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Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects.
J Cosmet Dermatol. 2011 Dec; 10(4):273-81.JC

Abstract

BACKGROUND

The dermal extracellular matrix provides stability and structure to the skin. With increasing age, however, its major component collagen is subject to degeneration, resulting in a gradual decline in skin elasticity and progression of wrinkle formation. Previous studies suggest that the reduction in cellular energy contributes to the diminished synthesis of cutaneous collagen during aging.

AIMS

To investigate the potential of topically applied creatine to improve the clinical signs of skin aging by stimulating dermal collagen synthesis in vitro and in vivo.

PATIENTS/METHODS

Penetration experiments were performed with a pig skin ex vivo model. Effects of creatine on dermal collagen gene expression and procollagen synthesis were studied in vitro using cultured fibroblast-populated collagen gels. In a single-center, controlled study, 43 male Caucasians applied a face-care formulation containing creatine, guarana extract, and glycerol to determine its influence on facial topometric features.

RESULTS

Cultured human dermal fibroblasts supplemented with creatine displayed a stimulation of collagen synthesis relative to untreated control cells both on the gene expression and at the protein level. In skin penetration experiments, topically applied creatine rapidly reached the dermis. In addition, topical in vivo application of a creatine-containing formulation for 6 weeks significantly reduced the sagging cheek intensity in the jowl area as compared to baseline. This result was confirmed by clinical live scoring, which also demonstrated a significant reduction in crow's feet wrinkles and wrinkles under the eyes.

CONCLUSIONS

In summary, creatine represents a beneficial active ingredient for topical use in the prevention and treatment of human skin aging.

Authors+Show Affiliations

Department of Skin Biology and Skin Structure, Beiersdorf AG Research and Development, Unnastrasse 48, Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

22151935

Citation

Peirano, Reto I., et al. "Dermal Penetration of Creatine From a Face-care Formulation Containing Creatine, Guarana and Glycerol Is Linked to Effective Antiwrinkle and Antisagging Efficacy in Male Subjects." Journal of Cosmetic Dermatology, vol. 10, no. 4, 2011, pp. 273-81.
Peirano RI, Achterberg V, Düsing HJ, et al. Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects. J Cosmet Dermatol. 2011;10(4):273-81.
Peirano, R. I., Achterberg, V., Düsing, H. J., Akhiani, M., Koop, U., Jaspers, S., Krüger, A., Schwengler, H., Hamann, T., Wenck, H., Stäb, F., Gallinat, S., & Blatt, T. (2011). Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects. Journal of Cosmetic Dermatology, 10(4), 273-81. https://doi.org/10.1111/j.1473-2165.2011.00579.x
Peirano RI, et al. Dermal Penetration of Creatine From a Face-care Formulation Containing Creatine, Guarana and Glycerol Is Linked to Effective Antiwrinkle and Antisagging Efficacy in Male Subjects. J Cosmet Dermatol. 2011;10(4):273-81. PubMed PMID: 22151935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects. AU - Peirano,Reto I, AU - Achterberg,Volker, AU - Düsing,Hans-Jürgen, AU - Akhiani,Mehdi, AU - Koop,Urte, AU - Jaspers,Sören, AU - Krüger,Andrea, AU - Schwengler,Helge, AU - Hamann,Tina, AU - Wenck,Horst, AU - Stäb,Franz, AU - Gallinat,Stefan, AU - Blatt,Thomas, PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/4/26/medline SP - 273 EP - 81 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 10 IS - 4 N2 - BACKGROUND: The dermal extracellular matrix provides stability and structure to the skin. With increasing age, however, its major component collagen is subject to degeneration, resulting in a gradual decline in skin elasticity and progression of wrinkle formation. Previous studies suggest that the reduction in cellular energy contributes to the diminished synthesis of cutaneous collagen during aging. AIMS: To investigate the potential of topically applied creatine to improve the clinical signs of skin aging by stimulating dermal collagen synthesis in vitro and in vivo. PATIENTS/METHODS: Penetration experiments were performed with a pig skin ex vivo model. Effects of creatine on dermal collagen gene expression and procollagen synthesis were studied in vitro using cultured fibroblast-populated collagen gels. In a single-center, controlled study, 43 male Caucasians applied a face-care formulation containing creatine, guarana extract, and glycerol to determine its influence on facial topometric features. RESULTS: Cultured human dermal fibroblasts supplemented with creatine displayed a stimulation of collagen synthesis relative to untreated control cells both on the gene expression and at the protein level. In skin penetration experiments, topically applied creatine rapidly reached the dermis. In addition, topical in vivo application of a creatine-containing formulation for 6 weeks significantly reduced the sagging cheek intensity in the jowl area as compared to baseline. This result was confirmed by clinical live scoring, which also demonstrated a significant reduction in crow's feet wrinkles and wrinkles under the eyes. CONCLUSIONS: In summary, creatine represents a beneficial active ingredient for topical use in the prevention and treatment of human skin aging. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/22151935/Dermal_penetration_of_creatine_from_a_face_care_formulation_containing_creatine_guarana_and_glycerol_is_linked_to_effective_antiwrinkle_and_antisagging_efficacy_in_male_subjects_ L2 - https://doi.org/10.1111/j.1473-2165.2011.00579.x DB - PRIME DP - Unbound Medicine ER -