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Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease.
J Vet Intern Med. 2012 Jan-Feb; 26(1):61-8.JV

Abstract

BACKGROUND

Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction.

HYPOTHESIS

That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction.

ANIMALS

Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity.

METHODS

Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses.

RESULTS

Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R(2) = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R(2) = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers.

CONCLUSIONS AND CLINICAL IMPORTANCE

Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target.

Authors+Show Affiliations

Department of Basic Animal and Veterinary Sciences, University of Copenhagen, Frederiksberg, Denmark. som@life.ku.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22151409

Citation

Moesgaard, S G., et al. "Flow-mediated Vasodilation Measurements in Cavalier King Charles Spaniels With Increasing Severity of Myxomatous Mitral Valve Disease." Journal of Veterinary Internal Medicine, vol. 26, no. 1, 2012, pp. 61-8.
Moesgaard SG, Klostergaard C, Zois NE, et al. Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease. J Vet Intern Med. 2012;26(1):61-8.
Moesgaard, S. G., Klostergaard, C., Zois, N. E., Teerlink, T., Molin, M., Falk, T., Rasmussen, C. E., Luis Fuentes, V., Jones, I. D., & Olsen, L. H. (2012). Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease. Journal of Veterinary Internal Medicine, 26(1), 61-8. https://doi.org/10.1111/j.1939-1676.2011.00846.x
Moesgaard SG, et al. Flow-mediated Vasodilation Measurements in Cavalier King Charles Spaniels With Increasing Severity of Myxomatous Mitral Valve Disease. J Vet Intern Med. 2012 Jan-Feb;26(1):61-8. PubMed PMID: 22151409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease. AU - Moesgaard,S G, AU - Klostergaard,C, AU - Zois,N E, AU - Teerlink,T, AU - Molin,M, AU - Falk,T, AU - Rasmussen,C E, AU - Luis Fuentes,V, AU - Jones,I D, AU - Olsen,L H, Y1 - 2011/12/13/ PY - 2011/02/11/received PY - 2011/09/26/revised PY - 2011/10/28/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/5/18/medline SP - 61 EP - 8 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 26 IS - 1 N2 - BACKGROUND: Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction. HYPOTHESIS: That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction. ANIMALS: Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity. METHODS: Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses. RESULTS: Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R(2) = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R(2) = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers. CONCLUSIONS AND CLINICAL IMPORTANCE: Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/22151409/Flow_mediated_vasodilation_measurements_in_Cavalier_King_Charles_Spaniels_with_increasing_severity_of_myxomatous_mitral_valve_disease_ L2 - https://doi.org/10.1111/j.1939-1676.2011.00846.x DB - PRIME DP - Unbound Medicine ER -