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Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis.
Curr Drug Abuse Rev. 2012 Mar; 5(1):32-40.CD

Abstract

AIM

The objective of this meta-analysis is to assess the data regarding changes in herbal cannabis potency over time (from 1970 to 2009).

METHODS

Systematic searches of 17 electronic scientific databases identified studies on this topic, within which 21 case series studies satisfied our inclusion criteria of reporting the mean tetrahydrocannabinol (THC) value per number of samples per year. No language, publication date, publication type or status restrictions were imposed. The study selection and data extraction processes were performed independently but uniformly by two authors, included screening, determination of eligibility and inclusion of the eligible studies in the systematic review, and a meta-analysis of the results on THC content in herbal cannabis samples. We considered papers and not monographic scientific publications, rejecting all studies that were not focused on the subject of this review.

RESULTS

Meta-analysis by year was performed on 21 studies containing 75 total mean THC observations from 1979 to 2009 using the random effects model. The results revealed much variability between studies. Further, there was a significant correlation between year and mean THC in herbal cannabis. The combined data indicated the correlation between year and mean THC in herbal cannabis, revealing a temporal trend of increasing potency (5% above the mean THC value in the Poisson regression analysis).

CONCLUSIONS

The results of the analysis suggest that there has been a recent and consistent increase in cannabis potency worldwide.

Authors+Show Affiliations

Istituto di Medicina Legale, Università Cattolica del S Cuore, largo F. Vito, 1 00168 Roma, Italy. f.cascini@rm.unicatt.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

22150622

Citation

Cascini, Fidelia, et al. "Increasing Delta-9-tetrahydrocannabinol (Δ-9-THC) Content in Herbal Cannabis Over Time: Systematic Review and Meta-analysis." Current Drug Abuse Reviews, vol. 5, no. 1, 2012, pp. 32-40.
Cascini F, Aiello C, Di Tanna G. Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis. Curr Drug Abuse Rev. 2012;5(1):32-40.
Cascini, F., Aiello, C., & Di Tanna, G. (2012). Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis. Current Drug Abuse Reviews, 5(1), 32-40.
Cascini F, Aiello C, Di Tanna G. Increasing Delta-9-tetrahydrocannabinol (Δ-9-THC) Content in Herbal Cannabis Over Time: Systematic Review and Meta-analysis. Curr Drug Abuse Rev. 2012;5(1):32-40. PubMed PMID: 22150622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis. AU - Cascini,Fidelia, AU - Aiello,Carola, AU - Di Tanna,Gianluca, PY - 2011/09/01/received PY - 2011/10/27/revised PY - 2011/10/28/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/7/19/medline SP - 32 EP - 40 JF - Current drug abuse reviews JO - Curr Drug Abuse Rev VL - 5 IS - 1 N2 - AIM: The objective of this meta-analysis is to assess the data regarding changes in herbal cannabis potency over time (from 1970 to 2009). METHODS: Systematic searches of 17 electronic scientific databases identified studies on this topic, within which 21 case series studies satisfied our inclusion criteria of reporting the mean tetrahydrocannabinol (THC) value per number of samples per year. No language, publication date, publication type or status restrictions were imposed. The study selection and data extraction processes were performed independently but uniformly by two authors, included screening, determination of eligibility and inclusion of the eligible studies in the systematic review, and a meta-analysis of the results on THC content in herbal cannabis samples. We considered papers and not monographic scientific publications, rejecting all studies that were not focused on the subject of this review. RESULTS: Meta-analysis by year was performed on 21 studies containing 75 total mean THC observations from 1979 to 2009 using the random effects model. The results revealed much variability between studies. Further, there was a significant correlation between year and mean THC in herbal cannabis. The combined data indicated the correlation between year and mean THC in herbal cannabis, revealing a temporal trend of increasing potency (5% above the mean THC value in the Poisson regression analysis). CONCLUSIONS: The results of the analysis suggest that there has been a recent and consistent increase in cannabis potency worldwide. SN - 1874-4745 UR - https://www.unboundmedicine.com/medline/citation/22150622/Increasing_delta_9_tetrahydrocannabinol__Δ_9_THC__content_in_herbal_cannabis_over_time:_systematic_review_and_meta_analysis_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1874-4737&volume=5&issue=1&spage=32&aulast=Cascini DB - PRIME DP - Unbound Medicine ER -