Tags

Type your tag names separated by a space and hit enter

Estimating glomerular filtration rate in hypertensive subjects: comparison of the chronic kidney disease epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) study equations.
Ann Med. 2012 Aug; 44(5):487-93.AM

Abstract

BACKGROUND

The Modification of Diet in Renal Disease (MDRD) Study equation is the most commonly used formula for estimation of glomerular filtration rate (eGFR). Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) developed a new equation to provide a more accurate estimate of GFR among individuals with normal or mildly reduced renal function.

AIM

To compare the MDRD and CKD-EPI equations in hypertensive population treated in general practice.

METHODS

The MDRD and CKD-EPI equations were applied to a cohort of 994 hypertensive subjects aged 45-70 years without cardiovascular or renal disease or previously known diabetes.

RESULTS

The prevalence of CKD stage 3 (eGFR 30-59 mL/min per 1.73 m(2)) was 6.7% (95% CI 5.3-8.5) (67/994) according to the MDRD formula and 3.7% (95% CI 2.6-5.1) (37/994) according to the CKD-EPI formula. Of the 67 subjects classified as having CKD stage 3 according to the MDRD equation, 30 (44.8%) were reclassified as 'no-CKD' by the CKD-EPI equation. These subjects were mostly women 26/30 (87.7%).

CONCLUSION

Using the CKD-EPI equation leads to lower prevalence estimates for CKD than the MDRD equation in a hypertensive population treated in general practice.

Authors+Show Affiliations

Central Satakunta Health Federation of Municipalities, Harjavalta, Finland. paivi.e.korhonen@fi mnet.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22149718

Citation

Korhonen, Päivi E., et al. "Estimating Glomerular Filtration Rate in Hypertensive Subjects: Comparison of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study Equations." Annals of Medicine, vol. 44, no. 5, 2012, pp. 487-93.
Korhonen PE, Kivelä SL, Aarnio PT, et al. Estimating glomerular filtration rate in hypertensive subjects: comparison of the chronic kidney disease epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) study equations. Ann Med. 2012;44(5):487-93.
Korhonen, P. E., Kivelä, S. L., Aarnio, P. T., Kautiainen, H., Järvenpää, S., & Kantola, I. M. (2012). Estimating glomerular filtration rate in hypertensive subjects: comparison of the chronic kidney disease epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) study equations. Annals of Medicine, 44(5), 487-93. https://doi.org/10.3109/07853890.2011.580775
Korhonen PE, et al. Estimating Glomerular Filtration Rate in Hypertensive Subjects: Comparison of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study Equations. Ann Med. 2012;44(5):487-93. PubMed PMID: 22149718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimating glomerular filtration rate in hypertensive subjects: comparison of the chronic kidney disease epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) study equations. AU - Korhonen,Päivi E, AU - Kivelä,Sirkka-Liisa, AU - Aarnio,Pertti T, AU - Kautiainen,Hannu, AU - Järvenpää,Salme, AU - Kantola,Ilkka M, Y1 - 2011/12/12/ PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/11/14/medline SP - 487 EP - 93 JF - Annals of medicine JO - Ann Med VL - 44 IS - 5 N2 - BACKGROUND: The Modification of Diet in Renal Disease (MDRD) Study equation is the most commonly used formula for estimation of glomerular filtration rate (eGFR). Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) developed a new equation to provide a more accurate estimate of GFR among individuals with normal or mildly reduced renal function. AIM: To compare the MDRD and CKD-EPI equations in hypertensive population treated in general practice. METHODS: The MDRD and CKD-EPI equations were applied to a cohort of 994 hypertensive subjects aged 45-70 years without cardiovascular or renal disease or previously known diabetes. RESULTS: The prevalence of CKD stage 3 (eGFR 30-59 mL/min per 1.73 m(2)) was 6.7% (95% CI 5.3-8.5) (67/994) according to the MDRD formula and 3.7% (95% CI 2.6-5.1) (37/994) according to the CKD-EPI formula. Of the 67 subjects classified as having CKD stage 3 according to the MDRD equation, 30 (44.8%) were reclassified as 'no-CKD' by the CKD-EPI equation. These subjects were mostly women 26/30 (87.7%). CONCLUSION: Using the CKD-EPI equation leads to lower prevalence estimates for CKD than the MDRD equation in a hypertensive population treated in general practice. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/22149718/Estimating_glomerular_filtration_rate_in_hypertensive_subjects:_comparison_of_the_chronic_kidney_disease_epidemiology_collaboration__CKD_EPI__and_modification_of_diet_in_renal_disease__MDRD__study_equations_ DB - PRIME DP - Unbound Medicine ER -