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The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis.
J Helminthol. 2013 Mar; 87(1):1-11.JH

Abstract

Angiostrongylus cantonensis (A. cantonensis) infection causes eosinophilic meningitis in humans. Eosinophilia and a Th2-type immune response are the crucial immune mechanisms for eosinophilic meningitis. CD4+CD25+ regulatory T cells (Treg) are involved in the pathogenesis of A. cantonensis. Diammonium glycyrrhizinate (DG) is a compound related to glycyrrhizin (GL), a triterpene glycoside extracted from liquorice root. We investigated the curative effects and probable mechanisms of therapy involving a combination of albendazole and DG in BALB/c mice infected with A. cantonensis, and compared these with therapy involving albendazole and dexamethasone. We analysed survival time, body weight, signs, eosinophil numbers, immunoglobulin E (IgE), interleukin-5 (IL-5), and eotaxin concentrations, numbers and Foxp3 expression of CD4+CD25+ Treg, worm recovery and histopathology. The present results demonstrated that the combination of albendazole and DG could increase survival time more efficiently and relieve neurological dysfunction; decrease weight loss, eosinophil numbers, concentrations of IgE, IL-5 and eotaxin, the number and expression of Foxp3 of CD4+CD25+ Treg; and improve worm recovery and histopathology changes in treated animals, compared with the combination of albendazole and dexamethasone. The observations presented here suggest that the albendazole and dexamethasone combination could be replaced by the combination of albendazole and DG.

Authors+Show Affiliations

Department of Biopharmaceuticals, School of Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22152396

Citation

Li, Y, et al. "The Use of Albendazole and Diammonium Glycyrrhizinate in the Treatment of Eosinophilic Meningitis in Mice Infected With Angiostrongylus Cantonensis." Journal of Helminthology, vol. 87, no. 1, 2013, pp. 1-11.
Li Y, Tang JP, Chen DR, et al. The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis. J Helminthol. 2013;87(1):1-11.
Li, Y., Tang, J. P., Chen, D. R., Fu, C. Y., Wang, P., Li, Z., Wei, W., Li, H., & Dong, W. Q. (2013). The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis. Journal of Helminthology, 87(1), 1-11. https://doi.org/10.1017/S0022149X11000745
Li Y, et al. The Use of Albendazole and Diammonium Glycyrrhizinate in the Treatment of Eosinophilic Meningitis in Mice Infected With Angiostrongylus Cantonensis. J Helminthol. 2013;87(1):1-11. PubMed PMID: 22152396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis. AU - Li,Y, AU - Tang,J-P, AU - Chen,D-R, AU - Fu,C-Y, AU - Wang,P, AU - Li,Z, AU - Wei,W, AU - Li,H, AU - Dong,W-Q, Y1 - 2011/12/13/ PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2013/7/19/medline SP - 1 EP - 11 JF - Journal of helminthology JO - J Helminthol VL - 87 IS - 1 N2 - Angiostrongylus cantonensis (A. cantonensis) infection causes eosinophilic meningitis in humans. Eosinophilia and a Th2-type immune response are the crucial immune mechanisms for eosinophilic meningitis. CD4+CD25+ regulatory T cells (Treg) are involved in the pathogenesis of A. cantonensis. Diammonium glycyrrhizinate (DG) is a compound related to glycyrrhizin (GL), a triterpene glycoside extracted from liquorice root. We investigated the curative effects and probable mechanisms of therapy involving a combination of albendazole and DG in BALB/c mice infected with A. cantonensis, and compared these with therapy involving albendazole and dexamethasone. We analysed survival time, body weight, signs, eosinophil numbers, immunoglobulin E (IgE), interleukin-5 (IL-5), and eotaxin concentrations, numbers and Foxp3 expression of CD4+CD25+ Treg, worm recovery and histopathology. The present results demonstrated that the combination of albendazole and DG could increase survival time more efficiently and relieve neurological dysfunction; decrease weight loss, eosinophil numbers, concentrations of IgE, IL-5 and eotaxin, the number and expression of Foxp3 of CD4+CD25+ Treg; and improve worm recovery and histopathology changes in treated animals, compared with the combination of albendazole and dexamethasone. The observations presented here suggest that the albendazole and dexamethasone combination could be replaced by the combination of albendazole and DG. SN - 1475-2697 UR - https://www.unboundmedicine.com/medline/citation/22152396/The_use_of_albendazole_and_diammonium_glycyrrhizinate_in_the_treatment_of_eosinophilic_meningitis_in_mice_infected_with_Angiostrongylus_cantonensis_ L2 - https://www.cambridge.org/core/product/identifier/S0022149X11000745/type/journal_article DB - PRIME DP - Unbound Medicine ER -