoembryonic antigen, Cam 5.2, epithelial membrane antigen, cytokeratin (CK) 7, and pancytokeratin (AE1/AE3) in both areas, but negative CK20 staining, supporting the overall diagnosis of primary acantholytic anaplastic EMPD. This is the first reported case of acantholytic anaplastic EMPD in the Korean literature. SN - 2005-3894 UR - https://www.unboundmedicine.com/medline/citation/22148057/Acantholytic_Anaplastic_Extramammary_Paget's_Disease:_A_Case_Report_and_Review_of_the_Literature_ L2 - https://anndermatol.org/DOIx.php?id=10.5021/ad.2011.23.S2.S226 DB - PRIME DP - Unbound Medicine ER -