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Relative importance of different lipid risk factors for the development of myocardial infarction at a very young age (≤ 40 years of age).
Eur J Clin Invest. 2012 Jun; 42(6):631-6.EJ

Abstract

BACKGROUND

Low-density lipoprotein (LDL) cholesterol lowering has been established as one of the principal targets in preventive cardiology. Recently, assessment of LDL particle size and number as well as other lipid moieties has been presented as a more reliable method to quantify atherogenicity of the lipoprotein fractions. Thus, it was our aim to assess the influence of different lipoprotein fractions on premature myocardial infarction (≤ 40 years of age).

METHODS AND RESULTS

We enrolled 302 patients into our multicentre case-control study, including 102 patients with myocardial infarction and 200 age-, gender- and centre-matched controls. The LDL and HDL Lipoprint System were used for lipid subfraction quantification. The lipid risk factors most strongly associated with premature acute myocardial infarction (AMI) in the adjusted model were non-HDL C (OR 5·02, 95% CI 2·75-9·15, P-value = 0·001), LDL-C (OR 4·35, 95% CI 2·5-7·57, P-value = 0·001), VLDL-C (OR 3·66, 95% CI 2·14-6·28, P-value = 0·001), large IDL-C (OR 3·15, 95% CI 1·94-5·12, P-value = 0·001), large LDL-C (OR 3·67, 95% CI 2·19-6·15, P-value = 0·001) and intermediate LDL-C (OR 1·96, 95% CI 1·25-3·06, P-value = 0·003). In contrast, small dense LDL was not significantly associated with premature myocardial infarction.

CONCLUSION

Non-HDL cholesterol is most strongly associated with premature coronary artery disease and could serve as preferred risk predictor and therapeutic target in this young patient population (≤ 40 years). Besides, VLDL, LDL-C, large LDL, intermediate LDL and large IDL were significantly associated with premature myocardial infarction. Furthermore, our data suggest that risk prediction using small dense LDL particles might not be useful in young AMI survivors.

Authors+Show Affiliations

Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22150092

Citation

Goliasch, Georg, et al. "Relative Importance of Different Lipid Risk Factors for the Development of Myocardial Infarction at a Very Young Age (≤ 40 Years of Age)." European Journal of Clinical Investigation, vol. 42, no. 6, 2012, pp. 631-6.
Goliasch G, Oravec S, Blessberger H, et al. Relative importance of different lipid risk factors for the development of myocardial infarction at a very young age (≤ 40 years of age). Eur J Clin Invest. 2012;42(6):631-6.
Goliasch, G., Oravec, S., Blessberger, H., Dostal, E., Hoke, M., Wojta, J., Schillinger, M., Huber, K., Maurer, G., & Wiesbauer, F. (2012). Relative importance of different lipid risk factors for the development of myocardial infarction at a very young age (≤ 40 years of age). European Journal of Clinical Investigation, 42(6), 631-6. https://doi.org/10.1111/j.1365-2362.2011.02629.x
Goliasch G, et al. Relative Importance of Different Lipid Risk Factors for the Development of Myocardial Infarction at a Very Young Age (≤ 40 Years of Age). Eur J Clin Invest. 2012;42(6):631-6. PubMed PMID: 22150092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relative importance of different lipid risk factors for the development of myocardial infarction at a very young age (≤ 40 years of age). AU - Goliasch,Georg, AU - Oravec,Stanislav, AU - Blessberger,Hermann, AU - Dostal,Elisabeth, AU - Hoke,Matthias, AU - Wojta,Johann, AU - Schillinger,Martin, AU - Huber,Kurt, AU - Maurer,Gerald, AU - Wiesbauer,Franz, Y1 - 2011/12/08/ PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/9/28/medline SP - 631 EP - 6 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 42 IS - 6 N2 - BACKGROUND: Low-density lipoprotein (LDL) cholesterol lowering has been established as one of the principal targets in preventive cardiology. Recently, assessment of LDL particle size and number as well as other lipid moieties has been presented as a more reliable method to quantify atherogenicity of the lipoprotein fractions. Thus, it was our aim to assess the influence of different lipoprotein fractions on premature myocardial infarction (≤ 40 years of age). METHODS AND RESULTS: We enrolled 302 patients into our multicentre case-control study, including 102 patients with myocardial infarction and 200 age-, gender- and centre-matched controls. The LDL and HDL Lipoprint System were used for lipid subfraction quantification. The lipid risk factors most strongly associated with premature acute myocardial infarction (AMI) in the adjusted model were non-HDL C (OR 5·02, 95% CI 2·75-9·15, P-value = 0·001), LDL-C (OR 4·35, 95% CI 2·5-7·57, P-value = 0·001), VLDL-C (OR 3·66, 95% CI 2·14-6·28, P-value = 0·001), large IDL-C (OR 3·15, 95% CI 1·94-5·12, P-value = 0·001), large LDL-C (OR 3·67, 95% CI 2·19-6·15, P-value = 0·001) and intermediate LDL-C (OR 1·96, 95% CI 1·25-3·06, P-value = 0·003). In contrast, small dense LDL was not significantly associated with premature myocardial infarction. CONCLUSION: Non-HDL cholesterol is most strongly associated with premature coronary artery disease and could serve as preferred risk predictor and therapeutic target in this young patient population (≤ 40 years). Besides, VLDL, LDL-C, large LDL, intermediate LDL and large IDL were significantly associated with premature myocardial infarction. Furthermore, our data suggest that risk prediction using small dense LDL particles might not be useful in young AMI survivors. SN - 1365-2362 UR - https://www.unboundmedicine.com/medline/citation/22150092/Relative_importance_of_different_lipid_risk_factors_for_the_development_of_myocardial_infarction_at_a_very_young_age__≤_40_years_of_age__ L2 - https://doi.org/10.1111/j.1365-2362.2011.02629.x DB - PRIME DP - Unbound Medicine ER -